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Original Articles

Biomarkers of Metal Toxicity in Population Studies: Research Potential and Interpretation Issues

Pages 1259-1265 | Published online: 06 Aug 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Vasco Branco, Sam Caito, Marcelo Farina, João Teixeira da Rocha, Michael Aschner & Cristina Carvalho. (2017) Biomarkers of mercury toxicity: Past, present, and future trends. Journal of Toxicology and Environmental Health, Part B 20:3, pages 119-154.
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Katarzyna Byber, Dominique Lison, Violaine Verougstraete, Holger Dressel & Philipp Hotz. (2016) Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review. Critical Reviews in Toxicology 46:3, pages 191-240.
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Lulzim Zeneli, Ankica Sekovanić & Nexhat Daci. (2015) Chronic exposure to aluminum, nickel, thallium and uranium and their relationship with essential elements in human whole blood and blood serum. Journal of Environmental Science and Health, Part A 50:6, pages 540-546.
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Kátia Cristina de Marco, Gilberto U. Braga & Fernando Barbosa Jr.. (2011) Determination of the Effects of eNOS Gene Polymorphisms (T-786C and Glu298Asp) on Nitric Oxide Levels in a Methylmercury-Exposed Population. Journal of Toxicology and Environmental Health, Part A 74:20, pages 1323-1333.
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Juliana A. Nunes, Bruno L. Batista, Jairo L. Rodrigues, Naise M. Caldas, José A. G. Neto & Fernando Barbosa$suffix/text()$suffix/text(). (2010) A Simple Method Based on ICP-MS for Estimation of Background Levels of Arsenic, Cadmium, Copper, Manganese, Nickel, Lead, and Selenium in Blood of the Brazilian Population. Journal of Toxicology and Environmental Health, Part A 73:13-14, pages 878-887.
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Nahida Haddam, Sekkal Samira, Xavier Dumont, Abdesselem Taleb, Vincent Haufroid, Dominique Lison & Alfred Bernard. (2009) Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter. Biomarkers 14:5, pages 292-298.
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Articles from other publishers (43)

Shaikh Mohammad Bokhtiar, Mohammad Rafiqul Islam, Md. Jisan Ahmed, Abdur Rahman & Kazi Rafiq. (2023) Assessment of Heavy Metals Contamination and Antimicrobial Drugs Residue in Broiler Edible Tissues in Bangladesh. Antibiotics 12:4, pages 662.
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Y. M. Tuakashikila, H. M. Mata, M. M. Kabamba, A. M. Malumba & J. K. Tuakuila. (2023) Reference intervals for cd, hg, Mn and Pb in the general children population (3–14 years) of Kinshasa, Democratic Republic of Congo (DRC) between June 2019 and June 2020. Archives of Public Health 81:1.
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Jitendra Kumar Sahoo, Prathap Somu, Saranya Narayanasamy, Shraban Kumar Sahoo, Yong Rok Lee, D.R. Baalakrishnan, N.V. RajaSekhar Reddy & S. Rajendiran. (2023) WITHDRAWN: Heavy metal ions and dyes removal from aqueous solution using Aloevera-based biosorbent: A systematic review. Environmental Research 216, pages 114669.
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Didier Sierra, Alfonso Cubillos-Varela & Carlos Franco. (2022) Analysis of sugarcane production and transportation in Hoya del Río Suárez from a life cycle perspective. Clean Technologies and Environmental Policy 24:10, pages 3303-3315.
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María Elena Calderon-Segura, Alejandro Ramírez-Guzmán, Oscar Talavera-Mendoza, Yolanda Carbajal-López, María del Carmen Martínez-Valenzuela, Martha Elena Mora-Herrera, Liliana Salinas-Alcántara & Patricia Hurtado-Brito. (2022) Genotoxic Biomonitoring in Children Living near the El Fraile Mine Tailings in Northern Guerrero State, Mexico. Toxics 10:11, pages 674.
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Katherine von Stackelberg, Pamela R. D. Williams, Ernesto Sánchez-Triana & Santiago EnriquezKatherine von Stackelberg, Pamela R. D. Williams, Ernesto Sánchez-Triana, Santiago Enriquez & Claudia Serrano. 2022. Recycling of Used Lead-Acid Batteries: Guidelines for Appraisal of Environmental Health Impacts. Recycling of Used Lead-Acid Batteries: Guidelines for Appraisal of Environmental Health Impacts 55 100 .
