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Journal of Toxicology and Environmental Health, Part A
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Volume 75, 2012 - Issue 19-20: Second Symposium on Interdisciplinary Activities in Environmental Toxicology in North Rhine-Westphalia, Germany: Part Two
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Original Articles

Surveillance Program for Former PCB-Exposed Workers of a Transformer and Capacitor Recycling Company, Family Members, Employees of Surrounding Companies, and Area Residents—Executive Summary

Thomas Kraus Department of Occupational and Social Medicine, RWTH Aachen University, Aachen, GermanyCorrespondence[email protected]
,
Monika Gube Department of Occupational and Social Medicine, RWTH Aachen University, Aachen, Germany
,
Jessica Lang Department of Occupational and Social Medicine, RWTH Aachen University, Aachen, Germany
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Andre Esser Department of Occupational and Social Medicine, RWTH Aachen University, Aachen, Germany
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Walter Sturm Section on Neuropsychology at the Department of Neurology, RWTH Aachen University, Aachen, Germany
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Bruno Fimm Section on Neuropsychology at the Department of Neurology, RWTH Aachen University, Aachen, Germany
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Klaus Willmes Section on Neuropsychology at the Department of Neurology, RWTH Aachen University, Aachen, Germany
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Joseph Neulen Department of Gynecological Endocrinology and Reproductive Medicine, RWTH Aachen University, Aachen, Germany
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Jens Malte Baron Department of Dermatology and Allergology, RWTH Aachen University, Aachen, Germany
,
Hans Merk Department of Dermatology and Allergology, RWTH Aachen University, Aachen, Germany
,
Thomas Schettgen Department of Occupational and Social Medicine, RWTH Aachen University, Aachen, Germany
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Kerstin Konrad Clinical Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, RWTH Aachen University, Aachen, Germany
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Sabine Deisz Department of Pediatrics and Adolescent Medicine, RWTH Aachen University, Aachen, Germany
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Lothar Rink Department of Immunology, RWTH Aachen University, Aachen, Germany
,
Michael Hagmann NRW Institute of Health and Work, Düsseldorf, Germany
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Birgit Fillies NRW Institute of Health and Work, Düsseldorf, Germany; German Social Accident Insurance Institution for the Health and Welfare Services, BGW, Köln, Germany
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Wolfgang Zschiesche Employers' Liability Insurance Association Electronic Textile Energy Media Products, BG ETEM, Köln, Germany
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Jürgen Wittsiepe Department for Hygiene and Social and Environmental Medicine, RUB, Ruhr-Universität Bochum, Bochum, Germany
&
Michael Wilhelm for the HELPcB-Group Department for Hygiene and Social and Environmental Medicine, RUB, Ruhr-Universität Bochum, Bochum, Germany
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Pages 1241-1247 | Published online: 20 Sep 2012

Citations (33)

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Read on this site (3)

Theresa Knaup, Andre Esser, Thomas Schettgen, Thomas Kraus & Andrea Kaifie. (2021) Which factors influence the frequency of participation in longitudinal cohort studies? - An analysis of demographics, social factors, and medical preconditions in participants of the health effects in high level exposure to polychlorinated biphenyls (HELPcB) cohort. Journal of Toxicology and Environmental Health, Part A 84:23, pages 973-985.
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Andrea Kaifie, Thomas Schettgen, Monika Gube, Patrick Ziegler, Thomas Kraus & André Esser. (2019) Functional and structural liver abnormalities in former PCB exposed workers – analyses from the HELPcB cohort. Journal of Toxicology and Environmental Health, Part A 82:1, pages 52-61.
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A. Esser, P. M. Gaum, T. Schettgen, T. Kraus, M. Gube & J. Lang. (2015) Effect of Occupational Polychlorinated Biphenyls Exposure on Quality-Adjusted Life Years Over Time at the HELPcB Surveillance Program. Journal of Toxicology and Environmental Health, Part A 78:2, pages 132-150.
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Articles from other publishers (30)

