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Original Articles

Generalization of the Prion Hypothesis to Other Neurodegenerative Diseases: An Imperfect Fit

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Pages 1433-1459 | Published online: 01 Nov 2011

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Calvin C. Willhite, Nataliya A. Karyakina, Robert A. Yokel, Nagarajkumar Yenugadhati, Thomas M. Wisniewski, Ian M.F. Arnold, Franco Momoli & Daniel Krewski. (2014) Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts. Critical Reviews in Toxicology 44:sup4, pages 1-80.
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Leslie I Grad, Edward Pokrishevsky, Judith M Silverman & Neil R Cashman. (2014) Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding. Prion 8:5, pages 331-335.
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. (2013) Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14:sup2, pages 1-63.
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Glenda Halliday, Heather McCann & Claire Shepherd. (2012) Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?. Expert Review of Neurotherapeutics 12:6, pages 673-686.
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Calvin C. Willhite, Gwendolyn L. Ball & Clifton J. McLellan. (2012) Total allowable concentrations of monomeric inorganic aluminum and hydrated aluminum silicates in drinking water. Critical Reviews in Toxicology 42:5, pages 358-442.
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Articles from other publishers (41)

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Rehana K. Leak, Matthew P. Frosch, Thomas G. Beach & Glenda M. Halliday. (2019) Alpha-synuclein: prion or prion-like?. Acta Neuropathologica 138:4, pages 509-514.
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Lorane I. da S. Hage-Melim, Jaderson V. Ferreira, Nayana K.S. de Oliveira, Lenir C. Correia, Marcos R.S. Almeida, João G.C. Poiani, Carlton A. Taft & Carlos H.T. de Paula da Silva. (2019) The Impact of Natural Compounds on the Treatment of Neurodegenerative Diseases. Current Organic Chemistry 23:3, pages 335-360.
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Franco Cauda, Andrea Nani, Jordi Manuello, Enrico Premi, Sara Palermo, Karina Tatu, Sergio Duca, Peter T Fox & Tommaso Costa. (2018) Brain structural alterations are distributed following functional, anatomic and genetic connectivity. Brain 141:11, pages 3211-3232.
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Franco Cauda, Andrea Nani, Tommaso Costa, Sara Palermo, Karina Tatu, Jordi Manuello, Sergio Duca, Peter T. Fox & Roberto Keller. (2018) The morphometric co‐atrophy networking of schizophrenia, autistic and obsessive spectrum disorders. Human Brain Mapping 39:5, pages 1898-1928.
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Jordi Manuello, Andrea Nani, Enrico Premi, Barbara Borroni, Tommaso Costa, Karina Tatu, Donato Liloia, Sergio Duca & Franco Cauda. (2018) The Pathoconnectivity Profile of Alzheimer’s Disease: A Morphometric Coalteration Network Analysis. Frontiers in Neurology 8.
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W. Allison, Michèle DuVal, Kim Nguyen-Phuoc & Patricia Leighton. (2017) Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology. International Journal of Molecular Sciences 18:10, pages 2223.
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Abhisek Mukherjee, Diego Morales-Scheihing, Natalia Salvadores, Ines Moreno-Gonzalez, Cesar Gonzalez, Kathleen Taylor-Presse, Nicolas Mendez, Mohammad Shahnawaz, A. Osama Gaber, Omaima M. Sabek, Daniel W. Fraga & Claudio Soto. (2017) Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism. Journal of Experimental Medicine 214:9, pages 2591-2610.
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Leslie I. Grad, Guy A. Rouleau, John Ravits & Neil R. Cashman. (2017) Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS). Cold Spring Harbor Perspectives in Medicine 7:8, pages a024117.
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James C. Giffin, Robert C. Richards, Cheryl Craft, Nusrat Jahan, Cindy Leggiadro, Thierry Chopin, Michael Szemerda, Shawna L. MacKinnon & K.Vanya Ewart. (2017) An extract of the marine alga Alaria esculenta modulates α-synuclein folding and amyloid formation. Neuroscience Letters 644, pages 87-93.
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Heiko Braak & Kelly Del Tredici. (2016) Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases. Cold Spring Harbor Perspectives in Biology 8:11, pages a023630.
