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Journal of Toxicology and Environmental Health, Part A
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Volume 73, 2009 - Issue 4
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Original Articles

Aging and Susceptibility to Toluene in Rats: A Pharmacokinetic, Biomarker, and Physiological Approach

Christopher J. Gordon National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USACorrespondence[email protected]
,
Reddy R. Gottipolu National Research Council
,
Elaina M. Kenyon National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
Ronald Thomas U.S. EPA NCBA/SEE Program
,
Mette C. Schladweiler National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
Cina M. Mack National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
Jonathan H. Shannahan Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
,
J. Grace Wallenborn Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
,
Abraham Nyska Tel Aviv University, Tel Aviv, Israel
,
Robert C. MacPhail National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
Judy E. Richards National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
Mike Devito National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
&
Urmila P. Kodavanti National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
 show all
Pages 301-318 | Received 02 May 2009, Accepted 01 Aug 2009, Published online: 14 Jan 2010

Citations (19)

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Sung Ha Ryu, Ji Won Kim, Yong Soon Kim, Seung-Ho Lee, Yong-Baik Cho, Hyo Keun Lee, Yoon Gyoon Kim, Woo-Sik Jeong & Kyu-Bong Kim. (2014) Negligible Pharmacokinetic Interaction of Red Ginseng and Antihypertensive Agent Amlodipine in Sprague-Dawley Rats. Journal of Toxicology and Environmental Health, Part A 77:22-24, pages 1372-1383.
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C. J. Gordon, A. F. Johnstone, C. Aydin, P. M. Phillips, R. C. MacPhail, U. P. Kodavanti, A. D. Ledbetter & K. A. Jarema. (2014) Episodic ozone exposure in adult and senescent Brown Norway rats: acute and delayed effect on heart rate, core temperature and motor activity. Inhalation Toxicology 26:7, pages 380-390.
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C. J. Gordon, K. A. Jarema, J. R. Lehmann, A. D. Ledbetter, M. C. Schladweiler, J. E. Schmid, W. O. Ward, U. P. Kodavanti, A. Nyska & R. C. MacPhail. (2013) Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function. Inhalation Toxicology 25:3, pages 141-159.
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Articles from other publishers (16)

Matthew C. Valdez, Danielle L. Freeborn, Padmaja Vulimiri, Joseph M. Valdez, Urmila P. Kodavanti & Prasada Rao S. Kodavanti. (2023) Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific. International Journal of Molecular Sciences 24:7, pages 6404.
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Prasada Rao S. Kodavanti, Matthew Valdez, Judy E. Richards, Datonye I. Agina-Obu, Pamela M. Phillips, Kimberly A. Jarema & Urmila P. Kodavanti. (2021) Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats. Toxicology and Applied Pharmacology 410, pages 115351.
Crossref
Wesley N Wayman & John J Woodward. (2017) Exposure to the Abused Inhalant Toluene Alters Medial Prefrontal Cortex Physiology. Neuropsychopharmacology 43:4, pages 912-924.
Crossref
Prasada Rao S. Kodavanti, Joyce E. Royland, Debra A. Moore-Smith, Jonathan Besas, Judy E. Richards, Tracey E. Beasley, Paul Evansky & Philip J. Bushnell. (2015) Acute and subchronic toxicity of inhaled toluene in male Long–Evans rats: Oxidative stress markers in brain. NeuroToxicology 51, pages 10-19.
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Christopher J. Gordon, Andrew F.M. Johnstone & Cenk Aydin. 2011. Comprehensive Physiology. Comprehensive Physiology 995 1016 .
Silvia L. Cruz, María Teresa Rivera-García & John J. Woodward. (2014) Review of Toluene Actions: Clinical Evidence, Animal Studies, and Molecular Targets. Journal of Drug and Alcohol Research 3, pages 1-8.
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Monique Chalansonnet, Nathalie Carabin, Stéphane Boucard, Frédéric Cosnier, Hervé Nunge & François Gagnaire. (2013) Study of the potential oxidative stress induced by six solvents in the rat brain. NeuroToxicology 35, pages 71-83.
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Nayeli Paez-Martinez, Jorge Aldrete-Audiffred, Alfredo Gallardo-Tenorio, Mario Castro-Garcia, Erika Estrada-Camarena & Carolina Lopez-Rubalcava. (2013) Participation of GABAA, GABAB receptors and neurosteroids in toluene-induced hypothermia: Evidence of concentration-dependent differences in the mechanism of action. European Journal of Pharmacology 698:1-3, pages 178-185.
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Ming-Huan Chan, Shiang-Sheng Chung, Astrid K. Stoker, Athina Markou & Hwei-Hsien Chen. (2012) Sarcosine attenuates toluene-induced motor incoordination, memory impairment, and hypothermia but not brain stimulation reward enhancement in mice. Toxicology and Applied Pharmacology 265:2, pages 158-165.
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Ming-Huan Chan, Chia-Chi Lee, Bih-Fen Lin, Chia-Yen Wu & Hwei-Hsien Chen. (2012) Metabotropic glutamate receptor 5 modulates behavioral and hypothermic responses to toluene in rats. Pharmacology Biochemistry and Behavior 103:2, pages 418-424.
Crossref
Joyce E. Royland, Prasada Rao S. Kodavanti, Judith E. Schmid & Robert C. MacPhail. (2012) Toluene Effects on Gene Expression in the Hippocampus of Young Adult, Middle-Age, and Senescent Brown Norway Rats. Toxicological Sciences 126:1, pages 193-212.
Crossref
R.C. MacPhail, J.D. Farmer & K.A. Jarema. (2012) Toluene effects on the motor activity of adolescent, young-adult, middle-age and senescent male Brown Norway rats. NeuroToxicology 33:1, pages 111-118.
Crossref
Prasada Rao S. Kodavanti, Joyce E. Royland, Judy E. Richards, Jonathan Besas & Robert C. MacPhail. (2011) Toluene effects on oxidative stress in brain regions of young-adult, middle-age, and senescent Brown Norway rats. Toxicology and Applied Pharmacology 256:3, pages 386-398.
Crossref
Christopher J. Gordon, Pamela J. Rowsey, Britton L. Bishop, William O. Ward & Robert C. MacPhail. (2011) Serum biomarkers of aging in the Brown Norway rat. Experimental Gerontology 46:11, pages 953-957.
Crossref
Hwei-Hsien Chen, Yi-Ruu Lin & Ming-Huan Chan. (2011) Toluene exposure during brain growth spurt and adolescence produces differential effects on N-methyl-d-aspartate receptor-mediated currents in rat hippocampus. Toxicology Letters 205:3, pages 336-340.
Crossref
Angelica Francesca Maris, Jeferson Luis Franco, Péricles Aruda Mitozo, Gislaine Paviani, Cristina Borowski, Rafael Trevisan, Marcela Uliano‐Silva, Marcelo Farina & Alcir Luiz Dafre. (2010) Gender Effects of Acute Malathion or Zinc Exposure on the Antioxidant Response of Rat Hippocampus and Cerebral Cortex. Basic & Clinical Pharmacology & Toxicology 107:6, pages 965-970.
Crossref

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