Isabella Randerath, Natalia Quinete, Julian Peter Müller, Julia Stingl, Jens Bertram, Thomas Schettgen, Thomas Kraus & Patrick Ziegler. (2023) Partial dechlorination of 2,4,4′-trichlorobiphenyl (PCB 28) mediated by recombinant human CYP1A2. Archives of Toxicology.
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Jens Rengelshausen, Isabella Randerath, Thomas Schettgen, Andre Esser, Andrea Kaifie, Jessica Lang, Thomas Kraus & Patrick Ziegler. (2023) Ten years after: findings from the medical surveillance program on Health Effects in High-Level Exposure to PCB (HELPcB). Archives of Toxicology 97:10, pages 2609-2623.
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Stephanie Sontag, Ledio Bocova, Wouter H G Hubens, Selina Nüchtern, Matthis Schnitker, Thomas Look, Kema M Schröder, Birgit Plümäkers, Vithurithra Tharmapalan, Martina Wessiepe, Thomas Kraus, Jan Kramer, Lothar Rink, Steffen Koschmieder & Wolfgang Wagner. (2022) Toward Clinical Application of Leukocyte Counts Based on Targeted DNA Methylation Analysis. Clinical Chemistry 68:5, pages 646-656.
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Marike Leijs, Katharina Fietkau, Hans F. Merk, Thomas Schettgen, Thomas Kraus & André Esser. (2021) Upregulation of CCL7, CCL20, CXCL2, IL-1β, IL-6 and MMP-9 in Skin Samples of PCB Exposed Individuals—A Preliminary Study. International Journal of Environmental Research and Public Health 18:18, pages 9711.
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André Esser, Patrick Ziegler, Andrea Kaifie, Thomas Kraus & Thomas Schettgen. (2021) Modelling past human internal exposure to lower chlorinated indicator PCBs using proxies – A calculation based on multiple longitudinal PCB analyses. Science of The Total Environment 784, pages 147250.
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Ann Colles, Dries Coertjens, Bert Morrens, Elly Den Hond, Melissa Paulussen, Liesbeth Bruckers, Eva Govarts, Adrian Covaci, Gudrun Koppen, Kim Croes, Vera Nelen, Nicolas Van Larebeke, Stefaan De Henauw, Tine Fierens, Griet Van Gestel, Hana Chovanova, Maja Mampaey, Karen Van Campenhout, Ilse Loots, Willy Baeyens & Greet Schoeters. (2021) Human Biomonitoring Data Enables Evidence-Informed Policy to Reduce Internal Exposure to Persistent Organic Compounds: A Case Study. International Journal of Environmental Research and Public Health 18:11, pages 5559.
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Petra Maria Gaum, Isabell Kuczynski, Thomas Schettgen, Franziska Maria Putschögl, Thomas Kraus, Bruno Fimm & Jessica Lang. (2021) Adverse health effects of PCBs on fine motor performance – Analysis of a neurophysiological pathway in the HELPcB surveillance program. NeuroToxicology 84, pages 146-154.
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André Esser, Patrick Ziegler, Andrea Kaifie, Thomas Kraus & Thomas Schettgen. (2021) Estimating plasma half-lives of dioxin like and non-dioxin like polychlorinated biphenyls after occupational exposure in the German HELPcB cohort. International Journal of Hygiene and Environmental Health 232, pages 113667.
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T. Idda, C. Bonas, J. Hoffmann, J. Bertram, N. Quinete, T. Schettgen, K. Fietkau, A. Esser, M. B. Stope, M. M. Leijs, J. M. Baron, T. Kraus, A. Voigt & P. Ziegler. (2020) Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Scientific Reports 10:1.
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Petra Maria Gaum, Viktoria Stefanie Vida, Thomas Schettgen, André Esser, Thomas Kraus, Monika Gube & Jessica Lang. (2020) Cross-Sectional and Longitudinal Effects of PCB Exposure on Human Stress Hormones in the German HELPcB Surveillance Program. International Journal of Environmental Research and Public Health 17:13, pages 4708.
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Andrea Kaifie, Thomas Schettgen, Manfred de Hoogd, Thomas Kraus & Andre Esser. (2019) Contamination pathways of polychlorinated biphenyls (PCBs) – From the worker to the family. International Journal of Hygiene and Environmental Health 222:8, pages 1109-1114.
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Marike M. Leijs, Lin Gan, Patrick De Boever, André Esser, Philipp M. Amann, Patrick Ziegler, Katharina Fietkau, Thomas Schettgen, Thomas Kraus, Hans F. Merk & Jens M. Baron. (2019) Altered Gene Expression in Dioxin-Like and Non-Dioxin-Like PCB Exposed Peripheral Blood Mononuclear Cells. International Journal of Environmental Research and Public Health 16:12, pages 2090.
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Petra Gaum, Monika Gube, André Esser, Thomas Schettgen, Natalia Quinete, Jens Bertram, Franziska Putschögl, Thomas Kraus & Jessica Lang. (2019) Depressive Symptoms After PCB Exposure: Hypotheses for Underlying Pathomechanisms via the Thyroid and Dopamine System. International Journal of Environmental Research and Public Health 16:6, pages 950.
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Theresa Vasko, Jenny Hoffmann, Sonja Gostek, Thomas Schettgen, Natalia Quinete, Christian Preisinger, Thomas Kraus & Patrick Ziegler. (2018) Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls. Scientific Reports 8:1.