Katherine von Stackelberg, Pamela R. D. Williams & Ernesto Sánchez-TrianaKatherine von Stackelberg, Pamela R. D. Williams & Ernesto Sánchez-Triana. 2022. Artisanal Small-Scale Gold Mining: A Framework for Collecting Site-Specific Sampling and Survey Data to Support Health-Impact Analyses. Artisanal Small-Scale Gold Mining: A Framework for Collecting Site-Specific Sampling and Survey Data to Support Health-Impact Analyses 53 109 .
Ang Li, Jiaxin Zhao, Liu Liu, Yayuan Mei, Quan Zhou, Meiduo Zhao, Jing Xu, Xiaoyu Ge & Qun Xu. (2022) Association of Metals and Metalloids With Urinary Albumin/Creatinine Ratio: Evidence From a Cross-Sectional Study Among Elderly in Beijing. Frontiers in Public Health 10.
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Martin M. Kabamba, Honoré N. Mata, Crispin K. Mulaji, François B. Mbuyi, Jean-Pierre M. Elongi & Joel K. Tuakuila. (2021) Human biomonitoring in the Democratic Republic of Congo (DRC): A systematic review. Scientific African 13, pages e00906.
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Simona Ioana Vicas, Vasile Laslo, Adrian Vasile Timar, Cornel Balta, Hildegard Herman, Alina Ciceu, Sami Gharbia, Marcel Rosu, Bianca Mladin, Luminita Fritea, Simona Cavalu, Coralia Cotoraci, József Prokisch, Maria Puschita, Calin Pop, Eftimie Miutescu & Anca Hermenean. (2021) Functional Food Product Based on Nanoselenium-Enriched Lactobacillus casei against Cadmium Kidney Toxicity. Applied Sciences 11:9, pages 4220.
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Katherine von Stackelberg, Pamela R.D. Williams & Ernesto Sánchez-Triana. (2021) A Systematic Framework for Collecting Site-Specific Sampling and Survey Data to Support Analyses of Health Impacts from Land-Based Pollution in Low- and Middle-Income Countries. International Journal of Environmental Research and Public Health 18:9, pages 4676.
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Suparna Pal. 2021. Recent Advancements in Bioremediation of Metal Contaminants. Recent Advancements in Bioremediation of Metal Contaminants 126 146 .
Arce Domingo-Relloso, Maria Grau-Perez, Laisa Briongos-Figuero, Jose L Gomez-Ariza, Tamara Garcia-Barrera, Antonio Dueñas-Laita, Jennifer F Bobb, F Javier Chaves, Marianthi-Anna Kioumourtzoglou, Ana Navas-Acien, Josep Redon-Mas, Juan C Martin-Escudero & Maria Tellez-Plaza. (2019) The association of urine metals and metal mixtures with cardiovascular incidence in an adult population from Spain: the Hortega Follow-Up Study. International Journal of Epidemiology 48:6, pages 1839-1849.
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Mathieu Valcke, Nathalie Ouellet, Marjolaine Dubé, Elhadji A. Laouan Sidi, Alain LeBlanc, Louise Normandin, Cynthia Balion & Pierre Ayotte. (2019) Biomarkers of cadmium, lead and mercury exposure in relation with early biomarkers of renal dysfunction and diabetes: Results from a pilot study among aging Canadians. Toxicology Letters 312, pages 148-156.
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Rufeng Jin, Xiangzhu Zhu, Martha J. Shrubsole, Chang Yu, Zhaolin Xia & Qi Dai. (2018) Associations of renal function with urinary excretion of metals: Evidence from NHANES 2003–2012. Environment International 121, pages 1355-1362.
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Marina dos Santos, Maria Cristina Flores Soares, Paulo Roberto Martins Baisch, Ana Luíza Muccillo Baisch & Flavio Manoel Rodrigues da Silva Júnior. (2018) Biomonitoring of trace elements in urine samples of children from a coal-mining region. Chemosphere 197, pages 622-626.
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Hongyu Wang, Xavier Dumont, Vincent Haufroid & Alfred Bernard. (2017) The physiological determinants of low-level urine cadmium: an assessment in a cross-sectional study among schoolchildren. Environmental Health 16:1.
