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Original Articles

Pharmacokinetic Modeling of Manganese. II. Hepatic Processing After Ingestion and Inhalation

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Pages 1505-1514 | Received 19 Oct 2006, Accepted 10 Jan 2007, Published online: 17 Aug 2007

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Pamela K. Douglas, Mark S. Cohen & Joseph J. DiStefano$suffix/text()$suffix/text(). (2010) Chronic exposure to Mn inhalation may have lasting effects: A physiologically-based toxicokinetic model in rats. Toxicological & Environmental Chemistry 92:2, pages 279-299.
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Melvin E. Andersen, David C. Dorman, Harvey J. Clewell$suffix/text()$suffix/text(), Michael D. Taylor & Andy Nong. (2010) Multi-Dose-Route, Multi-Species Pharmacokinetic Models for Manganese and Their Use in Risk Assessment. Journal of Toxicology and Environmental Health, Part A 73:2-3, pages 217-234.
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William K. Boyes. (2010) Essentiality, Toxicity, and Uncertainty in the Risk Assessment of Manganese. Journal of Toxicology and Environmental Health, Part A 73:2-3, pages 159-165.
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Andy Nong, JustinG. Teeguarden, HarveyJ. Clewell$suffix/text()$suffix/text(), DavidC. Dorman & MelvinE. Andersen. (2008) Pharmacokinetic Modeling of Manganese in the Rat IV: Assessing Factors that Contribute to Brain Accumulation During Inhalation Exposure. Journal of Toxicology and Environmental Health, Part A 71:7, pages 413-426.
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JustinG. Teeguarden, Jeffrey Gearhart, HarveyJ. Clewell$suffix/text()$suffix/text(), TammieR. Covington, Andy Nong & MelvinE. Andersen. (2007) Pharmacokinetic Modeling of Manganese. III. Physiological Approaches Accounting for Background and Tracer Kinetics. Journal of Toxicology and Environmental Health, Part A 70:18, pages 1515-1526.
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JustinG. Teeguarden, DavidC. Dorman, TammieR. Covington, HarveyJ. Clewell$suffix/text()$suffix/text() & MelvinE. Andersen. (2007) Pharmacokinetic Modeling of Manganese. I. Dose Dependencies of Uptake and Elimination. Journal of Toxicology and Environmental Health, Part A 70:18, pages 1493-1504.
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Articles from other publishers (17)

Camarie S. Perry, Alexander D. Blanchette, Stephanie N. Vivanco, Ann H. Verwiel & Deborah M. Proctor. (2023) Use of physiologically based pharmacokinetic modeling to support development of an acute (24-hour) health-based inhalation guideline for manganese. Regulatory Toxicology and Pharmacology 145, pages 105518.
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Jerry L Campbell, Harvey J ClewellIIIIII, Cynthia Van Landingham, P Robinan Gentry, Athena M Keene, Michael D Taylor & Melvin E Andersen. (2023) Incorporation of rapid association/dissociation processes in tissues into the monkey and human physiologically based pharmacokinetic models for manganese. Toxicological Sciences 191:2, pages 212-226.
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M. Moiz Mumtaz, Bruce A. Fowler,Patricia Ruiz. 2022. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 237 252 .
Gina Song, Cynthia B. Van Landingham, P. Robinan Gentry, Michael D. Taylor, Athena M. Keene, Melvin E. Andersen, Harvey J. Clewell & Miyoung Yoon. (2018) Physiologically-based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water. Toxicology and Applied Pharmacology 359, pages 70-81.
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Darcie Smith, George M. Woodall, Annie M. Jarabek & William K. Boyes. (2018) Manganese testing under a clean air act test rule and the application of resultant data in risk assessments. NeuroToxicology 64, pages 177-184.
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P. Robinan Gentry, Cynthia Van Landingham, William G. Fuller, Sandra I. Sulsky, Tracy B. Greene, Harvey J. ClewellIIIIII, Melvin E. Andersen, Harry A. Roels, Michael D. Taylor & Athena M. Keene. (2017) A tissue dose-based comparative exposure assessment of manganese using physiologically based pharmacokinetic modeling—The importance of homeostatic control for an essential metal. Toxicology and Applied Pharmacology 322, pages 27-40.
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Siva P. Ramoju, Donald R. Mattison, Brittany Milton, Doreen McGough, Natalia Shilnikova, Harvey J. Clewell, Miyoung Yoon, Michael D. Taylor, Daniel Krewski & Melvin E. Andersen. (2017) The application of PBPK models in estimating human brain tissue manganese concentrations. NeuroToxicology 58, pages 226-237.
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Adam G. Gow, Polly E. Frowde, Clive M. Elwood, Carolyn A. Burton, Roger M. Powell, Simon W. Tappin, Rob D. Foale, Andrew Duncan & Richard J. Mellanby. (2015) Surgical attenuation of spontaneous congenital portosystemic shunts in dogs resolves hepatic encephalopathy but not hypermanganesemia. Metabolic Brain Disease 30:5, pages 1285-1289.
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Miyoung Yoon, Michael D. Taylor, Harvey J. Clewell & Melvin E. Andersen. 2014. Manganese in Health and Disease. Manganese in Health and Disease 322 354 .
Robert M. Park, Maryse F. Bouchard, Mary Baldwin, Rosemarie Bowler & Donna Mergler. (2014) Respiratory manganese particle size, time-course and neurobehavioral outcomes in workers at a manganese alloy production plant. NeuroToxicology 45, pages 276-284.
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Luis F. Gonzalez-Cuyar, Gill Nelson, Susan R. Criswell, Pokuan Ho, Jaymes A. Lonzanida, Harvey Checkoway, Noah Seixas, Benjamin B. Gelman, Bradley A. Evanoff, Jill Murray, Jing Zhang & Brad A. Racette. (2014) Quantitative neuropathology associated with chronic manganese exposure in South African mine workers. NeuroToxicology 45, pages 260-266.
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CC Willhite, VS Bhat, GL Ball & CJ McLellan. (2012) Emergency Do Not Consume/Do Not Use concentrations for potassium permanganate in drinking water. Human & Experimental Toxicology 32:3, pages 275-298.
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Michael D. Taylor, Harvey J. Clewell, Melvin E. Andersen, Jeffry D. Schroeter, Miyoung Yoon, Athena M. Keene & David C. Dorman. (2012) Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment. Journal of Toxicology 2012, pages 1-17.
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Jeffry D. Schroeter, Andy Nong, Miyoung Yoon, Michael D. Taylor, David C. Dorman, Melvin E. Andersen & Harvey J. ClewellIIIIII. (2011) Analysis of Manganese Tracer Kinetics and Target Tissue Dosimetry in Monkeys and Humans with Multi-Route Physiologically Based Pharmacokinetic Models. Toxicological Sciences 120:2, pages 481-498.
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Andy Nong, Michael D. Taylor, Miyoung Yoon & Melvin E. Andersen. 2010. Quantitative Modeling in Toxicology. Quantitative Modeling in Toxicology 59 82 .
Lisa A. Bailey, Julie E. Goodman & Barbara D. Beck. (2009) Proposal for a revised Reference Concentration (RfC) for manganese based on recent epidemiological studies. Regulatory Toxicology and Pharmacology 55:3, pages 330-339.
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Andy Nong, Michael D. Taylor, Harvey J. ClewellIIIIII, David C. Dorman & Melvin E. Andersen. (2009) Manganese Tissue Dosimetry in Rats and Monkeys: Accounting for Dietary and Inhaled Mn with Physiologically based Pharmacokinetic Modeling. Toxicological Sciences 108:1, pages 22-34.
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