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Original Articles

Detection of Sildenafil Analogues in Herbal Products for Erectile Dysfunction

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Pages 1951-1958 | Accepted 28 Nov 2005, Published online: 05 Dec 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Charlie Li, Dadong Xu & Bahman Moezzi. (2021) Identification of Erectile Dysfunction Drugs in Dietary Supplements by Liquid Chromatography Ion Trap Mass Spectrometry. Journal of Dietary Supplements 18:3, pages 261-277.
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Jiebiao Guo, Wangpei Liu, Xianquan Lan, Hualong Chen & Zijun Xiao. (2016) Development and evaluation of an immunochromatographic strip for rapid screening of sildenafil-type compounds as illegal additives in functional foods. Food Additives & Contaminants: Part A 33:7, pages 1095-1104.
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N.M. Reeuwijk, B.J. Venhuis, D. de Kaste, L.A.P. Hoogenboom, I.M.C.M. Rietjens & M.J. Martena. (2013) Sildenafil and analogous phosphodiesterase type 5 (PDE-5) inhibitors in herbal food supplements sampled on the Dutch market. Food Additives & Contaminants: Part A 30:12, pages 2027-2034.
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Yu Cai, Tian-Ge Cai, Yan Shi, Xian-Long Cheng, Ling-Yun Ma, Shuang-Cheng Ma, Rui-Chao Lin & Wei Feng. (2010) SIMULTANEOUS DETERMINATION OF EIGHT PDE5-IS POTENTIALLY ADULTERATED IN HERBAL DIETARY SUPPLEMENTS WITH TLC AND HPLC-PDA-MS METHODS. Journal of Liquid Chromatography & Related Technologies 33:13, pages 1287-1306.
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Articles from other publishers (28)

