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Articles

Comparative Toxicological Evaluation of Phthalate Diesters and Metabolites in Sprague-Dawley Male Rats for Risk Assessment

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Pages 1446-1454 | Published online: 29 Dec 2009

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Bu Young Chung, Seul Min Choi, Tae Hyun Roh, Duck Soo Lim, Mi Young Ahn, Yeon Joo Kim, Hyung Sik Kim & Byung-Mu Lee. (2019) Risk assessment of phthalates in pharmaceuticals. Journal of Toxicology and Environmental Health, Part A 82:5, pages 351-360.
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Jiaqin Bao, Min Wang, Xiaojun Ning, Yaobin Zhou, Yuping He, Jielin Yang, Xi Gao, Shuguang Li, Zhuoping Ding & Bo Chen. (2015) Phthalate Concentrations in Personal Care Products and the Cumulative Exposure to Female Adults and Infants in Shanghai. Journal of Toxicology and Environmental Health, Part A 78:5, pages 325-341.
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Guisheng Zhang & Yilei Wang. (2014) Genotoxic effects of diethyl phthalate on the non-specific immune function of carp. Toxin Reviews 33:4, pages 139-145.
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Kazeem A. Akinwumi. (2019) Vitamin E Alleviates Diethylhexyl Phthalate-Induced Haemato-logical Changes and Splenic Oxidative Injury in Male Sprague-Dawley Rats. Journal of Cancer Research Updates 8:1, pages 42-51.
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Muhammad Junaid, Pan-Pan Jia, Yu-Mei Tang, Wen-Xu Xiong, Hai-Yang Huang, Phyllis R. Strauss, Wei-Guo Li & De-Sheng Pei. (2018) Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China. Environmental Pollution 242, pages 1939-1949.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1195 1271 .
Hai-Tao Gao, Run Xu, Wei-Xin Cao, Qian-Nan Di, Rui-Xian Li, Lingeng Lu, Qian Xu & Shu-Qin Yu. (2018) Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats. Toxicology and Applied Pharmacology 341, pages 87-97.
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Pan Yang, Ya-Jie Gong, Yi-Xin Wang, Xin-Xiu Liang, Qing Liu, Chong Liu, Ying-Jun Chen, Li Sun, Wen-Qing Lu & Qiang Zeng. (2017) Effect modification by apoptosis-related gene polymorphisms on the associations of phthalate exposure with spermatozoa apoptosis and semen quality. Environmental Pollution 231, pages 694-702.
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Songwen Tan, Donglin Wang, Zhenxing Chi, Weiguo Li & Ye Shan. (2017) Study on the interaction between typical phthalic acid esters (PAEs) and human haemoglobin (hHb) by molecular docking. Environmental Toxicology and Pharmacology 53, pages 206-211.
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Angela L. Perez, Monty Liong, Kevin Plotkin, Keith P. Rickabaugh & Dennis J. Paustenbach. (2017) Health risk assessment of exposures to a high molecular weight plasticizer present in automobile interiors. Chemosphere 167, pages 541-550.
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Wolfgang Dekant & James Bridges. (2016) Assessment of reproductive and developmental effects of DINP, DnHP and DCHP using quantitative weight of evidence. Regulatory Toxicology and Pharmacology 81, pages 397-406.
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Zhenxing Chi, Jing Zhao, Hong You & Mingjing Wang. (2016) Study on the Mechanism of Interaction between Phthalate Acid Esters and Bovine Hemoglobin. Journal of Agricultural and Food Chemistry 64:30, pages 6035-6041.
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Manori J. Silva, Trevor W. Bontke, Antonia M. Calafat & Xiaoyun Ye. (2016) Identification of potential biomarkers of exposure to diundecyl phthalate. Environmental Research 148, pages 137-143.
Crossref
Mohammad Shah Alam & Masamichi Kurohmaru. (2016) Butylbenzyl phthalate induces spermatogenic cell apoptosis in prepubertal rats. Tissue and Cell 48:1, pages 35-42.
