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Journal of Toxicology and Environmental Health, Part A
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Volume 70, 2007 - Issue 15-16: Current Toxicological Issues in Korea
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Original Articles

Melittin, A Major Bioactive Component of Bee Venom Toxin, Inhibits PDGF Receptor Beta-tyrosine Phosphorylation and Downstream Intracellular Signal Transduction in Rat Aortic Vascular Smooth Muscle Cells

Dong Ju Son College of Pharmacy and CBITRC, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
,
Jun Kang College of Oriental Medicine, Kyungwon University, Seongnam, Republic of Korea
,
Tack Joong Kim College of Pharmacy and CBITRC, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
,
Ho-Sueb Song College of Oriental Medicine, Kyungwon University, Seongnam, Republic of Korea
,
Ki-Joong Sung Department of Bioscience & Biotechnology, Konkuk University, Seoul, Republic of Korea
,
Do Young Yun Department of Bioscience & Biotechnology, Konkuk University, Seoul, Republic of Korea
&
Jin Tae Hong College of Pharmacy and CBITRC, Chungbuk National University, Cheongju, Chungbuk, Republic of KoreaCorrespondence[email protected]
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Pages 1350-1355 | Published online: 24 Jul 2007

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Mostafa Akbarzadeh-Khiavi, Mitra Torabi, Amir-Hossein Olfati, Leila Rahbarnia & Azam Safary. (2022) Bio-nano scale modifications of melittin for improving therapeutic efficacy. Expert Opinion on Biological Therapy 22:7, pages 895-909.
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Articles from other publishers (24)