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Yanhua Gao, Yanfang Zhang, Juan Yi, Jinpeng Zhou, Xianqing Huang, Xinshan Shi, Shunhua Xiao & Dafeng Lin. (2016) A longitudinal study on urinary cadmium and renal tubular protein excretion of nickel–cadmium battery workers after cessation of cadmium exposure. International Archives of Occupational and Environmental Health 89:7, pages 1137-1145.
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Jia Hu, Mei Li, Tian-xu Han, Jian-wei Chen, Lin-xiang Ye, Qi Wang & Yi-kai Zhou. (2014) Benchmark Dose Estimation for Cadmium-Induced Renal Tubular Damage among Environmental Cadmium-Exposed Women Aged 35–54 Years in Two Counties of China. PLoS ONE 9:12, pages e115794.
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Vanda Andrade, M. Luísa Mateus, M. Camila Batoréu, Michael Aschner & A.P. Marreilha dos Santos. (2014) Changes in rat urinary porphyrin profiles predict the magnitude of the neurotoxic effects induced by a mixture of lead, arsenic and manganese. NeuroToxicology 45, pages 168-177.
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Yongfeng Tian, Hongwei Hou, Fengpeng Zhu, An Wang, Yong Liu & Qingyuan Hu. (2014) Simultaneous Determination of Chromium, Cadmium, and Lead and Evaluation of the Correlation between Chromium and Cotinine in Chinese Smokers. Biological Trace Element Research 158:1, pages 9-14.
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Patricia Mussali-Galante, Efraín Tovar-Sánchez, Mahara Valverde & Emilio Rojas. 2014. Reviews of Environmental Contamination and Toxicology, Volume 227. Reviews of Environmental Contamination and Toxicology, Volume 227 79 106 .
Maria Wallin, Gerd Sallsten, Elisabeth Fabricius-Lagging, Christian Öhrn, Thomas Lundh & Lars Barregard. (2013) Kidney cadmium levels and associations with urinary calcium and bone mineral density: a cross-sectional study in Sweden. Environmental Health 12:1.
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Patricia Mussali-Galante, Efraín Tovar-Sánchez, Mahara Valverde, Leticia Valencia-Cuevas & E. Rojas. (2012) Evidence of population genetic effects in Peromyscus melanophrys chronically exposed to mine tailings in Morelos, Mexico. Environmental Science and Pollution Research 20:11, pages 7666-7679.
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R. Hambach, D. Lison, P.C. D’Haese, J. Weyler, E. De Graef, A. De Schryver, L.V. Lamberts & M. van Sprundel. (2013) Co-exposure to lead increases the renal response to low levels of cadmium in metallurgy workers. Toxicology Letters 222:2, pages 233-238.
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Mingai Huang, Seong-Jin Choi, Dong-Won Kim, Na-Young Kim, Hye-Sun Bae, Seung-Do Yu, Dae-Seon Kim, Heon Kim, Byung-Sun Choi, Il-Je Yu & Jung-Duck Park. (2013) Evaluation of factors associated with cadmium exposure and kidney function in the general population. Environmental Toxicology 28:10, pages 563-570.
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Yang Wang, Yuchen Wu, Kang Luo, Yuxin Liu, Ming Zhou, Shu Yan, Hui Shi & Yunqing Cai. (2013) The protective effects of selenium on cadmium-induced oxidative stress and apoptosis via mitochondria pathway in mice kidney. Food and Chemical Toxicology 58, pages 61-67.
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Alessandra Pedriali, Consuelo Riva, Marco Parolini, Simone Cristoni, David Sheehan & Andrea Binelli. (2012) A redox proteomic investigation of oxidative stress caused by benzoylecgonine in the freshwater bivalve Dreissena polymorpha . Drug Testing and Analysis 5:8, pages 646-656.
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Magnus Akerstrom, Lars Barregard, Thomas Lundh & Gerd Sallsten. (2013) The relationship between cadmium in kidney and cadmium in urine and blood in an environmentally exposed population. Toxicology and Applied Pharmacology 268:3, pages 286-293.
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Magnus Akerstrom, Gerd Sallsten, Thomas Lundh & Lars Barregard. (2013) Associations between Urinary Excretion of Cadmium and Proteins in a Nonsmoking Population: Renal Toxicity or Normal Physiology?. Environmental Health Perspectives 121:2, pages 187-191.
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S.J.S. Flora. 2013. Comprehensive Inorganic Chemistry II. Comprehensive Inorganic Chemistry II 987 1013 .
