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Original Articles

Studies of the Comparative In Vitro Toxicology of the Cyanobacterial Metabolite Deoxycylindrospermopsin

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Pages 1679-1686 | Published online: 28 Aug 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Samuel Liebel, Sonia Regina Grötzner, Daniele Dietrich Moura Costa, Marco Antônio Ferreira Randi, Ciro Alberto de Oliveira Ribeiro & Francisco Filipak Neto. (2016) Cylindrospermopsin effects on protein profile of HepG2 cells. Toxicology Mechanisms and Methods 26:7, pages 554-563.
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H. M. Liyanage, D. N. Magana Arachchi, T. Abeysekara & L. Guneratne. (2016) Toxicology of freshwater cyanobacteria. Journal of Environmental Science and Health, Part C 34:3, pages 137-168.
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SuzanneM. Froscio, Stella Fanok & AndrewR. Humpage. (2009) Cytotoxicity Screening for the Cyanobacterial Toxin Cylindrospermopsin. Journal of Toxicology and Environmental Health, Part A 72:5, pages 345-349.
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Articles from other publishers (60)

Petar Davidović, Dajana Blagojević, Jussi Meriluoto, Jelica Simeunović & Zorica Svirčev. (2023) Biotests in Cyanobacterial Toxicity Assessment—Efficient Enough or Not?. Biology 12:5, pages 711.
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María G. Hinojosa, Antonio Cascajosa-Lira, Ana I. Prieto, Daniel Gutiérrez-Praena, Vitor Vasconcelos, Angeles Jos & Ana M. Cameán. (2023) Cytotoxic Effects and Oxidative Stress Produced by a Cyanobacterial Cylindrospermopsin Producer Extract versus a Cylindrospermopsin Non-Producing Extract on the Neuroblastoma SH-SY5Y Cell Line. Toxins 15:5, pages 320.
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Jiangbing Qiu, Jingrui Zhang & Aifeng Li. (2023) Cytotoxicity and intestinal permeability of phycotoxins assessed by the human Caco-2 cell model. Ecotoxicology and Environmental Safety 249, pages 114447.
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Olasunkanmi S. Olawuwo, Ibukun M. Famuyide & Lyndy J. McGaw. (2022) Antibacterial and Antibiofilm Activity of Selected Medicinal Plant Leaf Extracts Against Pathogens Implicated in Poultry Diseases. Frontiers in Veterinary Science 9.
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Abhishek Chauhan, Anuj Ranjan, Rupesh Kumar Basniwal & Tanu Jindal. 2022. New Frontiers in Environmental Toxicology. New Frontiers in Environmental Toxicology 23 34 .
Thida Swe, Christopher O. Miles, Leonardo Cerasino, Marit Mjelde, Synne Kleiven & Andreas Ballot. (2021) Microcystis, Raphidiopsis raciborskii and Dolichospermum smithii, toxin producing and non-toxigenic cyanobacteria in Yezin Dam, Myanmar. Limnologica 90, pages 125901.
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Erika Berenice Martínez-Ruiz, Myriel Cooper, Munir A. Al-Zeer, Jens Kurreck, Lorenz Adrian & Ulrich Szewzyk. (2020) Manganese-oxidizing bacteria form multiple cylindrospermopsin transformation products with reduced human liver cell toxicity. Science of The Total Environment 729, pages 138924.
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Carlos González-Blanco, Felipe Augusto Dörr, Renata Albuquerque, Janice Onuki & Ernani Pinto. (2020) Alternative Isolation Protocol for Desulfo and Zwitterionic Cylindrospermopsin Alkaloids and Comparison of Their Toxicity in HepG2 Cells. Molecules 25:13, pages 3027.
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Andreas Ballot, Thida Swe, Marit Mjelde, Leonardo Cerasino, Vladyslava Hostyeva & Christopher O. Miles. (2020) Cylindrospermopsin- and Deoxycylindrospermopsin-Producing Raphidiopsis raciborskii and Microcystin-Producing Microcystis spp. in Meiktila Lake, Myanmar. Toxins 12:4, pages 232.
