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Journal of Toxicology and Environmental Health, Part A
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Volume 83, 2020 - Issue 15-16
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Research Article

Characterization of the invitro cytotoxic effects of brachydins isolated from Fridericia platyphylla in a prostate cancer cell line

Higor Lopes Nunesa Departamento de Biologia Geral, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Paraná, BrasilView further author information
,
Katiuska Tuttisa Departamento de Biologia Geral, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Paraná, BrasilView further author information
,
Juliana Mara Serpelonia Departamento de Biologia Geral, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Paraná, BrasilCorrespondence[email protected]
View further author information
,
Jessyane Rodrigues do Nascimentob Departamento De Química, Centro de Ciências Exatas e Tecnologia, Universidade Federal do Maranhão, São Luís, Maranhão, BrasilView further author information
,
Claudia Quintino da Rochab Departamento De Química, Centro de Ciências Exatas e Tecnologia, Universidade Federal do Maranhão, São Luís, Maranhão, BrasilView further author information
,
Viviane Aline Oliveira Silvac Centro de Pesquisa em Oncologia Molecular, Hospital de Câncer de Barretos, Barretos, São Paulo, BrasilView further author information
,
André van Helvoort Lengertc Centro de Pesquisa em Oncologia Molecular, Hospital de Câncer de Barretos, Barretos, São Paulo, BrasilView further author information
,
Rui Manuel Reisc Centro de Pesquisa em Oncologia Molecular, Hospital de Câncer de Barretos, Barretos, São Paulo, Brasil;d Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;e ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, PortugalView further author information
&
Ilce Mara de Syllos Cólusa Departamento de Biologia Geral, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Paraná, BrasilView further author information
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Pages 547-558 | Published online: 26 Jun 2020

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Vera Lucia Maciel-Silva, Claudia Quintino da Rocha, Luciana Magalhães Rebelo Alencar, Patrícia Valéria Castelo-Branco, Israel Higino de Sousa, Ana Paula Azevedo-Santos, André Alvares Marques Vale, Silvio Gomes Monteiro, Rossy-Eric Pereira Soares, Sulayne Janayna Araujo Guimarães, Jessyane Rodrigues do Nascimento & Silma Regina Ferreira Pereira. (2023) Unusual dimeric flavonoids (brachydins) induce ultrastructural membrane alterations associated with antitumor activity in cancer cell lines. Drug and Chemical Toxicology 46:4, pages 665-676.
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Paulo Michel Pinheiro Ferreira, Ian Jhemes Oliveira Sousa, Kamilla Nunes Machado, Leonel Antônio da Silva Neto, Milena Monteiro de Freitas, Ingredy Lopes dos Santos, Débora Caroline do Nascimento Rodrigues, Rayran Walter Ramos de Sousa, Antonielly Campinho dos Reis, Maria Luisa Lima Barreto do Nascimento, Ag-Anne Pereira Melo de Menezes, Andréa Mendes do Nascimento, José Roberto de Oliveira Ferreira, Ana Paula Peron & João Marcelo de Castro e Sousa. (2022) Antimitotic and toxicogenetic action of Stevia urticifolia aerial parts on proliferating vegetal and mammalian cells: in vitro and in vivo traditional and replacement methods. Journal of Toxicology and Environmental Health, Part A 85:18, pages 750-766.
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Altevir Rossato Viana, B. Godoy Noro, J. C. Lenz, M. Luiza Machado Teixeira, M. Bolson Serafin, R. Hörner, C. Franco, L. Maria Fontanari Krause, B. Stefanello Vizzotto & B. Jalfim Maraschin. (2022) Cytotoxic screening and antibacterial activity of Withaferin A. Journal of Toxicology and Environmental Health, Part A 85:16, pages 685-698.
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Ju Hwan Kim, Sangbong Jeon, Hyung-Do Choi, Jae-Hun Lee, Jun-Sang Bae, Nam Kim, Hyung-Gun Kim, Kyu-Bong Kim & Hak Rim Kim. (2021) Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence. Journal of Toxicology and Environmental Health, Part A 84:20, pages 846-857.
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Mariana Terezinha Selbach, Amanda Souza Scotti, Cleverson Costa Feistel, Caroline C. Nicolau, Daiana Dalberto, Natália Garcia dos Santos, Guilherme Borsoi, Alexandre Barros Falcão Ferraz, Ivana Grivicich, Guilherme Maurício Soares de Souza, Paola Chytry, Johnny Ferraz Dias, Dione Silva Corrêa & Juliana da Silva. (2021) Evaluation of the cytotoxic and genotoxic effects of Sida planicaulis Cav extract using human neuroblastoma cell line SH-SY5Y. Journal of Toxicology and Environmental Health, Part A 84:8, pages 345-355.
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Bruno Coêlho Cavalcanti, João Batista de Andrade Neto, Antônio Adailson de Sousa Silva, Francisco Stefânio Barreto, José Roberto de Oliveira Ferreira, Hemerson Iury Ferreira Magalhães, Cecília Rocha da Silva, Ícaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Hélio Vitoriano Nobre Júnior & Manoel Odorico Moraes. (2021) Chemopreventive effect of troxerutin against hydrogen peroxide-induced oxidative stress in human leukocytes through modulation of glutathione-dependent enzymes. Journal of Toxicology and Environmental Health, Part A 84:4, pages 137-151.
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Jamilson dos Santos Freire, Bianca Cristina dos Santos Fernandes, Julia Adelaide Cardeal da Silva, José Rafael da Silva Araújo, Pedro Marcos de Almeida, Joaquim Soares da Costa Júnior, Jurandy Nascimento da Silva, Sâmya Danielle Lima de Freitas & Francielle Alline Martins. (2020) Phytochemical and antioxidant characterization, cytogenotoxicity and antigenotoxicity of the fractions of the ethanolic extract of in Poincianella bracteosa (Tul.) L.P. Queiroz. Journal of Toxicology and Environmental Health, Part A 83:23-24, pages 730-747.
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Karoline Soares de Freitas, Iara Silva Squarisi, Nathália Oliveira Acésio, Heloiza Diniz Nicolella, Saulo Duarte Ozelin, Matheus Reis Santos de Melo, Ana Paula Prado Guissone, Gabriela Fernandes, Lívia Mara Silva, Ademar Alves da Silva Filho & Denise Crispim Tavares. (2020) Licochalcone A, a licorice flavonoid: antioxidant, cytotoxic, genotoxic, and chemopreventive potential. Journal of Toxicology and Environmental Health, Part A 83:21-22, pages 673-686.
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Articles from other publishers (7)