Crossref
Jonatan Axelsson, Lars Rylander, Anna Rignell-Hydbom, Bo A.G. Jönsson, Christian H. Lindh & Aleksander Giwercman. (2015) Phthalate exposure and reproductive parameters in young men from the general Swedish population. Environment International 85, pages 54-60.
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E. Dinant Kroese, Sieto Bosgra, Harrie E. Buist, Geertje Lewin, Sander C. van der Linden, Hai-yen Man, Aldert H. Piersma, Emiel Rorije, Sjors H.W. Schulpen, Michael Schwarz, Frederik Uibel, Barbara M.A. van Vugt-Lussenburg, Andre P.M. Wolterbeek & Bart van der Burg. (2015) Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context. Reproductive Toxicology 55, pages 11-19.
Crossref
Ling You, Yi-Xin Wang, Qiang Zeng, Min Li, Yue-Hui Huang, Yu Hu, Wen-Cheng Cao, Ai-Lin Liu & Wen-Qing Lu. (2015) Semen Phthalate Metabolites, Spermatozoa Apoptosis, and DNA Damage: A Cross-Sectional Study in China. Environmental Science & Technology 49:6, pages 3805-3812.
Crossref
Niraj Pant, G. Kumar, A. D. Upadhyay, D. K. Patel, Y. K. Gupta & P. K. Chaturvedi. (2014) Reproductive toxicity of lead, cadmium, and phthalate exposure in men. Environmental Science and Pollution Research 21:18, pages 11066-11074.
Crossref
Ying-Chu Lin, Kung-Kai Kuo, Kenly Wuputra, Shih-Han Lin, Chia-Chen Ku, Ya-Han Yang, Shin-Wei Wang, Sheng-Wen Wang, Deng-Chyang Wu, Chun-Chien Wu, Chee-Yin Chai, Cheng-Lung Lin, Chang-Shen Lin, Masayuki Kajitani, Hiroyuki Miyoshi, Yukio Nakamura, Shinichi Hashimoto, Kouji Matsushima, Chunyuan Jin, Shau-Ku Huang, Shigeo Saito & Kazunari Yokoyama. (2014) Bovine Induced Pluripotent Stem Cells Are More Resistant to Apoptosis than Testicular Cells in Response to Mono-(2-ethylhexyl) Phthalate. International Journal of Molecular Sciences 15:3, pages 5011-5031.
Crossref
Pergentino Balbuena, Jerry CampbellJr.Jr., Harvey J. ClewellIIIIII & Rebecca A. Clewell. (2013) Evaluation of a predictive in vitro Leydig cell assay for anti-androgenicity of phthalate esters in the rat. Toxicology in Vitro 27:6, pages 1711-1718.
Crossref
S. Magdouli, R. Daghrir, S.K. Brar, P. Drogui & R.D. Tyagi. (2013) Di 2-ethylhexylphtalate in the aquatic and terrestrial environment: A critical review. Journal of Environmental Management 127, pages 36-49.
Crossref
Xi Chen, Qizhi Qin, Wenjuan Zhang, Youjian Zhang, Hongyan Zheng, Chuanyao Liu, Yuqing Yang, Wei Xiong & Jing Yuan. (2013) Activation of the PI3K–AKT–mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation. Food and Chemical Toxicology 59, pages 325-333.
Crossref
Anne-Marie Saillenfait, Frédéric Gallissot, Jean-Philippe Sabaté & Aurélie Remy. (2013) Prenatal developmental toxicity studies on diundecyl and ditridecyl phthalates in Sprague-Dawley rats. Reproductive Toxicology 37, pages 49-55.
Crossref
Hermann Fromme, Ludwig Gruber, Ralph Schuster, Martin Schlummer, Mandy Kiranoglu, Gabriele Bolte & Wolfgang Völkel. (2013) Phthalate and di-(2-ethylhexyl) adipate (DEHA) intake by German infants based on the results of a duplicate diet study and biomonitoring data (INES 2). Food and Chemical Toxicology 53, pages 272-280.
