Advanced search
Publication Cover
Journal of Toxicology and Environmental Health, Part A
Current Issues
Volume 73, 2010 - Issue 5-6: Nanoparticles and Potential Human Health Implications: Past and Future Directions
Submit an article Journal homepage
378
Views
49
CrossRef citations to date
0
Altmetric
Original Articles

Pulmonary Inflammation After Intraperitoneal Administration of Ultrafine Titanium Dioxide (TiO2) At Rest or in Lungs Primed with Lipopolysaccharide

Changsuk Moon Departments of Physiology
,
Hyun-Jeong Park Departments of Physiology
,
Youn-Hee Choi Departments of Physiology
,
Eun-Mi Park Pharmacology, Division of Cell Biology, Ewha Medical Research Center, School of Medicine, Ewha Woman's University, Seoul, South Korea
,
Vincent Castranova Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
&
Jihee Lee Kang Departments of PhysiologyCorrespondence[email protected]
Pages 396-409 | Published online: 12 Feb 2010

Citations (49)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Sreejesh Sreedharan, Georgios Zouganelis, Samantha J Drake, Gyanendra Tripathi & Ali Kermanizadeh. (2023) Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B 26:1, pages 1-27.
Read now
Eleonore Fröhlich. (2015) Value of phagocyte function screening for immunotoxicity of nanoparticles in vivo. International Journal of Nanomedicine 10, pages 3761-3778.
Read now
Katherine M. Dunnick, Melissa A. Badding, Diane Schwegler-Berry, Jonathan M. Patete, Christopher Koenigsmann, Stanislaus S. Wong & Stephen S. Leonard. (2014) The Effect of Tungstate Nanoparticles on Reactive Oxygen Species and Cytotoxicity in Raw 264.7 Mouse Monocyte Macrophage Cells. Journal of Toxicology and Environmental Health, Part A 77:20, pages 1251-1268.
Read now
Sujatha Purushothaman, Azhwar Raghunath, Vasanth Dhakshinamoorthy, Lakshmikanthan Panneerselvam & Ekambaram Perumal. (2014) Acute exposure to titanium dioxide (TiO2) induces oxidative stress in zebrafish gill tissues. Toxicological & Environmental Chemistry 96:6, pages 890-905.
Read now
Eşref Demir, Durmuş Burgucu, Fatma Turna, Sezgin Aksakal & Bülent Kaya. (2013) Determination of TiO2, ZrO2, and Al2O3 Nanoparticles on Genotoxic Responses in Human Peripheral Blood Lymphocytes and Cultured Embyronic Kidney Cells. Journal of Toxicology and Environmental Health, Part A 76:16, pages 990-1002.
Read now
Rona M. Silva, Christel TeeSy, Lisa Franzi, Alex Weir, Paul Westerhoff, James E. Evans & Kent E. Pinkerton. (2013) Biological Response to Nano-Scale Titanium Dioxide (TiO2): Role of Particle Dose, Shape, and Retention. Journal of Toxicology and Environmental Health, Part A 76:16, pages 953-972.
Read now
Maurizio Gualtieri, Tonje Skuland, Tore-Geir Iversen, Marit Låg, Per Schwarze, Dagmar Bilaničová, Giulio Pojana & Magne Refsnes. (2012) Importance of agglomeration state and exposure conditions for uptake and pro-inflammatory responses to amorphous silica nanoparticles in bronchial epithelial cells. Nanotoxicology 6:7, pages 700-712.
Read now

Articles from other publishers (42)

Ji-Hye Ha, Ba-Wool Lee, Da-Hye Yi, Se-Jin Lee, Woong-Il Kim, So-Won Pak, Hyeon-Young Kim, Sung-Hwan Kim, In-Sik Shin, Jong-Choon Kim & In-Chul Lee. (2024) Particulate matter-mediated oxidative stress induces airway inflammation and pulmonary dysfunction through TXNIP/NF-κB and modulation of the SIRT1-mediated p53 and TGF-β/Smad3 pathways in mice. Food and Chemical Toxicology 183, pages 114201.