Daniel Moser, Shah Hussain, Muhammad Yaqoob, Matthias Rainer, Thomas Jakschitz & Günther K. Bonn. (2022) Fast and semiquantitative screening for sildenafil in herbal over-the-counter formulations with atmospheric pressure solid analysis probe (ASAP) to prevent medicinal adulteration. Journal of Pharmaceutical and Biomedical Analysis 214, pages 114720.
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Kanchanok Kodchakorn, Nawarat Viriyakhasem, Tunchanok Wongwichai & Prachya Kongtawelert. (2021) Structural Determination, Biological Function, and Molecular Modelling Studies of Sulfoaildenafil Adulterated in Herbal Dietary Supplement. Molecules 26:4, pages 949.
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Liliana Muschietti, Flavia Redko & Jerónimo Ulloa. (2020) Adulterants in selected dietary supplements and their detection methods. Drug Testing and Analysis 12:7, pages 861-886.
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Unyong Kim, Hyun-Deok Cho, Myung Hee Kang, Joon Hyuk Suh, Han Young Eom, Junghyun Kim, Sumin Seo, Gunwoo Kim, Hye Ryoung Koo, Nary Ha, Un Tak Song & Sang Beom Han. (2020) Screening of Phosphodiesterase-5 Inhibitors and Their Analogs in Dietary Supplements by Liquid Chromatography–Hybrid Ion Trap–Time of Flight Mass Spectrometry. Molecules 25:12, pages 2734.
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Zhongxing Wang, Xiaoling Wu, Liqiang Liu, Liguang Xu, Hua Kuang & Chuanlai Xu. (2019) An immunochromatographic strip sensor for sildenafil and its analogues. Journal of Materials Chemistry B 7:41, pages 6383-6389.
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S. Wilczyńki, M. Petelenz, M. Florek-Wojciechowska, S. Kulesza, Sz. Brym, B. Błońska-Fajfrowska & D. Kruk. (2017) Verification of the authenticity of drugs by means of NMR relaxometry—Viagra ® as an example. Journal of Pharmaceutical and Biomedical Analysis 135, pages 199-205.
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S.S. Agrawal & Garima Mishra. (2016) Adulteration of synthetic PDE-5 inhibitors viz., sildenafil and tadalafil in marketed herbal aphrodisiacs. Current Medicine Research and Practice 6:4, pages 152-156.
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Jeronimo Ulloa, Luis Sambrotta, Flavia Redko, Osvaldo Nestor Mazza, Gustavo Garrido, Edgardo F. Becher & Liliana Muschietti. (2015) Detection of a Tadalafil Analogue as an Adulterant in a Dietary Supplement for Erectile Dysfunction. The Journal of Sexual Medicine 12:1, pages 152-157.
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Richard A. Lange & Glenn N. Levine. (2014) Sexual Activity and Ischemic Heart Disease. Current Cardiology Reports 16:2.
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Jamshed Haneef, Mohammad Shaharyar, Asif Husain, Mohd Rashid, Ravinesh Mishra, Nadeem A. Siddique & Manoj Pal. (2013) Analytical methods for the detection of undeclared synthetic drugs in traditional herbal medicines as adulterants. Drug Testing and Analysis 5:8, pages 607-613.
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Wendy L. Applequist & James S. Miller. (2012) Selection and authentication of botanical materials for the development of analytical methods. Analytical and Bioanalytical Chemistry 405:13, pages 4419-4428.
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Daniel J. Mans, Rebecca J. Callahan, Jamie D. Dunn & Connie M. Gryniewicz-Ruzicka. (2013) Rapid-screening detection of acetildenafils, sildenafils and avanafil by ion mobility spectrometry. Journal of Pharmaceutical and Biomedical Analysis 75, pages 153-157.
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Chee-Leong Kee, Xiaowei Ge, Hwee-Ling Koh & Min-Yong Low. (2012) Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements. Journal of Pharmaceutical and Biomedical Analysis 70, pages 265-272.
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B.J. Venhuis & D. de Kaste. (2012) Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: A history, analytical aspects and health risks. Journal of Pharmaceutical and Biomedical Analysis 69, pages 196-208.
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Glenn N. Levine, Elaine E. Steinke, Faisal G. Bakaeen, Biykem Bozkurt, Melvin D. Cheitlin, Jamie Beth Conti, Elyse Foster, Tiny Jaarsma, Robert A. Kloner, Richard A. Lange, Stacy Tessler Lindau, Barry J. Maron, Debra K. Moser, E. Magnus Ohman, Allen D. Seftel & William J. Stewart. (2012) Sexual Activity and Cardiovascular Disease. Circulation 125:8, pages 1058-1072.
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Uttam Garg & Angela M. Ferguson. 2010. Herbal Supplements. Herbal Supplements 369 386 .
Andrea Lugasi, Márta Horacsek & Éva Martos. (2010) Food supplements on the domestic market in Hungary. Nutritional assessment of the ingredients, risks and benefits, the role of food supplements in human nutrition. Orvosi Hetilap 151:48, pages 1964-1975.
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Dezső Csupor, András Szekeres, Anita Kecskeméti, Erika Vékes, Katalin Veres, Ákos Micsinay, Kálmán Szendrei & Judit Hohmann. (2010) Dietary supplements on the domestic market adulterated with sildenafil and tadalafil. Orvosi Hetilap 151:43, pages 1783-1789.
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Adrian Häberli, Philippe Girard, Min-Yong Low & Xiaowei Ge. (2010) Isolation and structure elucidation of an interaction product of aminotadalafil found in an illegal health food product. Journal of Pharmaceutical and Biomedical Analysis 53:1, pages 24-28.
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Akash A. Savaliya, Ravi P. Shah, Bhagwat Prasad & Saranjit Singh. (2010) Screening of Indian aphrodisiac ayurvedic/herbal healthcare products for adulteration with sildenafil, tadalafil and/or vardenafil using LC/PDA and extracted ion LC–MS/TOF. Journal of Pharmaceutical and Biomedical Analysis 52:3, pages 406-409.
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Min-Yong Low, Yun Zeng, Lin Li, Xiao-Wei Ge, Ruth Lee, Bosco-Chen Bloodworth & Hwee-Ling Koh. (2009) Safety and Quality Assessment of 175 Illegal Sexual Enhancement Products Seized in Red-Light Districts in Singapore. Drug Safety 32:12, pages 1141-1146.
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Saleh Trefi, Véronique Gilard, Stéphane Balayssac, Myriam Malet-Martino & Robert Martino. (2009) The usefulness of 2D DOSY and 3D DOSY-COSY 1 H NMR for mixture analysis: application to genuine and fake formulations of sildenafil (Viagra) . Magnetic Resonance in Chemistry 47:S1, pages S163-S173.
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Connie M. Gryniewicz, John C. Reepmeyer, John F. Kauffman & Lucinda F. Buhse. (2009) Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry. Journal of Pharmaceutical and Biomedical Analysis 49:3, pages 601-606.
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John C. Reepmeyer & D. André d’Avignon. (2009) Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs. Journal of Pharmaceutical and Biomedical Analysis 49:1, pages 145-150.
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J.C. Griffiths, D.R. Abernethy, S. Schuber & R.L. Williams. (2009) Functional food ingredient quality: Opportunities to improve public health by compendial standardization. Journal of Functional Foods 1:1, pages 128-130.
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Peng Zou, Peiling Hou, Sharon Sze-Yin Oh, Y.M. Chong, Bosco Chen Bloodworth, Min-Yong Low & Hwee-Ling Koh. (2008) Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements. Journal of Pharmaceutical and Biomedical Analysis 47:2, pages 279-284.
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John C. Reepmeyer & Jeffrey T. Woodruff. (2007) Use of liquid chromatography–mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement. Journal of Pharmaceutical and Biomedical Analysis 44:4, pages 887-893.
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Peng Zou, Sharon Sze-Yin Oh, Kin-Har Kiang, Min-Yong Low & Hwee-Ling Koh. (2017) Letter: Liquid Chromatography Ion-Trap Time-of-Flight Mass Spectrometric Study on the Fragmentation of an Acetildenafil Analogue. European Journal of Mass Spectrometry 13:3, pages 233-238.
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