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Journal of Toxicology and Environmental Health, Part A
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Volume 70, 2007 - Issue 15-16: Current Toxicological Issues in Korea
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Original Articles

Characterization of Human Liver Cytochrome P-450 Enzymes Involved in the O-demethylation of a New P-glycoprotein Inhibitor HM-30181Footnote∗

In Bok Paek Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University, Iksan, Republic of Korea; Research Center, Hanmi Pharm. Co. Ltd., Hwaseong, Republic of Korea
,
Sung Yeon Kim Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University, Iksan, Republic of Korea
,
Maeng Sup Kim Research Center, Hanmi Pharm. Co. Ltd., Hwaseong, Republic of Korea
,
John Kim Research Center, Hanmi Pharm. Co. Ltd., Hwaseong, Republic of Korea
,
Gwansun Lee Research Center, Hanmi Pharm. Co. Ltd., Hwaseong, Republic of Korea
&
Hye Suk Lee Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University, Iksan, Republic of KoreaCorrespondence[email protected]
Pages 1356-1364 | Published online: 24 Jul 2007

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Suneet Shukla, Chung-Pu Wu & Suresh V Ambudkar. (2008) Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges. Expert Opinion on Drug Metabolism & Toxicology 4:2, pages 205-223.
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Articles from other publishers (5)

Wen Wee Ma, Jenny J. Li, Nilofer S. Azad, Elaine T. Lam, Jennifer R. Diamond, Grace K. Dy, Mateusz Opyrchal, Jay Zhi, Douglas Kramer, Wing-Kai Chan, David Cutler, Rudolf Kwan, Alex A. Adjei & Antonio Jimeno. (2022) A phase Ib study of Oraxol (oral paclitaxel and encequidar) in patients with advanced malignancies. Cancer Chemotherapy and Pharmacology 90:1, pages 7-17.
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Tae-Eun Kim, Howard Lee, Kyoung Soo Lim, SeungHwan Lee, Seo-Hyun Yoon, Kyung-Mi Park, Hyesun Han, Sang-Goo Shin, In-Jin Jang, Kyung-Sang Yu & Joo-Youn Cho. (2014) Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. British Journal of Clinical Pharmacology 78:3, pages 556-564.
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Young Hee Choi, Seul Oh, Seo-Hyun Yoon, Tae-Eun Kim, Namyi Gu, Eun Young Kim, Han Kyong Kim, Kyung-Sang Yu, In-Jin Jang, Sang-Goo Shin & Joo-Youn Cho. (2011) Simultaneous LC–MS–MS Determination of HM30181A, [2-(2-{4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl]amide, as a new P-Glycoprotein Inhibitor and Its Two Metabolites, M1 and M2, in Human Plasma: Application to a Pharmacokinetic Study. Chromatographia 73:3-4, pages 273-280.
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Jin-Oh Kwak, Sung Hee Lee, Gwan Sun Lee, Maeng Sup Kim, Young-Gil Ahn, Ji Hyun Lee, So Won Kim, Kyung Hwan Kim & Min Goo Lee. (2010) Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel. European Journal of Pharmacology 627:1-3, pages 92-98.
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Tarik E. Ali & Silvia S. Halacheva. (2009) Synthetic approach for novel bis(α‐aminophosphonic acid) derivatives of chromone containing 1,2,4,3‐triazaphosphole moieties. Heteroatom Chemistry 20:3, pages 117-122.
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