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Original Articles

Rhapontigenin from Rheum undulatum Protects Against Oxidative-Stress-Induced Cell Damage Through Antioxidant Activity

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Pages 1155-1166 | Received 19 Jun 2006, Accepted 30 Aug 2006, Published online: 07 Jun 2007

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Articles from other publishers (32)

Ying-Xiao Wang, Xin-Ge Ke, Chen Wang, Kang-Bo Peng, He-Zhen Wu & Yan-Fang Yang. (2023) Rhapontigenin Improves Non-alcoholic Fatty Liver Disease by Inducing Lipophagy Through the ACOX1 and mTOR/ULK1 Pathways. Pharmacognosy Magazine.
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Oleksandra Liudvytska, Magdalena Bandyszewska, Tomasz Skirecki, Justyna Krzyżanowska-Kowalczyk, Mariusz Kowalczyk & Joanna Kolodziejczyk-Czepas. (2023) Anti-inflammatory and antioxidant actions of extracts from Rheum rhaponticum and Rheum rhabarbarum in human blood plasma and cells in vitro. Biomedicine & Pharmacotherapy 165, pages 115111.
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Silvia Navarro-Orcajada, Francisco José Vidal-Sánchez, Irene Conesa, Adrián Matencio & José Manuel López-Nicolás. (2023) Improvement of the Physicochemical Limitations of Rhapontigenin, a Cytotoxic Analogue of Resveratrol against Colon Cancer. Biomolecules 13:8, pages 1270.
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Roghayeh Rashidi, Amir Reza Afshari, Hamid Mollazadeh & Azar Hosseini. (2022) Rheum turkestanicum Janisch Root Extract Mitigates 6-OHDA-Induced Neuronal Toxicity Against Human Neuroblastoma SH-SY5Y Cells. Journal of Advances in Medical and Biomedical Research 30:143, pages 553-560.
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Claude Grison, Lucie Cases, Mailys Le Moigne & Martine Hossaert‐McKey. 2022. Photovoltaism, Agriculture and Ecology. Photovoltaism, Agriculture and Ecology 121 134 .
Jingzhi An, Jie Yang, Yuan Wei, Yunsi Liu, Yan Song, Zuzhuo Zhang & Ying Pan. (2021) Identification of the metabolites of rhapontigenin in rat and human by ultra‐high‐performance liquid chromatography—high‐resolution mass spectrometry. Rapid Communications in Mass Spectrometry 35:20.
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Tiansong Yang, Qingyong Wang, Yuanyuan Qu, Chuwen Feng, Chaoran Li, Yan Yang, Zhongren Sun, Tahani A. Alahmadi, Sulaiman A. Alharbi & Shengyong Bao. (2021) Protective effect of rhaponticin on ovariectomy‐induced osteoporosis in rats. Journal of Biochemical and Molecular Toxicology 35:9.
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Suresh Mickymaray, Faiz Abdulaziz Alfaiz, Anand Paramasivam, Vishnu Priya Veeraraghavan, Nanthini Devi Periadurai, Krishna Mohan Surapaneni & Guangfeng Niu. (2021) Rhaponticin suppresses osteosarcoma through the inhibition of PI3K-Akt-mTOR pathway. Saudi Journal of Biological Sciences 28:7, pages 3641-3649.
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Joanna Kolodziejczyk-Czepas & Oleksandra Liudvytska. (2020) Rheum rhaponticum and Rheum rhabarbarum: a review of phytochemistry, biological activities and therapeutic potential. Phytochemistry Reviews 20:3, pages 589-607.
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Rougang Li, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H. M. Shair, Vishnu Priya Veeraraghavan, Krishna Mohan Surapaneni & Thamaraiselvan Rengarajan. (2021) Anti‐inflammatory effects of rhaponticin on LPS‐induced human endothelial cells through inhibition of MAPK/NF‐κβ signaling pathways. Journal of Biochemical and Molecular Toxicology 35:5.
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Fangfang Zhao, Huijun Tian, Arunachalam Chinnathambi, Sulaiman Ali Alharbi & Hongan Yang. (2020) Neuroprotective effect of rhaponticin against Parkinson disease: Insights from in vitro BV‐2 model and in vivo MPTP‐induced mice model. Journal of Biochemical and Molecular Toxicology 35:1.
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Qiang Shi, Yuhong Cheng, Xiaomin Dong, Ming Zhang, Cheng Pei & Mingzhen Zhang. (2020) Effects of rhaponticin on retinal oxidative stress and inflammation in diabetes through NRF2/HO‐1/NF‐κB signalling. Journal of Biochemical and Molecular Toxicology 34:11.
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Dan Chen, Jing-Ru Liu, Yanjin Cheng, Hua Cheng, Ping He & Yang Sun. (2020) Metabolism of Rhaponticin and Activities of its Metabolite, Rhapontigenin: A Review. Current Medicinal Chemistry 27:19, pages 3168-3186.
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Su Youn Baek, Eun Hye Lee, Tae Woo Oh, Hyun Ju Do, Kwang-Youn Kim, Kwang-Il Park & Young Woo Kim. (2020) Network Pharmacology-Based Approaches of Rheum undulatum Linne and Glycyrriza uralensis Fischer Imply Their Regulation of Liver Failure with Hepatic Encephalopathy in Mice. Biomolecules 10:3, pages 437.