Crossref
Angel Insua, Pablo Galindo‐Moreno, Richard J. Miron, Hom‐Lay Wang & Alberto Monje. (2023) Emerging factors affecting peri‐implant bone metabolism. Periodontology 2000.
Crossref
Congcong Li & Meng Tang. (2023) The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity. Journal of Applied Toxicology.
Crossref
Mattias Pettersson, Sanna Almlin, Georgios E. Romanos & Anders Johansson. (2022) Ti Ions Induce IL-1β Release by Activation of the NLRP3 Inflammasome in a Human Macrophage Cell Line. Inflammation 45:5, pages 2027-2037.
Crossref
Dinesh Kumar Chellappan, Parteek Prasher, Vilashini Saravanan, Vanessa See Vern Yee, Wendy Chai Wen Chi, Jia Wei Wong, Joon Kang Wong, Jing Tong Wong, Wai Wan, Jestin Chellian, Nagashekhara Molugulu, Sakthivel Lakshmana Prabu, Rania Ibrahim, Thiviya Darmarajan, Mayuren Candasamy, Pankaj Kumar Singh, Vijay Mishra, Madhur D. Shastri, Flavia C. Zacconi, Amlan Chakraborty, Meenu Mehta, Piyush Kumar Gupta, Harish Dureja, Monica Gulati, Sachin Kumar Singh, Gaurav Gupta, Niraj Kumar Jha, Brian Gregory George Oliver & Kamal Dua. (2022) Protein and peptide delivery to lungs by using advanced targeted drug delivery. Chemico-Biological Interactions 351, pages 109706.
Crossref
Nourhan Kamal Mohamed, Mahmoud Elsabahy, Karen L. Wooley & Noura G. Eissa. 2022. Immunomodulatory Effects of Nanomaterials. Immunomodulatory Effects of Nanomaterials 65 114 .
Ravinder Verma, Deepika Purohit, Pawan Jalwal, Deepak Kaushik & Parijat Pandey. 2022. Immunomodulators and Human Health. Immunomodulators and Human Health 187 207 .
Frédérick Barreau, Céline Tisseyre, Sandrine Ménard, Audrey Ferrand & Marie Carriere. (2021) Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer. Particle and Fibre Toxicology 18:1.
Crossref
Mariana Garcés, Lourdes Cáceres, Diego Chiappetta, Natalia Magnani & Pablo Evelson. (2021) Current understanding of nanoparticle toxicity mechanisms and interactions with biological systems. New Journal of Chemistry 45:32, pages 14328-14344.
Crossref
Wided Najahi-Missaoui, Robert D. Arnold & Brian S. Cummings. (2020) Safe Nanoparticles: Are We There Yet?. International Journal of Molecular Sciences 22:1, pages 385.
Crossref
Waqas Nawaz, Shijie Xu, Yanlei Li, Bilian Huang, Xilin Wu & Zhiwei Wu. (2020) Nanotechnology and immunoengineering: How nanotechnology can boost CAR-T therapy. Acta Biomaterialia 109, pages 21-36.
Crossref
Loutfy H. Madkour. 2020. Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms. Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms 421 447 .
Vinay Kumar, Sivarama Krishna Lakkaboyana, Neha Sharma, Subhrangsu Sunder Maitra & Marlia Mohd Hanafiah. 2020. Intelligent Nanomaterials for Drug Delivery Applications. Intelligent Nanomaterials for Drug Delivery Applications 163 178 .
Zukun Yang, Liping Han, Yu Guo, Lu Jia, Cheng Yin & Yang Xia. 2020. Nanotechnology in Regenerative Medicine and Drug Delivery Therapy. Nanotechnology in Regenerative Medicine and Drug Delivery Therapy 91 189 .
Loutfy H. MadkourLoutfy H. Madkour. 2020. Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses. Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses 285 328 .
Yi-Chun Chen, Chia-Hua Lin, Shih-Chun Candice Lung, Ku-Fan Chen, Wen-Cheng Vincent Wang, Cheng-Tai Chou & Chia-Hsiang Lai. (2019) Environmental concentration of spray paint particulate matters causes pulmonary dysfunction in human normal bronchial epithelial BEAS-2B cell. Process Safety and Environmental Protection 126, pages 250-258.
