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Journal of Toxicology and Environmental Health, Part A
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Volume 73, 2010 - Issue 21-22: Current Issues in Toxicology in Korea, 4th Toxicology Symposium
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Original Articles

Comparative Nephrotoxicitiy Induced by Melamine, Cyanuric Acid, or a Mixture of Both Chemicals in Either Sprague-Dawley Rats or Renal Cell Lines

Lan Choi Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Min Young Kwak Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Eun Hwa Kwak Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Dong Hyun Kim Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Eun Young Han Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Taehyun Roh Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Jung Yun Bae Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Il Young Ahn Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Jea Yeon Jung Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Mi Jung Kwon Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Dong Eun Jang National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea
,
Seong Kwang Lim National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea
,
Seung Jun Kwack National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea
,
Soon Young Han Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Busan, Korea
,
Tae Seok Kang Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Busan, Korea
,
Seung Hee Kim Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, Korea
,
Hyung Sik Kim Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Busan, Korea
&
Byung Mu Lee Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, KoreaCorrespondence[email protected]
 show all
Pages 1407-1419 | Published online: 13 Oct 2010

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Linda S. Von Tungeln, Cristina C. Jacob, Greg R. Olson, Gonçalo Gamboa da Costa & Frederick A. Beland. (2021) Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid. Journal of Environmental Science and Health, Part C 39:3, pages 340-355.
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Ghee Hwan Kim, Mi Jeong Kang, Keumhan Noh, Do Gyeong Oh, Wonku Kang, Hye Gwang Jeong, Kwang Youl Lee, Hangun Kim, Hyung Sik Kim & Tae Cheon Jeong. (2014) Nephrotoxic Potential and Toxicokinetics of Melamine Combined with Cyanuric Acid in Rats. Journal of Toxicology and Environmental Health, Part A 77:22-24, pages 1346-1358.
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Seung Jun Kwack, Seon-Gil Do, Young Woo Kim, Yeon-Joo Kim, Hyo-Min Gwak, Hyun Jong Park, Taehyun Roh, Min Kyung Shin, Seong Kwang Lim, Hyung Sik Kim & Byung-Mu Lee. (2014) The No-Observed-Adverse-Effect Level (NOAEL) of Baby Aloe Powder (BAP) for Nutraceutical Application Based Upon Toxicological Evaluation. Journal of Toxicology and Environmental Health, Part A 77:22-24, pages 1319-1331.
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Nicole Pacini, Marino Prearo, Maria Cesarina Abete, Paola Brizio, Ambrosius Josef Martin Dörr, Renate Reimschuessel, Wendy Andersen, Laura Gasco, Marzia Righetti & Antonia Concetta Elia. (2013) Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid. Journal of Toxicology and Environmental Health, Part A 76:8, pages 491-508.
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C.Y. CHU & C.C. WANG. (2013) Toxicity of Melamine: The Public Health Concern. Journal of Environmental Science and Health, Part C 31:4, pages 342-386.
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Articles from other publishers (43)

Shaojie Liu, Ruihua Dong, Yifei Wang, Zhiping Yang, Gengsheng He & Bo Chen. (2023) Twenty-four-hour temporal trend of melamine and its derivatives in urine in association with meal consumption: a panel study in Shanghai, China. Environmental Science and Pollution Research 30:57, pages 120225-120235.
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Yumeng Shi, Shucong Chen, Ke Xu, Leicheng Zhao, Yarui Liu, Qiang Zou, Henglin Zhang, Hongkai Zhu, Tao Zhang & Hongwen Sun. (2023) Exposure to nitrogenous based flame retardants in Chinese population: Evidence from a national-scale study. Journal of Hazardous Materials 445, pages 130653.
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Yumeng Shi, Shucong Chen, Mengqi Yan, Zhipeng Cheng, Leicheng Zhao, Yarui Liu, Bo Zhang, Hongkai Zhu, Tao Zhang & Kurunthachalam Kannan. (2023) Elevated levels of biomarkers of oxidative stress and renal injury linked to nitrogenous flame retardants exposure in e-waste dismantling site: A case study in China. Chemosphere 314, pages 137747.
