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Original Articles

The Role of p53 in Silica-Induced Cellular and Molecular Responses Associated with Carcinogenesis

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Pages 1509-1519 | Received 10 Mar 2009, Accepted 15 May 2009, Published online: 02 Nov 2009

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Read on this site (4)

Breanne Y. Farris, James M. Antonini, Jeffrey S. Fedan, Robert R. Mercer, Katherine A. Roach, Bean T. Chen, Diane Schwegler-Berry, Michael L. Kashon, Mark W. Barger & Jenny R. Roberts. (2017) Pulmonary toxicity following acute coexposures to diesel particulate matter and α-quartz crystalline silica in the Sprague-Dawley rat. Inhalation Toxicology 29:7, pages 322-339.
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Lili Jiang, Jihong Chang, Qingfu Zhang, Limei Sun & Xueshan Qiu. (2013) MicroRNA Hsa-miR-125a-3p Activates p53 and Induces Apoptosis in Lung Cancer Cells. Cancer Investigation 31:8, pages 538-544.
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Lili Jiang, Qin Huang, Jihong Chang, Enhua Wang & Xueshan Qiu. (2011) MicroRNA HSA-miR-125a-5p induces apoptosis by activating p53 in lung cancer cells. Experimental Lung Research 37:7, pages 387-398.
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Articles from other publishers (14)

Cigdem Keles & Emily Sarver. (2022) A Study of Respirable Silica in Underground Coal Mines: Particle Characteristics. Minerals 12:12, pages 1555.
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Xinru Pang, Haojun Shi, Xiaoshu Chen, Chao Li, Bin Shi, Abrey J. Yeo, Martin F. Lavin, Qiang Jia, Hua Shao, Juan Zhang & Gongchang Yu. (2022) miRNA ‐34c‐5p targets Fra‐1 to inhibit pulmonary fibrosis induced by silica through p53 and PTEN / PI3K /Akt signaling pathway . Environmental Toxicology 37:8, pages 2019-2032.
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Riccardo Leinardi, Chiara Longo Sanchez-Calero & François Huaux. (2022) Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development. Frontiers in Toxicology 4.
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Krystyna Maciaszek, David M. Brown & Vicki Stone. (2022) An in vitro assessment of the toxicity of two-dimensional synthetic and natural layered silicates. Toxicology in Vitro 78, pages 105273.
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Kelly Fraser, Vamsi Kodali, Naveena Yanamala, M. Eileen Birch, Lorenzo Cena, Gary Casuccio, Kristin Bunker, Traci L. Lersch, Douglas E. Evans, Aleksandr Stefaniak, Mary Ann Hammer, Michael L. Kashon, Theresa Boots, Tracy Eye, John Hubczak, Sherri A. Friend, Matthew Dahm, Mary K. Schubauer-Berigan, Katelyn Siegrist, David Lowry, Alison K. Bauer, Linda M. Sargent & Aaron Erdely. (2020) Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities. Particle and Fibre Toxicology 17:1.
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Nicole S. Olgun, Anna M. Morris, Aleksandr B. Stefaniak, Lauren N. Bowers, Alycia K. Knepp, Matthew G. Duling, Robert R. Mercer, Michael L. Kashon, Jeffrey S. Fedan & Stephen S. Leonard. (2020) Biological effects of inhaled hydraulic fracturing sand dust. III. Cytotoxicity and pro-inflammatory responses in cultured murine macrophage cells. Toxicology and Applied Pharmacology 408, pages 115281.
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Paul J. A. Borm, Paul Fowler & David Kirkland. (2018) An updated review of the genotoxicity of respirable crystalline silica. Particle and Fibre Toxicology 15:1.
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Cinzia Antognelli, Angela Gambelunghe, Giacomo Muzi & Vincenzo Nicola Talesa. (2016) Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: Transformation into a neoplastic-like phenotype. Free Radical Biology and Medicine 92, pages 110-125.
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Cinzia Antognelli, Angela Gambelunghe, Giacomo Muzi & Vincenzo Nicola Talesa. (2015) Peroxynitrite-mediated glyoxalase I epigenetic inhibition drives apoptosis in airway epithelial cells exposed to crystalline silica via a novel mechanism involving argpyrimidine-modified Hsp70, JNK, and NF-κB. Free Radical Biology and Medicine 84, pages 128-141.
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Ha Ryong Kim, Da Young Shin, Yong Joo Park, Chang We Park, Seung Min Oh & Kyu Hyuck Chung. (2014) Silver nanoparticles induce p53-mediated apoptosis in human bronchial epithelial (BEAS-2B) cells. The Journal of Toxicological Sciences 39:3, pages 401-412.
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T.N. Perkins, P.M. Peeters, E.F.M. Wouters, N.L. Reynaert & B.T. Mossman. 2014. Pathobiology of Human Disease. Pathobiology of Human Disease 2654 2664 .
Ha Ryong Kim, Bo Hee Son, Soo Yeun Lee, Kyu Hyuck Chung & Seung Min Oh. (2012) The Role of p53 in Marijuana Smoke Condensates-induced Genotoxicity and Apoptosis. Environmental Health and Toxicology 27, pages e2012017.
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Jennifer Kasper, Maria I Hermanns, Christoph Bantz, Michael Maskos, Roland Stauber, Christine Pohl, Ronald E Unger & James C Kirkpatrick. (2011) Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: Comparison with conventional monocultures. Particle and Fibre Toxicology 8:1.
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Elijah J. Petersen & Bryant C. Nelson. (2010) Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA. Analytical and Bioanalytical Chemistry 398:2, pages 613-650.
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