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Journal of Toxicology and Environmental Health, Part A
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Volume 74, 2011 - Issue 21: Bioactivity of Oil Dispersant in the Deepwater Horizon Clean-up Operation
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Original Articles

Acute Effects of COREXIT EC9500A on Cardiovascular Functions in Rats

Kristine Krajnak Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USACorrespondence[email protected]
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Hong Kan Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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Stacey Waugh Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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G. Roger Miller Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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Claud Johnson Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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Jenny R. Roberts Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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William Travis Goldsmith Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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Mark Jackson Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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Walter McKinney Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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David Frazer Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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Michael L. Kashon Biostatistics and Epidemiology Branch. Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
&
Vincent Castranova Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
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Pages 1397-1404 | Published online: 14 Sep 2011

Citations (28)

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K. Krajnak, S. Waugh, Ab Stefaniak, D Schwegler-Berry, Ka Roach, M Barger & Jr. Roberts. (2019) Exposure to graphene nanoparticles induces changes in measures of vascular/renal function in a load and form-dependent manner in mice. Journal of Toxicology and Environmental Health, Part A 82:12, pages 711-726.
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Kevin M. Stroski, Gregg Tomy & Vince Palace. (2019) The current state of knowledge for toxicity of corexit EC9500A dispersant: a review. Critical Reviews in Environmental Science and Technology 49:2, pages 81-103.
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Lawrence S. Engel, Richard K. Kwok, Aubrey K. Miller, Aaron Blair, Matthew D. Curry, John A. McGrath & Dale P. Sandler. (2017) The Gulf Long-Term Follow-Up Study (GuLF STUDY): Biospecimen collection at enrollment. Journal of Toxicology and Environmental Health, Part A 80:4, pages 218-229.
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Blanca Laffon, Eduardo Pásaro & Vanessa Valdiglesias. (2016) Effects of exposure to oil spills on human health: Updated review. Journal of Toxicology and Environmental Health, Part B 19:3-4, pages 105-128.
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Hong Kan, Zhongxin Wu, Yen-Chang Lin, Teh-Hsun Chen, Jared L Cumpston, Michael L Kashon, Steve Leonard, Albert E Munson & Vincent Castranova. (2014) The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide. Nanotoxicology 8:4, pages 447-454.
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Rachel Aileen Brewton, Richard Fulford & Robert J. Griffitt. (2013) Gene Expression and Growth as Indicators of Effects of the BP Deepwater Horizon Oil Spill on Spotted Seatrout (Cynoscion nebulosus). Journal of Toxicology and Environmental Health, Part A 76:21, pages 1198-1209.
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Yongli Shi, Astrid M. Roy-Engel & He Wang. (2013) Effects of Corexit Dispersants on Cytotoxicity Parameters in a Cultured Human Bronchial Airway Cells, BEAS-2B. Journal of Toxicology and Environmental Health, Part A 76:13, pages 827-835.
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Jenny R. Roberts, Walter McKinney, Hong Kan, Kristine Krajnak, David G. Frazer, Treye A. Thomas, Stacey Waugh, Allison Kenyon, Robert I. MacCuspie, Vincent A. Hackley & Vincent Castranova. (2013) Pulmonary and Cardiovascular Responses of Rats to Inhalation of Silver Nanoparticles. Journal of Toxicology and Environmental Health, Part A 76:11, pages 651-668.
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W. McKinney, M. Jackson, T. M. Sager, J. S. Reynolds, B. T. Chen, A. Afshari, K. Krajnak, S. Waugh, C. Johnson, R. R. Mercer, D. G. Frazer, T. A. Thomas & V. Castranova. (2012) Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles. Inhalation Toxicology 24:7, pages 447-457.
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William Travis Goldsmith, Walter McKinney, Mark Jackson, Brandon Law, Toni Bledsoe, Paul Siegel, Jared Cumpston & David Frazer. (2011) A Computer-Controlled Whole-Body Inhalation Exposure System for the Oil Dispersant COREXIT EC9500A. Journal of Toxicology and Environmental Health, Part A 74:21, pages 1368-1380.
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Articles from other publishers (18)

