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Original Articles

Evaluation of Okadaic Acid-Induced Genotoxicity in Human Cells Using the Micronucleus Test and γH2AX Analysis

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Pages 980-992 | Published online: 27 Jun 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Fátima Brandão, Carla Costa, Maria João Bessa, Vanessa Valdiglesias, Bryan Hellack, Andrea Haase, Sónia Fraga & João Paulo Teixeira. (2023) Multiparametric in vitro genotoxicity assessment of different variants of amorphous silica nanomaterials in rat alveolar epithelial cells. Nanotoxicology 17:6-7, pages 511-528.
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Diego Figueroa, Ailen Signore, Oscar Araneda, Héctor R. Contreras, Miguel Concha & Carlos García. (2020) Toxicity and differential oxidative stress effects on zebrafish larvae following exposure to toxins from the okadaic acid group. Journal of Toxicology and Environmental Health, Part A 83:15-16, pages 573-588.
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Vanessa Valdiglesias, Juan Fernández-Tajes, Carla Costa, Josefina Méndez, Eduardo Pásaro & Blanca Laffon. (2012) Alterations in Metabolism-Related Genes Induced in SHSY5Y Cells by Okadaic Acid Exposure. Journal of Toxicology and Environmental Health, Part A 75:13-15, pages 844-856.
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Vanessa Valdiglesias, Gözde Kiliç, Carla Costa, Óscar Amor-Carro, Luis Mariñas-Pardo, David Ramos-Barbón, Josefina Méndez, Eduardo Pásaro & Blanca Laffon. (2012) In Vivo Genotoxicity Assessment in Rats Exposed to Prestige-Like Oil by Inhalation. Journal of Toxicology and Environmental Health, Part A 75:13-15, pages 756-764.
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Mohamed H. Mona, Gihan M. El-Khodary, Khaled Y. Abdel-Halim, Nahla E. Omran, Karolin K. Abd El-Aziz & Salwa A. El-Saidy. (2021) Histopathological alterations induced by marine environmental pollutants on the bivalve Cerastoderma glaucum (Bruguière 1789) from Temsah Lake, Suez Canal, Egypt. Environmental Science and Pollution Research 29:7, pages 9971-9989.
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Blanca Laffon, María Sánchez-Flores, Natalia Fernández-Bertólez, Eduardo Pásaro & Vanessa Valdiglesias. (2021) Applicability of flow cytometry γH2AX assay in population studies: suitability of fresh and frozen whole blood samples. Archives of Toxicology 95:5, pages 1843-1851.
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Ludovic Le Hegarat, Alain-Claude Roudot & Valérie Fessard. (2020) Benchmark dose analyses of γH2AX and pH3 endpoints for quantitative comparison of in vitro genotoxicity potential of lipophilic phycotoxins. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 852, pages 503169.
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Angela Marina Montalbano, Giusy Daniela Albano, Giulia Anzalone, Monica Moscato, Rosalia Gagliardo, Caterina Di Sano, Anna Bonanno, Silvia Ruggieri, Fabio Cibella & Mirella Profita. (2020) Cytotoxic and genotoxic effects of the flame retardants (PBDE-47, PBDE-99 and PBDE-209) in human bronchial epithelial cells. Chemosphere 245, pages 125600.
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Fátima Brandão, Natalia Fernández-Bertólez, Fernanda Rosário, Maria João Bessa, Sónia Fraga, Eduardo Pásaro, João Paulo Teixeira, Blanca Laffon, Vanessa Valdiglesias & Carla Costa. (2020) Genotoxicity of TiO2 Nanoparticles in Four Different Human Cell Lines (A549, HEPG2, A172 and SH-SY5Y). Nanomaterials 10:3, pages 412.
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Ling-ling Fu, Xiao-yu Zhao, Lin-dan Ji & Jin Xu. (2019) Okadaic acid (OA): Toxicity, detection and detoxification. Toxicon 160, pages 1-7.
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Elizabeth A Ainsbury, Daniel Samaga, Sara Della Monaca, Maurizio Marrale, Celine Bassinet, Christopher I Burbidge, Virgilio Correcher, Michael Discher, Jon Eakins, Paola Fattibene, İnci Güçlü, Manuel Higueras, Eva Lund, Nadica Maltar-Strmečki, Stephen McKeever, Christopher L Rääf, Sergey Sholom, Ivan Veronese, Albrecht Wieser, Clemens Woda & Francois Trompier. (2018) UNCERTAINTY ON RADIATION DOSES ESTIMATED BY BIOLOGICAL AND RETROSPECTIVE PHYSICAL METHODS. Radiation Protection Dosimetry 178:4, pages 382-404.