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Wei Sun, Xiao Chen, Yazi Mei, Xiaoliang Li, Yang Yang & Lei An. (2022) Co-exposure of melamine and cyanuric acid as a risk factor for oxidative stress and energy metabolism: Adverse effects on hippocampal neuronal and synaptic function induced by excessive ROS production. Ecotoxicology and Environmental Safety 247, pages 114230.
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ShaoJie Liu, Qi Zhao, FeiFei Huang, QiFan Yang, YiFei Wang, HangWei Wang, YongYun Sun, YuJia Yan, GengSheng He, GenMing Zhao, RuiHua Dong & Bo Chen. (2022) Exposure to melamine and its derivatives in Chinese adults: The cumulative risk assessment and the effect on routine blood parameters. Ecotoxicology and Environmental Safety 241, pages 113714.
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Wei Sun, Yang Yang, Yazi Mei, Yuanhua Wu, Xiao Chen & Lei An. (2022) Prenatal cyanuric acid exposure depresses hippocampal synaptic plasticity and induces spatial learning and memory deficits. Toxicology Letters 354, pages 24-32.
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Ehsan H. Abu-Zeid, Doaaa M. Abdel Fattah, Ahmed H. Arisha, Tamer A. Ismail, Dina M. Alsadek, Mohamed M.M. Metwally, Ahmed A. El-Sayed & Amany T. Khalil. (2021) Protective prospects of eco-friendly synthesized selenium nanoparticles using Moringa oleifera or Moringa oleifera leaf extract against melamine induced nephrotoxicity in male rats. Ecotoxicology and Environmental Safety 221, pages 112424.
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Yasmina M. Abd-Elhakim, Wafaa A.M. Mohamed, Khlood M. El.Bohi, Haytham A. Ali, Fagr A. Mahmoud & Taghred M. Saber. (2021) Prevention of melamine-induced hepatorenal impairment by an ethanolic extract of Moringa oleifera: Changes in KIM-1, TIMP-1, oxidative stress, apoptosis, and inflammation-related genes. Gene 764, pages 145083.
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Olwenn Martin, Martin Scholze, Sibylle Ermler, Joanne McPhie, Stephanie K. Bopp, Aude Kienzler, Nikolaos Parissis & Andreas Kortenkamp. (2021) Ten years of research on synergisms and antagonisms in chemical mixtures: A systematic review and quantitative reappraisal of mixture studies. Environment International 146, pages 106206.
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Melissa Melough, Deborah Foster, Amanda M. Fretts & Sheela Sathyanarayana. (2020) Dietary Sources of Melamine Exposure among US Children and Adults in the National Health and Nutrition Examination Survey 2003–2004. Nutrients 12:12, pages 3844.
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Abdullah MELEKOĞLU, Hüsamettin EKİCİ, Esra ARAT & Siyami KARAHAN. (2020) Evaluation of melamine and cyanuric acid cytotoxicity: an in vitro study on L929 fibroblasts and CHO cell line. Ankara Üniversitesi Veteriner Fakültesi Dergisi 67:4, pages 399-406.
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Jianqiu Guo, Chunhua Wu, Jiming Zhang, Xiuli Chang, Yubin Zhang, Yang Cao & Zhijun Zhou. (2020) Associations of melamine and cyanuric acid exposure with markers of kidney function in adults: Results from NHANES 2003–2004. Environment International 141, pages 105815.
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Hongkai Zhu & Kurunthachalam Kannan. (2020) Determination of melamine and its derivatives in textiles and infant clothing purchased in the United States. Science of The Total Environment 710, pages 136396.
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Hongkai Zhu & Kurunthachalam Kannan. (2020) Occurrence and distribution of melamine and its derivatives in surface water, drinking water, precipitation, wastewater, and swimming pool water. Environmental Pollution 258, pages 113743.
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XinLi Shi, RuiHua Dong, JingSi Chen, Yaqun Yuan, Qilai Long, Jianming Guo, Shuguang Li & Bo Chen. (2020) An assessment of melamine exposure in Shanghai adults and its association with food consumption. Environment International 135, pages 105363.
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Hongkai Zhu & Kurunthachalam Kannan. (2019) Melamine and cyanuric acid in foodstuffs from the United States and their implications for human exposure. Environment International 130, pages 104950.
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Hidayet Tutun. (2019) Anti-Proliferative Effect of Melamine on Human Colon Adenocarcinoma Cells. Kocatepe Veterinary Journal, pages 1-1.