Jessyane Rodrigues do Nascimento, Beatriz Santiago de Matos Monteiro Lira, Matheus Oliveira do Nascimento, Gláucia Laís Nunes Lopes, Glaucio Monteiro Ferreira, Glécilla Colombelli de Souza Nunes, Renato Sonchini Gonçalves, André Luis Menezes Carvalho, Wagner Vilegas & Cláudia Quintino da Rocha. (2023) Innovative Microemulsion Loaded with Unusual Dimeric Flavonoids from Fridericia platyphylla (Cham.) L.G. Lohmann Roots. AAPS PharmSciTech 24:8.
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Francisco Laerte Lopes da Silva, Amanda Souza Scotti, Ana Letícia Hilário Garcia, Maria Luiza Brodt Lemes, Ivana Grivicich, Gabriela Mendonça dos Reis, Johnny Ferraz Dias, Fernanda Brião Menezes Boaretto, Jaqueline Nascimento Picada, Juliana da Silva & Alexandre de Barros Falcão Ferraz. (2023) Toxicological potential of Aloysia gratissima: Insights from chemical analysis and in vitro studies. Journal of Ethnopharmacology 314, pages 116614.
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Juliana Mara Serpeloni, Diego Luis Ribeiro, Gabriela Fátima Weiss, Larissa Cristina Bastos de Oliveira, Andressa Yuri Fujiike, Higor Lopes Nunes, Claudia Quintino da Rocha, Roberta Losi Guembarovski & Ilce Mara de Syllos Cólus. (2023) Flavonoid brachydin B decreases viability, proliferation, and migration in human metastatic prostate (DU145) cells grown in 2D and 3D culture models. Toxicology Research 12:2, pages 321-331.
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Margarita Dormousoglou, Ioanna Efthimiou, Maria Antonopoulou, Stefanos Dailianis, Giulia Herbst & Dimitris Vlastos. (2023) Phytochemical Analysis and Genotoxicological Evaluation of Prickly Pear Peel Extracts. Plants 12:7, pages 1537.
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Jessyane Rodrigues do Nascimento, Amanda de Jesus Alves Miranda, Felipe Costa Vieira, Carla Daniele Pinheiro Rodrigues, Luna Nascimento Vasconcelos, José Lima Pereira Filho, Auxiliadora Cristina Corrêa Barata Lopes, Marcelo Marucci Pereira Tangerina, Wagner Vilegas & Cláudia Quintino da Rocha. (2022) A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea. Pharmaceuticals 15:6, pages 658.
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Diego Luis Ribeiro, Katiuska Tuttis, Larissa Cristina Bastos de Oliveira, Juliana Mara Serpeloni, Izabela Natalia Faria Gomes, André van Helvoort Lengert, Cláudia Quintino da Rocha, Rui Manuel Reis, Ilce Mara de Syllos Cólus & Lusânia Maria Greggi Antunes. (2022) The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death. Pharmaceutics 14:5, pages 963.
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Larissa Cristina Bastos de Oliveira, Higor Lopes Nunes, Diego Luis Ribeiro, Jessyane Rodrigues do Nascimento, Cláudia Quintino da Rocha, Ilce Mara de Syllos Cólus & Juliana Mara Serpeloni. (2021) Aglycone flavonoid brachydin A shows selective cytotoxicity and antitumoral activity in human metastatic prostate (DU145) cancer cells. Cytotechnology 73:6, pages 761-774.
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