Crossref
Wided N. Missaoui, Robert D. Arnold & Brian S. Cummings. (2018) Toxicological status of nanoparticles: What we know and what we don't know. Chemico-Biological Interactions 295, pages 1-12.
Crossref
Paul Høl, Einar Kristoffersen, Nils Gjerdet & Amanda Pellowe. (2018) Novel Nanoparticulate and Ionic Titanium Antigens for Hypersensitivity Testing. International Journal of Molecular Sciences 19:4, pages 1101.
Crossref
Tianshu Wu & Meng Tang. (2018) Review of the effects of manufactured nanoparticles on mammalian target organs. Journal of Applied Toxicology 38:1, pages 25-40.
Crossref
Qi Xiong, Qin Ru, Lin Chen, Xiang Tian & Chaoying Li. (2017) Mitochondrial dysfunction and inflammatory response in the cytotoxicity of NR8383 macrophages induced by fine particulate matter. Environmental Toxicology and Pharmacology 55, pages 1-7.
Crossref
M. Pettersson, P. Kelk, G. N. Belibasakis, D. Bylund, M. Molin Thorén & A. Johansson. (2017) Titanium ions form particles that activate and execute interleukin-1β release from lipopolysaccharide-primed macrophages. Journal of Periodontal Research 52:1, pages 21-32.
Crossref
Rui Chen, Bin Hu, Ying Liu, Jianxun Xu, Guosheng Yang, Diandou Xu & Chunying Chen. (2016) Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:12, pages 2844-2855.
Crossref
Paola Pedata, Claudia Petrarca, Elpidio Maria Garzillo & Mario Di Gioacchino. (2016) Immunotoxicological impact of occupational and environmental nanoparticles exposure: The influence of physical, chemical, and combined characteristics of the particles. International Journal of Immunopathology and Pharmacology 29:3, pages 343-353.
Crossref
Muhammad Shakeel, Farhat Jabeen, Samina Shabbir, Muhammad Saleem Asghar, Muhammad Saleem Khan & Abdul Shakoor Chaudhry. (2015) Toxicity of Nano-Titanium Dioxide (TiO2-NP) Through Various Routes of Exposure: a Review. Biological Trace Element Research 172:1, pages 1-36.
Crossref
Arka Mukhopadhyay & Hirak K. Patra. 2016. Advanced Materials Interfaces. Advanced Materials Interfaces 405 425 .
Sourabh Shukla & Nicole F Steinmetz. (2016) Emerging nanotechnologies for cancer immunotherapy. Experimental Biology and Medicine 241:10, pages 1116-1126.
Crossref
Intissar Grissa, Jaber Elghoul, Lobna Ezzi, Sana Chakroun, Emna Kerkeni, Mohsen Hassine, Lassaad El Mir, Meriem Mehdi, Hassen Ben Cheikh & Zohra Haouas. (2015) Anemia and genotoxicity induced by sub-chronic intragastric treatment of rats with titanium dioxide nanoparticles. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 794, pages 25-31.
Crossref
Kyeong-Nam Yu, Jae Hyuck Sung, Somin Lee, Ji-Eun Kim, Sanghwa Kim, Won-Young Cho, Ah Young Lee, Soo Jin Park, Joohyun Lim, Changhoon Park, Chanhee Chae, Jin Kyu Lee, Jinkyu Lee, Jun-Sung Kim & Myung-Haing Cho. (2015) Inhalation of titanium dioxide induces endoplasmic reticulum stress-mediated autophagy and inflammation in mice. Food and Chemical Toxicology 85, pages 106-113.
Crossref
Baoyong Sha, Wei Gao, Xingye Cui, Lin Wang & Feng Xu. (2015) The potential health challenges of TiO 2 nanomaterials . Journal of Applied Toxicology 35:10, pages 1086-1101.
Crossref
Naima Rihane Ben Younes, Salem Amara, Imen Mrad, Imen Ben-Slama, Mustapha Jeljeli, Karim Omri, Jaber El Ghoul, Lassaad El Mir, Khemais Ben Rhouma, Hafedh Abdelmelek & Mohsen Sakly. (2015) Subacute toxicity of titanium dioxide (TiO2) nanoparticles in male rats: emotional behavior and pathophysiological examination. Environmental Science and Pollution Research 22:11, pages 8728-8737.