Sonoko Sakuragi, Ken Takahashi, Tsutomu Hoshuyama, Jiro Moriguchi, Fumiko Ohashi, Yoshinari Fukui & Masayuki Ikeda. (2012) Variation in benchmark dose (BMD) and the 95% lower confidence limit of benchmark dose (BMDL) among general Japanese populations with no anthropogenic exposure to cadmium. International Archives of Occupational and Environmental Health 85:8, pages 941-950.
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Agnès Chaumont, Marc Nickmilder, Xavier Dumont, Thomas Lundh, Staffan Skerfving & Alfred Bernard. (2012) Associations between proteins and heavy metals in urine at low environmental exposures: Evidence of reverse causality. Toxicology Letters 210:3, pages 345-352.
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Františka Hrubá, Ulf Strömberg, Milena Černá, Chunying Chen, Florencia Harari, Raúl Harari, Milena Horvat, Kvetoslava Koppová, Andreja Kos, Andrea Krsková, Mladen Krsnik, Jawhar Laamech, Yu-Feng Li, Lina Löfmark, Thomas Lundh, Nils-Göran Lundström, Badiaa Lyoussi, Darja Mazej, Joško Osredkar, Krystyna Pawlas, Natalia Pawlas, Adam Prokopowicz, Gerda Rentschler, Věra Spěváčková, Zdravko Spiric, Janja Tratnik, Staffan Skerfving & Ingvar A. Bergdahl. (2012) Blood cadmium, mercury, and lead in children: An international comparison of cities in six European countries, and China, Ecuador, and Morocco. Environment International 41, pages 29-34.
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Masayuki Ikeda, Jiro Moriguchi, Sonoko Sakuragi & Fumiko Ohashi. (2011) Bi-linear dose–response relationship in general populations with low-level cadmium exposures in non-polluted areas in Japan. International Archives of Occupational and Environmental Health 85:4, pages 427-435.
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Nahida Haddam, Sekkal Samira, Xavier Dumont, Abdesselem Taleb, Dominique Lison, Vincent Haufroid & Alfred Bernard. (2011) Confounders in the assessment of the renal effects associated with low-level urinary cadmium: an analysis in industrial workers. Environmental Health 10:1.
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Masayuki Ikeda, Yasunari Fukui, Fumiko Ohashi, Sonoko Sakuragi & Jiro Moriguchi. (2010) Low Cadmium Levels in Urine of Residents in two Prefectures where Cadmium Levels in Locally Harvested Brown Rice are Higher than in other Prefectures in Japan. Biological Trace Element Research 139:2, pages 217-227.
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Masayuki Ikeda, Fumiko Ohashi, Yoshinari Fukui, Sonoko Sakuragi & Jiro Moriguchi. (2010) Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan. International Archives of Occupational and Environmental Health 84:2, pages 121-129.
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Mi-Sun Lee, Sung Kyun Park, Howard Hu & Sundong Lee. (2011) Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey. Environmental Research 111:1, pages 171-176.
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Nikhil Johri, Grégory Jacquillet & Robert Unwin. (2010) Heavy metal poisoning: the effects of cadmium on the kidney. BioMetals 23:5, pages 783-792.
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Maria Stefania Sinicropi, Diana Amantea, Anna Caruso & Carmela Saturnino. (2010) Chemical and biological properties of toxic metals and use of chelating agents for the pharmacological treatment of metal poisoning. Archives of Toxicology 84:7, pages 501-520.
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Jiro Moriguchi, Yoshiro Inoue, Sigetosi Kamiyama, Sonoko Sakuragi, Masaru Horiguchi, Katsuyuki Murata, Yoshinari Fukui, Fumiko Ohashi & Masayuki Ikeda. (2009) Cadmium and tubular dysfunction marker levels in urine of residents in non-polluted areas with natural abundance of cadmium in Japan. International Archives of Occupational and Environmental Health 83:4, pages 455-466.
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Virginie Gillardin, Frédéric Silvestre, Marc Dieu, Edouard Delaive, Martine Raes, Jean-Pierre Thomé & Patrick Kestemont. (2009) Protein Expression Profiling in the African Clawed Frog Xenopus laevis Tadpoles Exposed to the Polychlorinated Biphenyl Mixture Aroclor 1254. Molecular & Cellular Proteomics 8:4, pages 596-611.
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