Soumik Goswami & Jayita Pal Chowdhury. (2023) Antiviral attributes of bee venom as a possible therapeutic approach against SARS-CoV-2 infection. Future Virology.
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Anqi Wang, Yuan Zheng, Wanxin Zhu, Liuxin Yang, Yang Yang & Jinliang Peng. (2022) Melittin-Based Nano-Delivery Systems for Cancer Therapy. Biomolecules 12:1, pages 118.
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Ghada H. Mansour, Mohammed A. El-Magd, Dalia H. Mahfouz, Ismail A. Abdelhamid, Magda F. Mohamed, Nada S. Ibrahim, Abdel Hady A. Abdel Wahab & Emad M. Elzayat. (2021) Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells. Bioorganic Chemistry 116, pages 105329.
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Keneth Iceland Kasozi, Gniewko Niedbała, Mohammed Alqarni, Gerald Zirintunda, Fred Ssempijja, Simon Peter Musinguzi, Ibe Michael Usman, Kevin Matama, Helal F. Hetta, Ngala Elvis Mbiydzenyuy, Gaber El-Saber Batiha, Amany Magdy Beshbishy & Susan Christina Welburn. (2020) Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections. Frontiers in Public Health 8.
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Li Luo, Wei Wu, Da Sun, Han-Bin Dai, Yi Wang, Yuan Zhong, Jin-Xuan Wang, Ali Maruf, Deti Nurhidayah, Xiao-Juan Zhang, Ying Wang & Gui-Xue Wang. (2018) Acid-Activated Melittin for Targeted and Safe Antitumor Therapy. Bioconjugate Chemistry 29:9, pages 2936-2944.
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V. Benno Meyer-Rochow. (2017) Therapeutic arthropods and other, largely terrestrial, folk-medicinally important invertebrates: a comparative survey and review. Journal of Ethnobiology and Ethnomedicine 13:1.
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Maira Huerta-Rey, Caroline Anselme, Anas Cherqui & Guillaume Decocq. (2017) Exploration Through the Venoms from Hymenoptera as Potential Therapeutic Agents in Cancer Therapy. International Journal of Pharmacology 13:6, pages 507-515.
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Laura Cornara, Marco Biagi, Jianbo Xiao & Bruno Burlando. (2017) Therapeutic Properties of Bioactive Compounds from Different Honeybee Products. Frontiers in Pharmacology 8.
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Kadir Erol, Kazım Köse, Hakan Güngüneş & Dursun Ali Köse. (2017) Use of amino acid-based polymeric material for isolation of a protein from poison. Journal of Molecular Structure 1130, pages 753-759.
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Madhu B. Anand-Srivastava. 2017. Mechanisms of Vascular Defects in Diabetes Mellitus. Mechanisms of Vascular Defects in Diabetes Mellitus 305 324 .
Gihyun Lee & Hyunsu Bae. (2016) Anti-Inflammatory Applications of Melittin, a Major Component of Bee Venom: Detailed Mechanism of Action and Adverse Effects. Molecules 21:5, pages 616.
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Chao-Huei Yang, Chiung-Fang Tsao, Wang-Sheng Ko & Ya-Ling Chiou. (2016) The Oligo Fucoidan Inhibits Platelet-Derived Growth Factor-Stimulated Proliferation of Airway Smooth Muscle Cells. Marine Drugs 14:1, pages 15.
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Gui-Mei Kong, Wen-Hua Tao, Ya-Li Diao, Peng-Hua Fang, Ji-Jun Wang, Ping Bo & Feng Qian. (2016) Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway . World Journal of Gastroenterology 22:11, pages 3186.
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Chiara Ricci & Nicola Ferri. (2015) Naturally occurring PDGF receptor inhibitors with potential anti-atherosclerotic properties. Vascular Pharmacology 70, pages 1-7.
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Miguel Moreno & Ernest Giralt. (2015) Three Valuable Peptides from Bee and Wasp Venoms for Therapeutic and Biotechnological Use: Melittin, Apamin and Mastoparan. Toxins 7:4, pages 1126-1150.
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Ji-Hyun Park, Woo-Ram Lee, Hyun-Soo Kim, Sang-Mi Han, Young-Chae Chang & Kwan-Kyu Park. (2014) Protective effects of melittin on tumor necrosis factor-α induced hepatic damage through suppression of apoptotic pathway and nuclear factor-kappa B activation. Experimental Biology and Medicine 239:12, pages 1705-1714.
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Yohan Kim, Joo-Hui Han, Eunju Yun, Sang-Hyuk Jung, Jung-Jin Lee, Gyu-Yong Song & Chang-Seon Myung. (2014) Inhibitory effect of a novel naphthoquinone derivative on proliferation of vascular smooth muscle cells through suppression of platelet-derived growth factor receptor β tyrosine kinase. European Journal of Pharmacology 733, pages 81-89.
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Elisabetta Bigagli, Cristina Luceri, Simonetta Bernardini, Andrea Dei, Angelica Filippini & Piero Dolara. (2014) Exploring the effects of homeopathic Apis mellifica preparations on human gene expression profiles. Homeopathy 103:2, pages 127-132.
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Yun-Jeong Jeong, Hyun-Ji Cho, Key Whang, In-Seon Lee, Kwan-Kyu Park, Jung-Yoon Choe, Sang-Mi Han, Cheorl-Ho Kim, Hyeun-Wook Chang, Sung-Kwon Moon, Wun-Jae Kim, Yung Hyun Choi & Young-Chae Chang. (2012) Melittin has an inhibitory effect on TNF-α-induced migration of human aortic smooth muscle cells by blocking the MMP-9 expression. Food and Chemical Toxicology 50:11, pages 3996-4002.
Crossref
Adrian Florea & Constantin Crăciun. (2012) Bee ( Apis mellifera ) Venom Produced Toxic Effects of Higher Amplitude in Rat Thoracic Aorta than in Skeletal Muscle—An Ultrastructural Study . Microscopy and Microanalysis 18:2, pages 304-316.
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Elisabeth F. Schwartz, Caroline B. F. Mourão, Karla G. Moreira, Thalita S. Camargos & Márcia R. Mortari. (2012) Arthropod venoms: A vast arsenal of insecticidal neuropeptides. Biopolymers 98:4, pages 385-405.
Crossref
Soo-Jung Kim, Ji-Hyun Park, Kyung-Hyun Kim, Woo-Ram Lee, Kee-Sik Kim & Kwan-Kyu Park. (2011) Melittin Inhibits Atherosclerosis in LPS/High-Fat Treated Mice Through Atheroprotective Actions. Journal of Atherosclerosis and Thrombosis 18:12, pages 1117-1126.
Crossref
P. Brigatte, Y. Cury, B. M. de Souza, N. B. Baptista-Saidemberg, D. M. Saidemberg, V. P. Gutierrez & Mario Sérgio Palma. (2010) Hyperalgesic and edematogenic effects of peptides isolated from the venoms of honeybee (Apis mellifera) and neotropical social wasps (Polybia paulista and Protonectarina sylveirae). Amino Acids 40:1, pages 101-111.
Crossref
Magda Descorbeth & Madhu B. Anand-Srivastava. (2010) Role of growth factor receptor transactivation in high glucose-induced increased levels of Gq/11α and signaling in vascular smooth muscle cells. Journal of Molecular and Cellular Cardiology 49:2, pages 221-233.
Crossref

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