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LU Yan, LEI Minting, YE Jinmei, LEI Lamei & HAN Boping. (2020) Intraspecific variation of morphological traits and toxin-producing capacity and phylogenetic analysis for <i>Cylindrospermopsis raciborskii</i> from Qiandenghu Lake, Guangdong Province. Journal of Lake Sciences 32:1, pages 144-153.
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Michal Adamski, Paweł Żmudzki, Jan Bialczyk, Ariel Kaminski, Ewelina Chrapusta-Srebrny, Beata Bober & Kornelia Duchnik. (2019) Decomposition products of cylindrospermopsin – a cyanotoxin produced by Raphidiopsis raciborskii (Woloszynska) . Oceanological and Hydrobiological Studies 48:3, pages 227-235.
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Jan Raška, Lucie Čtveráčková, Aneta Dydowiczová, Iva Sovadinová, Luděk Bláha & Pavel Babica. (2019) Cylindrospermopsin induces cellular stress and activation of ERK1/2 and p38 MAPK pathways in adult human liver stem cells. Chemosphere 227, pages 43-52.
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I-Shuo Huang & Paul V. Zimba. (2019) Cyanobacterial bioactive metabolites—A review of their chemistry and biology. Harmful Algae 86, pages 139-209.
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Barbara Kubickova, Petra Laboha, Jan-Peter Hildebrandt, Klara Hilscherová & Pavel Babica. (2019) Effects of cylindrospermopsin on cultured immortalized human airway epithelial cells. Chemosphere 220, pages 620-628.
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Tereza Vanova, Jan Raska, Pavel Babica, Iva Sovadinova, Michaela Kunova Bosakova, Petr Dvorak, Ludek Blaha & Vladimir Rotrekl. (2019) Freshwater Cyanotoxin Cylindrospermopsin Has Detrimental Stage-specific Effects on Hepatic Differentiation From Human Embryonic Stem Cells. Toxicological Sciences 168:1, pages 241-251.
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I-Shuo Huang & Paul V. Zimba. (2019) Cyanobacterial bioactive metabolites—A review of their chemistry and biology. Harmful Algae 83, pages 42-94.
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Daniel Gutiérrez-Praena, Remedios Guzmán-Guillén, Silvia Pichardo, Francisco Javier Moreno, Vitor Vasconcelos, Ángeles Jos & Ana María Cameán. (2019) Cytotoxic and morphological effects of microcystin-LR, cylindrospermopsin, and their combinations on the human hepatic cell line HepG2. Environmental Toxicology 34:3, pages 240-251.
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Amrita Basu, Aneta Dydowiczová, Lucie Čtveráčková, Libor Jaša, James E. Trosko, Luděk Bláha & Pavel Babica. (2018) Assessment of Hepatotoxic Potential of Cyanobacterial Toxins Using 3D In Vitro Model of Adult Human Liver Stem Cells. Environmental Science & Technology 52:17, pages 10078-10088.
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Philip T. Orr, Anusuya Willis & Michele A. Burford. (2018) Application of first order rate kinetics to explain changes in bloom toxicity—the importance of understanding cell toxin quotas. Journal of Oceanology and Limnology 36:4, pages 1063-1074.
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T. Papadimitriou, M. Katsiapi, K. Vlachopoulos, A. Christopoulos, C. Laspidou, M. Moustaka-Gouni & K. Kormas. (2018) Cyanotoxins as the “common suspects” for the Dalmatian pelican (Pelecanus crispus) deaths in a Mediterranean reconstructed reservoir. Environmental Pollution 234, pages 779-787.
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Silvia Pichardo, Ana Cameán & Angeles Jos. (2017) In Vitro Toxicological Assessment of Cylindrospermopsin: A Review. Toxins 9:12, pages 402.
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Christopher Cartmell, Daniel M. Evans, Jessica M.L. Elwood, Hisham S. Fituri, Patrick J. Murphy, Thomas Caspari, Barbara Poniedziałek & Piotr Rzymski. (2017) Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. Toxicology in Vitro 44, pages 172-181.
