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Original Articles

Everolimus Enhances Gemcitabine-Induced Cytotoxicity in Bladder-Cancer Cell Lines

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Pages 788-799 | Published online: 12 Jul 2012

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P. A. Oliveira, R. M. Gil da Costa, C. Vasconcelos-Nóbrega, R. Arantes-Rodrigues & R. Pinto-Leite. (2016) Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery. Expert Opinion on Drug Discovery 11:6, pages 599-607.
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Articles from other publishers (19)

Kelly Ward, Mark O Kitchen, Suresh-Jay Mathias, Farhat L Khanim & Richard T. Bryan. (2022) Novel intravesical therapeutics in the treatment of non-muscle invasive bladder cancer: Horizon scanning. Frontiers in Surgery 9.
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Masahiro Yamamoto, Shuhei Suzuki, Keita Togashi, Asuka Sugai, Masashi Okada & Chifumi Kitanaka. (2022) Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins. Cancers 14:7, pages 1706.
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Xinghua Gao, Jikai Liu, Daming Fan, Xiaofeng Li, Zhiqing Fang, Keqiang Yan & Yidong Fan. (2021) Berberine enhances gemcitabine‑induced cytotoxicity in bladder cancer by downregulating Rad51 expression through inactivating the PI3K/Akt pathway. Oncology Reports 47:2.
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Sílvia Lemos, Belém Sampaio-Marques, Paula Ludovico, Isabel Gaivão, Carlos Palmeira, Gabriela Martins, Francisco Peixoto, Rosário Pinto-Leite & Paula Oliveira. (2020) Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line. Anti-Cancer Drugs 31:5, pages 507-517.
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Luigi Formisano, Fabiana Napolitano, Roberta Rosa, Valentina D’Amato, Alberto Servetto, Roberta Marciano, Pietro De Placido, Cataldo Bianco & Roberto Bianco. (2020) Mechanisms of resistance to mTOR inhibitors. Critical Reviews in Oncology/Hematology 147, pages 102886.
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Guido Dalbagni, Nicole Benfante, Daniel D. Sjoberg, Bernard H. Bochner, S. Machele Donat, Harry W. Herr, Asia S. Mc Coy, Alicia J. Fahrner, Caitlyn Retinger, Jonathan E. Rosenberg & Dean F. Bajorin. (2017) Single Arm Phase I/II Study of Everolimus and Intravesical Gemcitabine in Patients with Primary or Secondary Carcinoma In Situ of the Bladder who failed Bacillus Calmette Guerin (NCT01259063). Bladder Cancer 3:2, pages 113-119.
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Vanya Bogoeva, Monica Siksj?Kristin G. S?terb?Thor Bernt Mel?Astrid Bj?rk?y, Mikael Lindgren & Odrun A. Gederaas. (2016) Ruthenium porphyrin-induced photodamage in bladder cancer cells. Photodiagnosis and Photodynamic Therapy 14, pages 9-17.
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Wassim Abida, Matthew I. Milowsky, Irina Ostrovnaya, Scott R. Gerst, Jonathan E. Rosenberg, Martin H. Voss, Andrea B. Apolo, Ashley M. Regazzi, Asia S. McCoy, Mariel E. Boyd & Dean F. Bajorin. (2016) Phase I Study of Everolimus in Combination with Gemcitabine and Split-Dose Cisplatin in Advanced Urothelial Carcinoma. Bladder Cancer 2:1, pages 111-117.
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Dominic H. Tang & Sam S. Chang. (2015) Management of carcinoma in situ of the bladder: best practice and recent developments . Therapeutic Advances in Urology 7:6, pages 351-364.
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C?u Costa, Sofia Pereira, Lu?s Lima, Andreia Peixoto, Elisabete Fernandes, Diogo Neves, Manuel Neves, Cristiana Gaiteiro, Ana Tavares, Rui M. Gil da Costa, Ricardo Cruz, Teresina Amaro, Paula A. Oliveira, Jos? Alexandre Ferreira & L?cio L. Santos. (2015) Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics. PLOS ONE 10:11, pages e0141253.
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JULIETA AFONSO, ADHEMAR LONGATTO-FILHO, VITOR MOREIRA DA SILVA, TERESINA AMARO & LÚCIO L. SANTOS. (2014) Phospho-mTOR in non-tumour and tumour bladder urothelium: Pattern of expression and impact on urothelial bladder cancer patients. Oncology Letters 8:4, pages 1447-1454.
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Rosário Pinto-Leite, Regina Arantes-Rodrigues, Rita Ferreira, Carlos Palmeira, Paula A. Oliveira & Lúcio Santos. (2014) Treatment of muscle invasive urinary bladders tumors: A potential role of the mTOR inhibitors. Biomedicine & Aging Pathology 4:3, pages 169-178.
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Rosário Pinto-Leite, Isabel Carreira, Joana Melo, Susana Isabel Ferreira, Ilda Ribeiro, Jaqueline Ferreira, Marco Filipe, Carina Bernardo, Regina Arantes-Rodrigues, Paula Oliveira & Lúcio Santos. (2014) Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder cancer. Tumor Biology 35:5, pages 4599-4617.
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Rosário Pinto-Leite, Regina Arantes-Rodrigues, Rita Ferreira, Carlos Palmeira, Aura Colaço, Vítor Moreira da Silva, Paula Oliveira & Lúcio Lara Santos. (2014) Temsirolimus improves cytotoxic efficacy of cisplatin and gemcitabine against urinary bladder cancer cell lines. Urologic Oncology: Seminars and Original Investigations 32:1, pages 41.e11-41.e22.
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Kai Tang, Yi Lin & Li‐Ming Li. (2013) The Role of Phenethyl Isothiocyanate on Bladder Cancer ADM Resistance Reversal and Its Molecular Mechanism. The Anatomical Record 296:6, pages 899-906.
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Regina Arantes-Rodrigues, Rosário Pinto-Leite, Rita Ferreira, Maria João Neuparth, Maria João Pires, Isabel Gaivão, Carlos Palmeira, Lúcio Santos, Aura Colaço & Paula Oliveira. (2013) Meloxicam in the treatment of in vitro and in vivo models of urinary bladder cancer. Biomedicine & Pharmacotherapy 67:4, pages 277-284.
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YUCHEN CAI, QING XIA, QUANGUAN SU, RONGZHEN LUO, YUELI SUN, YANXIA SHI & WENQI JIANG. (2013) mTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death, in human nasopharyngeal carcinoma cells. International Journal of Molecular Medicine 31:4, pages 904-912.
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Rosário Pinto-Leite, Regina Arantes-Rodrigues, Carlos Palmeira, Bruno Colaço, Carlos Lopes, Aura Colaço, Céu Costa, Vítor Moreira da Silva, Paula Oliveira & Lúcio Santos. (2013) Everolimus combined with cisplatin has a potential role in treatment of urothelial bladder cancer. Biomedicine & Pharmacotherapy 67:2, pages 116-121.
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LING LIU, LIANSHENG GONG, YANGDE ZHANG & NIANFENG LI. (2013) Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus. Experimental and Therapeutic Medicine 5:1, pages 338-342.
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