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Blanca Laffon, Natalia Fernández-Bertólez, Carla Costa, Fátima Brandão, João Paulo Teixeira, Eduardo Pásaro & Vanessa Valdiglesias. 2018. Cellular and Molecular Toxicology of Nanoparticles. Cellular and Molecular Toxicology of Nanoparticles 199 213 .
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Blanca Laffon, Natalia Fernández-Bertólez, Carla Costa, Eduardo Pásaro & Vanessa Valdiglesias. (2017) Comparative study of human neuronal and glial cell sensitivity for in vitro neurogenotoxicity testing. Food and Chemical Toxicology 102, pages 120-128.
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María Sánchez-Flores, Eduardo Pásaro, Stefano Bonassi, Blanca Laffon & Vanessa Valdiglesias. (2015) γH2AX Assay as DNA Damage Biomarker for Human Population Studies: Defining Experimental Conditions. Toxicological Sciences 144:2, pages 406-413.
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Zhong-Ji Qian, Kyong-Hwa Kang & BoMi Ryu. 2015. Handbook of Marine Microalgae. Handbook of Marine Microalgae 527 537 .
Aníbal Martínez, Alejandro Garrido-Maestu, Begoña Ben-Gigirey, María José Chapela, Virginia González, Juan M. Vieites & Ana G. Cabado. 2015. Hb25_Springer Handbook of Marine Biotechnology. Hb25_Springer Handbook of Marine Biotechnology 869 904 .
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Valérie Fessard. 2014. Toxins and Biologically Active Compounds from Microalgae, Volume 2. Toxins and Biologically Active Compounds from Microalgae, Volume 2 253 282 .
Anke Ehlers, Anja These, Stefanie Hessel, Angelika Preiss-Weigert & Alfonso Lampen. (2014) Active elimination of the marine biotoxin okadaic acid by P-glycoprotein through an in vitro gastrointestinal barrier. Toxicology Letters 225:2, pages 311-317.
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Blanca Laffon, Francisco Aguilera, Julia Ríos-Vázquez, Vanessa Valdiglesias & Eduardo Pásaro. (2014) Follow-up study of genotoxic effects in individuals exposed to oil from the tanker Prestige, seven years after the accident. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 760, pages 10-16.
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Rex Munday & John Reeve. (2013) Risk Assessment of Shellfish Toxins. Toxins 5:11, pages 2109-2137.
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Vanessa Valdiglesias, María Prego-Faraldo, Eduardo Pásaro, Josefina Méndez & Blanca Laffon. (2013) Okadaic Acid: More than a Diarrheic Toxin. Marine Drugs 11:11, pages 4328-4349.
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María Prego-Faraldo, Vanessa Valdiglesias, Josefina Méndez & José Eirín-López. (2013) Okadaic Acid Meet and Greet: An Insight into Detection Methods, Response Strategies and Genotoxic Effects in Marine Invertebrates. Marine Drugs 11:8, pages 2829-2845.
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Vanessa Valdiglesias, Juan Fernández-Tajes, Josefina Méndez, Eduardo Pásaro & Blanca Laffon. (2013) The marine toxin okadaic acid induces alterations in the expression level of cancer-related genes in human neuronal cells. Ecotoxicology and Environmental Safety 92, pages 303-311.
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Jill Opsahl, Sonja Ljostveit, Therese Solstad, Kristin Risa, Peter Roepstorff & Kari Fladmark. (2013) Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid. Marine Drugs 11:6, pages 1763-1782.
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Vanessa Valdiglesias, Carla Costa, Gözde Kiliç, Solange Costa, Eduardo Pásaro, Blanca Laffon & João Paulo Teixeira. (2013) Neuronal cytotoxicity and genotoxicity induced by zinc oxide nanoparticles. Environment International 55, pages 92-100.
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Vanessa Valdiglesias, Juan Fernández-Tajes, Eduardo Pásaro, Josefina Méndez & Blanca Laffon. (2012) Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization. BMC Genomics 13:1.
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Julia García-Lestón, Joana Roma-Torres, Maria Vilares, Rui Pinto, João Prista, João Paulo Teixeira, Olga Mayan, João Conde, Marta Pingarilho, Jorge Francisco Gaspar, Eduardo Pásaro, Josefina Méndez & Blanca Laffon. (2012) Genotoxic effects of occupational exposure to lead and influence of polymorphisms in genes involved in lead toxicokinetics and in DNA repair. Environment International 43, pages 29-36.
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Rodrigo González-Romero, Ciro Rivera-Casas, Juan Fernández-Tajes, Juan Ausió, Josefina Méndez & José M. Eirín-López. (2012) Chromatin specialization in bivalve molluscs: A leap forward for the evaluation of Okadaic Acid genotoxicity in the marine environment. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 155:2, pages 175-181.
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