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Sriram Balusu, Elien Van Wonterghem, Riet De Rycke, Koen Raemdonck, Stephan Stremersch, Kris Gevaert, Marjana Brkic, Delphine Demeestere, Valerie Vanhooren, An Hendrix, Claude Libert & Roosmarijn E Vandenbroucke. (2016) Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus‐derived extracellular vesicles. EMBO Molecular Medicine 8:10, pages 1162-1183.
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Dominic M. Walsh & Dennis J. Selkoe. (2016) A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nature Reviews Neuroscience 17:4, pages 251-260.
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Edward Pokrishevsky, Leslie I. Grad & Neil R. Cashman. (2016) TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion. Scientific Reports 6:1.
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Aneesha Chauhan & Alexander F. Jeans. (2015) Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence. Neurology Research International 2015, pages 1-8.
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Petra Steinacker, Christian Berner, Dietmar R Thal, Johannes Attems, Albert C Ludolph & Markus Otto. (2014) Protease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot. Acta Neuropathologica Communications 2:1.
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Michael Beekes, Achim Thomzig, Walter J. Schulz-Schaeffer & Reinhard Burger. (2014) Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?. Acta Neuropathologica 128:4, pages 463-476.
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Marco Sandri & Jeffrey Robbins. (2014) Proteotoxicity: An underappreciated pathology in cardiac disease. Journal of Molecular and Cellular Cardiology 71, pages 3-10.
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Irene Tsilioni, Smaro Panagiotidou & Theoharis C. Theoharides. (2014) Exosomes in Neurologic and Psychiatric Disorders. Clinical Therapeutics 36:6, pages 882-888.
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Anuradha Kalani, Alka Tyagi & Neetu Tyagi. (2013) Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics. Molecular Neurobiology 49:1, pages 590-600.
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Walker S. Jackson. (2014) Selective vulnerability to neurodegenerative disease: the curious case of Prion Protein. Disease Models & Mechanisms 7:1, pages 21-29.
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Samreen Amani & Aabgeena Naeem. (2013) Understanding protein folding from globular to amyloid state. Process Biochemistry 48:11, pages 1651-1664.
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Jason D. Warren, Jonathan D. Rohrer, Jonathan M. Schott, Nick C. Fox, John Hardy & Martin N. Rossor. (2013) Molecular nexopathies: a new paradigm of neurodegenerative disease. Trends in Neurosciences 36:10, pages 561-569.
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Vikram Khipple Mulligan & Avijit Chakrabartty. (2013) Protein misfolding in the late-onset neurodegenerative diseases: Common themes and the unique case of amyotrophic lateral sclerosis. Proteins: Structure, Function, and Bioinformatics 81:8, pages 1285-1303.
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Karolyn J. Forget, Guillaume Tremblay & Xavier Roucou. (2013) p53 Aggregates Penetrate Cells and Induce the Co-Aggregation of Intracellular p53. PLoS ONE 8:7, pages e69242.
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Maddalena Costanzo & Chiara Zurzolo. (2013) The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration. Biochemical Journal 452:1, pages 1-17.
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Roberto E. Sica. (2012) Is amyotrophic lateral sclerosis a primary astrocytic disease?. Medical Hypotheses 79:6, pages 819-822.
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Diego Guidolin, Luigi F. Agnati, Giovanna Albertin, Cinzia Tortorella & Kjell Fuxe. (2012) Bioinformatics aggregation predictors in the study of protein conformational diseases of the human nervous system. ELECTROPHORESIS 33:24, pages 3669-3679.
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Sheng-Rong Meng, Ying-Zhu Zhu, Tong Guo, Xiao-Ling Liu, Jie Chen & Yi Liang. (2012) Fibril-Forming Motifs Are Essential and Sufficient for the Fibrillization of Human Tau. PLoS ONE 7:6, pages e38903.
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Edward Pokrishevsky, Leslie I. Grad, Masoud Yousefi, Jing Wang, Ian R. Mackenzie & Neil R. Cashman. (2012) Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis. PLoS ONE 7:4, pages e35050.
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