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R. C. Silva, S. Liebel, H. H. P. de Oliveira, W. A. Ramsdorf, J. R. E. Garcia, S. M. F. O. Azevedo, V. F. Magalhães, C. A. Oliveira Ribeiro & F. Filipak Neto. (2017) Cylindrospermopsin effects on cell viability and redox milieu of Neotropical fish Hoplias malabaricus hepatocytes. Fish Physiology and Biochemistry 43:5, pages 1237-1244.
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Thi Thu Lien Nguyen, Tien Hien Hoang, Trung Kien Nguyen & Thi Thuy Duong. (2017) The occurrence of toxic cyanobacterium Cylindrospermopsis raciborskii and its toxin cylindrospermopsin in the Huong River, Thua Thien Hue province, Vietnam. Environmental Monitoring and Assessment 189:10.
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Todd Miller, Lucas Beversdorf, Chelsea Weirich & Sarah Bartlett. (2017) Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water. Marine Drugs 15:6, pages 160.
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Rachana Singh, Parul Parihar, Madhulika Singh, Andrzej Bajguz, Jitendra Kumar, Samiksha Singh, Vijay P. Singh & Sheo M. Prasad. (2017) Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects. Frontiers in Microbiology 8.
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LI Hongmin, PEI Haiyan, SUN Jiongming, JIN Yan & XU Hangzhou. (2017) Progress and prospect in the study of <i>Cylindrospermopsis raciborskii</i> and its toxins. Journal of Lake Sciences 29:4, pages 775-795.
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Michal Adamski, Paweł Żmudzki, Ewelina Chrapusta, Ariel Kaminski, Beata Bober, Kornelia Zabaglo & Jan Bialczyk. (2016) Characterization of cylindrospermopsin decomposition products formed under irradiation conditions. Algal Research 18, pages 1-6.
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Carlos Pinheiro, Joana Azevedo, Alexandre Campos, Vítor Vasconcelos & Susana Loureiro. (2016) The interactive effects of microcystin-LR and cylindrospermopsin on the growth rate of the freshwater algae Chlorella vulgaris. Ecotoxicology 25:4, pages 745-758.
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Michele A. Burford, John Beardall, Anusuya Willis, Philip T. Orr, Valeria F. Magalhaes, Luciana M. Rangel, Sandra M.F.O.E. Azevedo & Brett A. Neilan. (2016) Understanding the winning strategies used by the bloom-forming cyanobacterium Cylindrospermopsis raciborskii. Harmful Algae 54, pages 44-53.
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Rajesh P. Rastogi, Datta Madamwar & Aran Incharoensakdi. (2015) Bloom Dynamics of Cyanobacteria and Their Toxins: Environmental Health Impacts and Mitigation Strategies. Frontiers in Microbiology 6.
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Samuel Liebel, Ciro Alberto de Oliveira Ribeiro, Valéria Freitas de Magalhães, Rodrigo de Cássio da Silva, Stéfani Cibele Rossi, Marco Antônio Ferreira Randi & Francisco Filipak Neto. (2015) Low concentrations of cylindrospermopsin induce increases of reactive oxygen species levels, metabolism and proliferation in human hepatoma cells (HepG2). Toxicology in Vitro 29:3, pages 479-488.
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Juan A. Rubiolo, Diego Alberto Fernández, Henar López & M. Carmen Louzao. 2015. Phycotoxins. Phycotoxins 317 341 .
Michał Adamski, Ewelina Chrapusta, Beata Bober, Ariel Kamiński & Jan Białczyk. (2014) Cylindrospermopsin: cyanobacterial secondary metabolite. Biological aspects and potential risk for human health and life. Oceanological and Hydrobiological Studies 43:4, pages 442-449.
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Karina Preußel, Ingrid Chorus & Jutta Fastner. (2014) Nitrogen Limitation Promotes Accumulation and Suppresses Release of Cylindrospermopsins in Cells of Aphanizomenon Sp.. Toxins 6:10, pages 2932-2947.