Sreekumar Othumpangat & Jeffrey S. Fedan. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 79 83 .
Kristine Krajnak, Kristen A. Russ, Walter McKinney, Stacey Waugh, Wen Zheng, Hong Kan, Michael L. Kashon, Jared Cumpston & Jeffrey S. Fedan. (2022) Biological effects of crude oil vapor. IV. Cardiovascular effects. Toxicology and Applied Pharmacology 447, pages 116071.
Crossref
Susan Arnold, Patricia A Stewart, Gregory C Pratt, Gurumurthy Ramachandran, Richard K Kwok, Lawrence S Engel, Dale P Sandler & Mark R Stenzel. (2022) Estimation of Aerosol Concentrations of Oil Dispersants COREXIT™ EC9527A and EC9500A during the Deepwater Horizon Oil Spill Response and Clean-up Operations . Annals of Work Exposures and Health 66:Supplement_1, pages i188-i202.
Crossref
Hristina Denic-Roberts, Nicole Rowley, Mark C. Haigney, Kate Christenbury, John Barrett, Dana L. Thomas, Lawrence S. Engel & Jennifer A. Rusiecki. (2022) Acute and longer-term cardiovascular conditions in the Deepwater Horizon Oil Spill Coast Guard Cohort. Environment International 158, pages 106937.
Crossref
Amanda C. Weiner, Megan E. Roegner & R. Douglas Watson. (2021) Effect of a chemical dispersant (Corexit 9500A) on the structure and ion transport function of blue crab (Callinectes sapidus) gills. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 247, pages 109070.
Crossref
Kristine Krajnak, Hong Kan, Kristen A. Russ, Walter McKinney, Stacey Waugh, Wen Zheng, Michael L. Kashon, Claud Johnson, Jared Cumpston & Jeffrey S. Fedan. (2020) Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects. Toxicology and Applied Pharmacology 406, pages 115242.
Crossref
Dana Stahl. 2020. Health and Safety in Emergency Management and Response. Health and Safety in Emergency Management and Response 1 37 .
Chike G. Ezeh, Chia-Yu Chen & Kyriakos D. Papadopoulos. (2018) Mobilization of n-hexadecane in porous media using food grade amphiphiles. Colloids and Surfaces A: Physicochemical and Engineering Aspects 558, pages 123-129.
Crossref
Elizabeth R. Jones, Christopher J. Martyniuk, Jeffrey M. Morris, Michelle O. Krasnec & Robert J. Griffitt. (2017) Exposure to Deepwater Horizon oil and Corexit 9500 at low concentrations induces transcriptional changes and alters immune transcriptional pathways in sheepshead minnows. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 23, pages 8-16.
Crossref
Emily Harville, Arti Shankar, Leah Zilversmit & Pierre Buekens. (2017) Self-Reported Oil Spill Exposure and Pregnancy Complications: The GROWH Study. International Journal of Environmental Research and Public Health 14:7, pages 692.
Crossref
Marusia Popovech. (2017) Analysis of Hazards of Dispersant Constituents and Review of Toxicological Studies. International Oil Spill Conference Proceedings 2017:1, pages 311-330.
Crossref
Christine V. Fiorello, Kate Freeman, Becky A. Elias, Emily Whitmer & Michael H. Ziccardi. (2016) Ophthalmic effects of petroleum dispersant exposure on common murres (Uria aalge): An experimental study. Marine Pollution Bulletin 113:1-2, pages 387-391.
Crossref
Yanling Chen & David H. Reese. (2016) Corexit-EC9527A Disrupts Retinol Signaling and Neuronal Differentiation in P19 Embryonal Pluripotent Cells. PLOS ONE 11:9, pages e0163724.
Crossref
Roger C. Prince. (2015) Oil Spill Dispersants: Boon or Bane?. Environmental Science & Technology 49:11, pages 6376-6384.
Crossref
Fu Jun Li, Ryan N. Duggal, Octavio M. Oliva, Suman Karki, Ranu Surolia, Zheng Wang, R. Douglas Watson, Victor J. Thannickal, Mickie Powell, Stephen Watts, Tejaswini Kulkarni, Hitesh Batra, Subhashini Bolisetty, Anupam Agarwal & Veena B. Antony. (2015) Heme Oxygenase-1 Protects Corexit 9500A-Induced Respiratory Epithelial Injury across Species. PLOS ONE 10:4, pages e0122275.
Crossref
Jasmin C. Athas, Kelly Jun, Caitlyn McCafferty, Olasehinde Owoseni, Vijay T. John & Srinivasa R. Raghavan. (2014) An Effective Dispersant for Oil Spills Based on Food-Grade Amphiphiles. Langmuir 30:31, pages 9285-9294.
Crossref
Jenny R. RobertsStacey E. AndersonHong KanKristine KrajnakJanet A. ThompsonAllison KenyonWilliam T. GoldsmithWalter McKinneyDavid G. FrazerMark JacksonJeffrey S. Fedan. (2015) Evaluation of Pulmonary and Systemic Toxicity of Oil Dispersant (COREXIT EC9500A ® ) following Acute Repeated Inhalation Exposure . Environmental Health Insights 8s1, pages EHI.S15262.
Crossref
John H. Paul, David Hollander, Paula Coble, Kendra L. Daly, Sue Murasko, David English, Jonelle Basso, Jennifer Delaney, Lauren McDaniel & Charles W. Kovach. (2013) Toxicity and Mutagenicity of Gulf of Mexico Waters During and After the Deepwater Horizon Oil Spill. Environmental Science & Technology 47:17, pages 9651-9659.
Crossref

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