Crossref
D.B. Martinez–Arguelles, M. McIntosh, C.V. Rohlicek, M. Culty, B.R. Zirkin & V. Papadopoulos. (2013) Maternal in utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate affects the blood pressure of adult male offspring. Toxicology and Applied Pharmacology 266:1, pages 95-100.
Crossref
Rebecca A. Clewell, Mark Sochaski, Kendra Edwards, Dianne M. Creasy, Gabrielle Willson & Melvin E. Andersen. (2013) Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats. Reproductive Toxicology 35, pages 56-69.
Crossref
Ranjan Banerjee, Wimal Pathmasiri, Rodney Snyder, Susan McRitchie & Susan Sumner. (2012) Metabolomics of brain and reproductive organs: characterizing the impact of gestational exposure to butylbenzyl phthalate on dams and resultant offspring. Metabolomics 8:6, pages 1012-1025.
Crossref
Xue-Feng Huang, Yan Li, Yi-Hua Gu, Miao Liu, Yan Xu, Yao Yuan, Fei Sun, Hui-Qin Zhang & Hui-Juan Shi. (2012) The Effects of Di-(2-ethylhexyl)-phthalate Exposure on Fertilization and Embryonic Development In Vitro and Testicular Genomic Mutation In Vivo. PLoS ONE 7:11, pages e50465.
Crossref
Du Yeon Bang, Minji Kyung, Min Ji Kim, Bu Young Jung, Myung Chan Cho, Seul Min Choi, Young Woo Kim, Seong Kwang Lim, Duck Soo Lim, A Jin Won, Seung Jun Kwack, Youngkwan Lee, Hyung Sik Kim & Byung Mu Lee. (2012) Human Risk Assessment of Endocrine‐Disrupting Chemicals Derived from Plastic Food Containers. Comprehensive Reviews in Food Science and Food Safety 11:5, pages 453-470.
Crossref
Benjamin E.G. Lucas, Christopher Fields, Neeraj Joshi & Marie-Claude Hofmann. (2012) Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia. Toxicology 299:1, pages 10-19.
Crossref
Xi Chen, Jianshu Wang, Qizhi Qin, Ying Jiang, Guangtao Yang, Kaimin Rao, Qian Wang, Wei Xiong & Jing Yuan. (2012) Mono-2-ethylhexyl phthalate induced loss of mitochondrial membrane potential and activation of Caspase3 in HepG2 cells. Environmental Toxicology and Pharmacology 33:3, pages 421-430.
Crossref
Pinar Erkekoglu, N. Dilara Zeybek, Belma Giray, Esin Asan & Filiz Hincal. (2011) The Effects of Di(2-Ethylhexyl)Phthalate Exposure and Selenium Nutrition on Sertoli Cell Vimentin Structure and Germ-Cell Apoptosis in Rat Testis. Archives of Environmental Contamination and Toxicology 62:3, pages 539-547.
Crossref
Anne-Marie Saillenfait, Alain-Claude Roudot, Frédéric Gallissot & Jean-Philippe Sabaté. (2011) Prenatal developmental toxicity studies on di-n-heptyl and di-n-octyl phthalates in Sprague-Dawley rats. Reproductive Toxicology 32:3, pages 268-276.
Crossref
Matthew T Martin, Thomas B. Knudsen, David M. Reif, Keith A. Houck, Richard S. Judson, Robert J. Kavlock & David J. Dix. (2011) Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening1. Biology of Reproduction 85:2, pages 327-339.
Crossref
H. Fromme, L. Gruber, E. Seckin, U. Raab, S. Zimmermann, M. Kiranoglu, M. Schlummer, U. Schwegler, S. Smolic & W. Völkel. (2011) Phthalates and their metabolites in breast milk — Results from the Bavarian Monitoring of Breast Milk (BAMBI). Environment International 37:4, pages 715-722.
Crossref

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