Crossref
Masanori HorieKeiko NishioHaruhisa KatoShigehisa EndohKatsuhide FujitaAyako NakamuraArisa MiyauchiShinichi KinugasaYoshihisa HagiharaYasukazu YoshidaHitoshi Iwahashi. (2015) The Expression of Inflammatory Cytokine and Heme Oxygenase-1 Genes in THP-1 Cells Exposed to Metal Oxide Nanoparticles. Journal of Nano Research 30, pages 116-127.
Crossref
Massimiliano G. Bianchi, Manfredi Allegri, Anna L. Costa, Magda Blosi, Davide Gardini, Camilla Del Pivo, Adriele Prina-Mello, Luisana Di Cristo, Ovidio Bussolati & Enrico Bergamaschi. (2015) Titanium dioxide nanoparticles enhance macrophage activation by LPS through a TLR4-dependent intracellular pathway. Toxicology Research 4:2, pages 385-398.
Crossref
Ruchi Roy, Dinesh Kumar, Akanksha Sharma, Parul Gupta, Bhushan P. Chaudhari, Anurag Tripathi, Mukul Das & Premendra D. Dwivedi. (2014) ZnO nanoparticles induced adjuvant effect via toll-like receptors and Src signaling in Balb/c mice. Toxicology Letters 230:3, pages 421-433.
Crossref
Hongbo Shi, Ruth Magaye, Vincent Castranova & Jinshun Zhao. (2013) Titanium dioxide nanoparticles: a review of current toxicological data. Particle and Fibre Toxicology 10:1.
Crossref
Amruta Manke, Liying Wang & Yon Rojanasakul. (2013) Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity. BioMed Research International 2013, pages 1-15.
Crossref
Abderrahim Nemmar, Jørn A. Holme, Irma Rosas, Per E. Schwarze & Ernesto Alfaro-Moreno. (2013) Recent Advances in Particulate Matter and Nanoparticle Toxicology: A Review of the In Vivo and In Vitro Studies . BioMed Research International 2013, pages 1-22.
Crossref
Mahmoud Elsabahy & Karen L. Wooley. (2013) Cytokines as biomarkers of nanoparticle immunotoxicity. Chemical Society Reviews 42:12, pages 5552.
Crossref
Eric Y Chen, Maria Garnica, Yung-Chen Wang, Alexander J Mintz, Chi-Shuo Chen & Wei-Chun Chin. (2012) A mixture of anatase and rutile TiO2 nanoparticles induces histamine secretion in mast cells. Particle and Fibre Toxicology 9:1.
Crossref
Qingqing Sun, Danlin Tan, Qiuping Zhou, Xiaorun Liu, Zhe Cheng, Gan Liu, Min Zhu, Xuezi Sang, Suxin Gui, Jie Cheng, Renping Hu, Meng Tang & Fashui Hong. (2012) Oxidative damage of lung and its protective mechanism in mice caused by long-term exposure to titanium dioxide nanoparticles. Journal of Biomedical Materials Research Part A 100A:10, pages 2554-2562.
Crossref
Ivo Iavicoli, Veruscka Leso & Antonio Bergamaschi. (2012) Toxicological Effects of Titanium Dioxide Nanoparticles: A Review of In Vivo Studies . Journal of Nanomaterials 2012, pages 1-36.
Crossref
Se Eun Byeon, Young-Su Yi, Jueun Oh, Byong Chul Yoo, Sungyoul Hong & Jae Youl Cho. (2012) The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation 2012, pages 1-18.
Crossref
Stephan Hackenberg, Gudrun Friehs, Michael Kessler, Katrin Froelich, Christian Ginzkey, Christian Koehler, Agmal Scherzed, Marc Burghartz & Norbert Kleinsasser. (2010) Nanosized titanium dioxide particles do not induce DNA damage in human peripheral blood lymphocytes. Environmental and Molecular Mutagenesis 52:4, pages 264-268.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.