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Jin-Jie Zhang, Xiao-Rong Shi, Wen-Wen Lv, Xiao-Long Zhou, Ying-Dong Sun, Bao-Yuan Li & Xiao-Long Hu. (2020) Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL/6 Mice. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-10.
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Joanna Kolodziejczyk-Czepas & Jan Czepas. (2019) Rhaponticin as an anti-inflammatory component of rhubarb: a minireview of the current state of the art and prospects for future research. Phytochemistry Reviews 18:5, pages 1375-1386.
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Deok-Sang Hwang, Pil Sung Gu, Namkwon Kim, Young Pyo Jang & Myung Sook Oh. (2018) Effects of Rhei Undulati Rhizoma on lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Environmental Toxicology 33:1, pages 23-31.
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Bing Wan, Hao Zhang, Jiangtao Yin, Haiyan Fu, Yikun Chen, Liping Yang, Dadong Liu, Tangfeng Lv & Yong Song. (2017) Rhubarb vs. glycerin enema for treatment of critically ill patients with intra-abdominal hypertension. Experimental and Therapeutic Medicine 14:1, pages 855-861.
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Nimisha Vijayan, Madathilkovilakath Haridas & Sabu Abdulhameed. 2017. Bioresources and Bioprocess in Biotechnology. Bioresources and Bioprocess in Biotechnology 407 418 .
Yi Yong, Ammar Saleem, José A. Guerrero-Analco, Pierre S. Haddad, Alain Cuerrier, John T. Arnason, Cory S. Harris & Tim Johns. (2016) Larix laricina bark, a traditional medicine used by the Cree of Eeyou Istchee: Antioxidant constituents and in vitro permeability across Caco-2 cell monolayers. Journal of Ethnopharmacology 194, pages 651-657.
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Eun Hye Lee, Su Youn Baek, Kwang-Youn Kim, Seul-Gi Lee, Sang Chan Kim, Hyeong Sik Lee & Young Woo Kim. (2016) Effect of Rheum undulatum Linne extract and Glycyrriza uralensis Fischer extract against arachidonic acid and iron-induced oxidative stress in HepG2 cell and CCl 4 -induced liver injury in mice . Herbal Formula Science 24:3, pages 163-174.
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Azar Hosseini & Arezoo Rajabian. (2016) Protective effect of Rheum turkestanikum root against doxorubicin-induced toxicity in H9c2 cells. Revista Brasileira de Farmacognosia 26:3, pages 347-351.
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Ji Sung Kim, Chi Gu Kang, Sung-Hoon Kim & Eun-Ok Lee. (2014) Rhapontigenin Suppresses Cell Migration and Invasion by Inhibiting the PI3K-Dependent Rac1 Signaling Pathway in MDA-MB-231 Human Breast Cancer Cells. Journal of Natural Products 77:5, pages 1135-1139.
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A. Poudel, S.-G. Kim, R. Lamichhane, Y.-K. Kim, H.-K. Jo & H.-J. Jung. (2013) Quantitative Assessment of Traditional Oriental Herbal Formulation Samhwangsasim-tang Using UPLC Technique. Journal of Chromatographic Science 52:2, pages 176-185.
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Xu Hua Liang, Yang Sun, Lu Sha Liu, Ying Yong Zhao, Xiao Yun Hu & Jun Fan. (2012) Regioselective synthesis and initial evaluation of a folate receptor targeted rhaponticin prodrug. Chinese Chemical Letters 23:10, pages 1133-1136.
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Ying-Yong ZhaoQi Su, Xian-Long Cheng, Xiao-Jie Tan, Xu Bai & Rui-Chao Lin. (2012) Pharmacokinetics, bioavailability and metabolism of rhaponticin in rat plasma by UHPLC–Q-TOF/MS and UHPLC–DAD–MS n . Bioanalysis 4:6, pages 713-723.
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Cyrille Marvalin & Robert Azerad. (2011) Microbial glucuronidation of polyphenols. Journal of Molecular Catalysis B: Enzymatic 73:1-4, pages 43-52.
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Keun-Tae Park, Jeong-Keun Kim, Dahyun Hwang, Yeongmin Yoo & Young-Hee Lim. (2011) Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation. Food and Chemical Toxicology 49:12, pages 3038-3045.
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Yingyong Zhao, Lili Wang, Hua Miao, Charlene C. Ho, Jing Li, Xianlong Cheng, Yongmin Zhang, Ruichao Lin & Wenji Sun. (2011) LC Method for the Determination of Rhaponticin in Rat Plasma, Faeces and Urine for Application to Pharmacokinetic Studies. Chromatographia 73:5-6, pages 599-603.
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Deok-Beom Jung, Hyo-Jeong Lee, Soo-Jin Jeong, Hyo-Jung Lee, Eun-Ok Lee, Young Chul Kim, Kyoo Seok Ahn, Chang-Yan Chen & Sung-Hoon Kim. (2011) Rhapontigenin Inhibited Hypoxia Inducible Factor 1 Alpha Accumulation and Angiogenesis in Hypoxic PC-3 Prostate Cancer Cells. Biological and Pharmaceutical Bulletin 34:6, pages 850-855.
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Ronald N. Kostoff, Michael B. Briggs & Terence J. Lyons. (2008) Literature-related discovery (LRD): Potential treatments for Multiple Sclerosis. Technological Forecasting and Social Change 75:2, pages 239-255.
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