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Hongkai Zhu & Kurunthachalam Kannan. (2019) Occurrence of Melamine and Its Derivatives in Breast Milk from the United States and Its Implications for Exposure in Infants. Environmental Science & Technology 53:13, pages 7859-7865.
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Hongkai Zhu & Kurunthachalam Kannan. (2019) Inter-day and inter-individual variability in urinary concentrations of melamine and cyanuric acid. Environment International 123, pages 375-381.
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Feifei Wang, Qiaojuan Liu, Lizi Jin, Shan Hu, Renfei Luo, Mengke Han, Yonggong Zhai, Weidong Wang & Chunling Li. (2018) Combination exposure of melamine and cyanuric acid is associated with polyuria and activation of NLRP3 inflammasome in rats. American Journal of Physiology-Renal Physiology 315:2, pages F199-F210.
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Camila S. Silva, Ching-Wei Chang, Denita Williams, Patricia Porter-Gill, Gonçalo Gamboa da Costa & Luísa Camacho. (2016) Effects of a 28-day dietary co-exposure to melamine and cyanuric acid on the levels of serum microRNAs in male and female Fisher 344 rats. Food and Chemical Toxicology 98, pages 11-16.
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In-Chul Lee, Je-Won Ko, Sung-Hyeuk Park, In-Sik Shin, Changjong Moon, Sung-Ho Kim, Yun-Bae Kim & Jong-Choon Kim. (2016) Melamine and cyanuric acid co-exposure causes renal dysfunction and structural damage via MAPKs and mitochondrial signaling. Food and Chemical Toxicology 96, pages 254-262.
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Jiarui Sun, Xinchen Zhang, Yinan Cao, Qiling Zhao, Endong Bao & Yingjun Lv. (2016) Ovarian Toxicity in Female Rats after Oral Administration of Melamine or Melamine and Cyanuric Acid. PLOS ONE 11:2, pages e0149063.
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Ming-Tsang Wu, Chia-Fang Wu & Bai-Hsiun Chen. (2015) Behavioral Intervention and Decreased Daily Melamine Exposure from Melamine Tableware. Environmental Science & Technology 49:16, pages 9964-9970.
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Dandan Chen, Qiong Wu, Jun Wang, Qi Wang & Heng Qiao. (2015) Spectroscopic analyses and studies on respective interaction of cyanuric acid and uric acid with bovine serum albumin and melamine. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 135, pages 511-520.
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Ji Yeon Son, Yoon Jong Kang, Kyeong Seok Kim, Tae Hyung Kim, Sung Kwang Lim, Hyun Jung Lim, Tae Cheon Jeong, Dal Woong Choi, Kyu Hyuck Chung, Byung Mu Lee & Hyung Sik Kim. (2014) Evaluation of Renal Toxicity by Combination Exposure to Melamine and Cyanuric Acid in Male Sprague-Dawley Rats. Toxicological Research 30:2, pages 99-107.
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Yng-Tay Chen, Bang-Ping Jiann, Chieh-Hao Wu, Jhaol-Huei Wu, Shih-Chieh Chang, Maw-Sheng Chien, Shih-Ling Hsuan, Yi-Lo Lin, Ter-Hsin Chen, Fuu-Jen Tsai & Jiunn-Wang Liao. (2014) Kidney stone distribution caused by melamine and cyanuric acid in rats. Clinica Chimica Acta 430, pages 96-103.
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Jean Lou Dorne, Daniel R. Doerge, Marc Vandenbroeck, Johanna Fink-Gremmels, Wim Mennes, Helle K. Knutsen, Francesco Vernazza, Laurence Castle, Lutz Edler & Diane Benford. (2013) Recent advances in the risk assessment of melamine and cyanuric acid in animal feed. Toxicology and Applied Pharmacology 270:3, pages 218-229.
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Richard J. Early, Hong Yu, Xueyan Peter Mu, Haiyan Xu, Lei Guo, Qingxue Kong, Junma Zhou, Bruce He, Xiuying Yang, Hailiang Huang, Edward Hu & Ying Jiang. (2012) Repeat oral dose toxicity studies of melamine in rats and monkeys. Archives of Toxicology 87:3, pages 517-527.
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