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Xuexiang He, Geshan Zhang, Armah A. de la Cruz, Kevin E. O’Shea & Dionysios D. Dionysiou. (2014) Degradation Mechanism of Cyanobacterial Toxin Cylindrospermopsin by Hydroxyl Radicals in Homogeneous UV/H 2 O 2 Process . Environmental Science & Technology 48:8, pages 4495-4504.
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Anastasia Hiskia, Theodoros M. Triantis, Maria G. Antoniou, Armah A. de la Cruz, Kevin O'Shea, Weihua Song, Theodora Fotiou, Triantafyllos Kaloudis, Xuexiang He, Joel Andersen & Dionysios D. Dionysiou. 2014. Transformation Products of Emerging Contaminants in the Environment. Transformation Products of Emerging Contaminants in the Environment 675 708 .
Leigh Stitz, Susan Kinnear & Larelle Fabbro. (2013) A role for aeration and intake depth in managing toxic Cylindrospermopsis : A comparison between off‐stream and riverine environments in the Fitzroy Basin, Australia . Lakes & Reservoirs: Science, Policy and Management for Sustainable Use 18:2, pages 179-196.
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C. Moreira, J. Azevedo, A. Antunes & V. Vasconcelos. (2013) Cylindrospermopsin: occurrence, methods of detection and toxicology. Journal of Applied Microbiology 114:3, pages 605-620.
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Daniel Gutiérrez-Praena, Ángeles Jos, Silvia Pichardo, Isabel M. Moreno & Ana M. Cameán. (2013) Presence and bioaccumulation of microcystins and cylindrospermopsin in food and the effectiveness of some cooking techniques at decreasing their concentrations: A review. Food and Chemical Toxicology 53, pages 139-152.
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Armah A. de la Cruz, Anastasia Hiskia, Triantafyllos Kaloudis, Neil Chernoff, Donna Hill, Maria G. Antoniou, Xuexiang He, Keith Loftin, Kevin O'Shea, Cen Zhao, Miguel Pelaez, Changseok Han, Trevor J. Lynch & Dionysios D. Dionysiou. (2013) A review on cylindrospermopsin: the global occurrence, detection, toxicity and degradation of a potent cyanotoxin. Environmental Science: Processes & Impacts 15:11, pages 1979.
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Barbara Poniedziałek, Piotr Rzymski & Mikołaj Kokociński. (2012) Cylindrospermopsin: Water-linked potential threat to human health in Europe. Environmental Toxicology and Pharmacology 34:3, pages 651-660.
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Daniel Gutiérrez-Praena, Silvia Pichardo, Ángeles Jos, F. Javier Moreno & Ana María Cameán. (2012) Alterations observed in the endothelial HUVEC cell line exposed to pure Cylindrospermopsin. Chemosphere 89:9, pages 1151-1160.
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Vishal Gupta & Radha Prasanna. (2012) WITHDRAWN: Cyanobacterial bioactive molecules – Biosynthesis and genetic regulation. Microbiological Research.
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Daniel Gutiérrez-Praena, Silvia Pichardo, Ángeles Jos, F. Javier Moreno & Ana María Cameán. (2012) Biochemical and pathological toxic effects induced by the cyanotoxin Cylindrospermopsin on the human cell line Caco-2. Water Research 46:5, pages 1566-1575.
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Vanora Mulvenna, Katie Dale, Brian Priestly, Utz Mueller, Andrew Humpage, Glen Shaw, Graeme Allinson & Ian Falconer. (2012) Health Risk Assessment for Cyanobacterial Toxins in Seafood. International Journal of Environmental Research and Public Health 9:3, pages 807-820.
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Ángel Barón-Sola, Youness Ouahid & Francisca F. del Campo. (2012) Detection of potentially producing cylindrospermopsin and microcystin strains in mixed populations of cyanobacteria by simultaneous amplification of cylindrospermopsin and microcystin gene regions. Ecotoxicology and Environmental Safety 75, pages 102-108.
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