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Marike M. Leijs, André Esser, Philipp M. Amann, Thomas Schettgen, Ruth Heise, Katharina Fietkau, Monika Gube, Hans F. Merk, Thomas Kraus & Jens M. Baron. (2018) Expression of CYP1A1, CYP1B1 and IL-1β in PBMCs and skin samples of PCB exposed individuals. Science of The Total Environment 642, pages 1429-1438.
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Marike M. Leijs, André Esser, Philipp M. Amann, Thomas Schettgen, Monika Gube, Hans F. Merk, Thomas Kraus & Jens M. Baron. (2018) Hyperpigmentation and higher incidence of cutaneous malignancies in moderate-high PCB- and dioxin exposed individuals. Environmental Research 164, pages 221-228.
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Petra Maria Gaum, Monika Gube, Thomas Schettgen, Franziska Maria Putschögl, Thomas Kraus, Bruno Fimm & Jessica Lang. (2017) Polychlorinated biphenyls and depression: cross-sectional and longitudinal investigation of a dopamine-related Neurochemical path in the German HELPcB surveillance program. Environmental Health 16:1.
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B. Fimm, W. Sturm, A. Esser, T. Schettgen, K. Willmes, J. Lang, P.M. Gaum & T. Kraus. (2017) Neuropsychological effects of occupational exposure to polychlorinated biphenyls. NeuroToxicology 63, pages 106-119.
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Monika Gube, Thomas Schettgen, Thomas Kraus, Christian Schikowsky, Andreas Heibges, Reinhard Klingel, Christian Hoffmann, Andreas Wiemeyer, Jewgeni Jacobson & André Esser. (2016) Use of plasma exchange or double filtration plasmapheresis to reduce body burden of polychlorinated biphenyls: A pilot trial. Journal of Exposure Science & Environmental Epidemiology 27:4, pages 444-450.
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Natalia Quinete, André Esser, Thomas Kraus & Thomas Schettgen. (2017) PCB 28 metabolites elimination kinetics in human plasma on a real case scenario: Study of hydroxylated polychlorinated biphenyl (OH-PCB) metabolites of PCB 28 in a highly exposed German Cohort. Toxicology Letters 276, pages 100-107.
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Susanne Ziegler, Thomas Schettgen, Fabian Beier, Stefan Wilop, Natalia Quinete, Andre Esser, Behzad Kharabi Masouleh, Monica S. V. Ferreira, Lucia Vankann, Peter Uciechowski, Lothar Rink, Thomas Kraus, Tim H. Brümmendorf & Patrick Ziegler. (2016) Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure. Archives of Toxicology 91:1, pages 289-300.
Crossref
Natalia Quinete, André Esser, Thomas Kraus & Thomas Schettgen. (2016) Determination of hydroxylated polychlorinated biphenyls (OH-PCBs) in human urine in a highly occupationally exposed German cohort: New prospects for urinary biomarkers of PCB exposure. Environment International 97, pages 171-179.
Crossref
André Esser, Thomas Schettgen, Monika Gube, Alexander Koch & Thomas Kraus. (2016) Association between polychlorinated biphenyls and diabetes mellitus in the German HELPcB cohort. International Journal of Hygiene and Environmental Health 219:6, pages 557-565.
Crossref
Petra M. Gaum, Jessica Lang, André Esser, Thomas Schettgen, Joseph Neulen, Thomas Kraus & Monika Gube. (2016) Exposure to polychlorinated biphenyls and the thyroid gland – examining and discussing possible longitudinal health effects in humans. Environmental Research 148, pages 112-121.
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Hajo Haase, Astrid Fahlenkamp, Thomas Schettgen, Andre Esser, Monika Gube, Patrick Ziegler, Thomas Kraus & Lothar Rink. (2016) Immunotoxicity Monitoring in a Population Exposed to Polychlorinated Biphenyls. International Journal of Environmental Research and Public Health 13:3, pages 295.
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Natalia Quinete, Thomas Kraus, Vladimir N. Belov, Christina Aretz, André Esser & Thomas Schettgen. (2015) Fast determination of hydroxylated polychlorinated biphenyls in human plasma by online solid phase extraction coupled to liquid chromatography-tandem mass spectrometry. Analytica Chimica Acta 888, pages 94-102.
Crossref
Franziska Maria Putschögl, Petra Maria Gaum, Thomas Schettgen, Thomas Kraus, Monika Gube & Jessica Lang. (2015) Effects of occupational exposure to polychlorinated biphenyls on urinary metabolites of neurotransmitters: A cross-sectional and longitudinal perspective. International Journal of Hygiene and Environmental Health 218:5, pages 452-460.
Crossref
Petra M. Gaum, André Esser, Thomas Schettgen, Monika Gube, Thomas Kraus & Jessica Lang. (2014) Prevalence and incidence rates of mental syndromes after occupational exposure to polychlorinated biphenyls. International Journal of Hygiene and Environmental Health 217:7, pages 765-774.
Crossref
André Esser, Monika Gube, Thomas Schettgen, Thomas Kraus & Jessica Lang. (2014) QALY as evaluation tool in a health surveillance program. International Journal of Hygiene and Environmental Health 217:2-3, pages 399-404.
Crossref
Klaus Golka, Katja Ickstadt, Silvia Selinski, Jan G. Hengstler & Michael Wilhelm. (2013) Second symposium on Environmental Toxicology in North Rhine-Westphalia, Germany—interdisciplinary research activities in toxicology, statistics, hygiene and medicine: meeting report on a symposium held in Dortmund May 19–20, 2011. Archives of Toxicology 87:3, pages 555-561.
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