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Journal of Toxicology and Environmental Health, Part A
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Volume 83, 2020 - Issue 21-22
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Research Article

Licochalcone A, a licorice flavonoid: antioxidant, cytotoxic, genotoxic, and chemopreventive potential

Karoline Soares de Freitasa Laboratório de Mutagênese, Universidade De Franca, Franca, São Paulo, BrazilCorrespondence[email protected]
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Iara Silva Squarisia Laboratório de Mutagênese, Universidade De Franca, Franca, São Paulo, BrazilORCID Iconhttps://orcid.org/0000-0003-1962-3702View further author information
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Nathália Oliveira Acésioa Laboratório de Mutagênese, Universidade De Franca, Franca, São Paulo, BrazilView further author information
,
Heloiza Diniz Nicolellaa Laboratório de Mutagênese, Universidade De Franca, Franca, São Paulo, BrazilView further author information
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Saulo Duarte Ozelina Laboratório de Mutagênese, Universidade De Franca, Franca, São Paulo, BrazilView further author information
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Matheus Reis Santos de Meloa Laboratório de Mutagênese, Universidade De Franca, Franca, São Paulo, BrazilView further author information
,
Ana Paula Prado Guissonea Laboratório de Mutagênese, Universidade De Franca, Franca, São Paulo, BrazilView further author information
,
Gabriela Fernandesa Laboratório de Mutagênese, Universidade De Franca, Franca, São Paulo, BrazilView further author information
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Lívia Mara Silvab Faculdade De Farmácia, Departamento De Ciências Farmacêuticas, Universidade Federal De Juiz De Fora, Juiz De Fora, Minas Gerais, BrazilView further author information
,
Ademar Alves da Silva Filhob Faculdade De Farmácia, Departamento De Ciências Farmacêuticas, Universidade Federal De Juiz De Fora, Juiz De Fora, Minas Gerais, BrazilView further author information
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Denise Crispim Tavaresa Laboratório de Mutagênese, Universidade De Franca, Franca, São Paulo, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4646-5914View further author information
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Pages 673-686 | Published online: 04 Sep 2020

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Zeynep Betts, Asuman Deveci Ozkan, Burcu Yuksel, Janiah Alimudin, Duygu Aydin, Ozlem Aksoy & Sevinc Yanar. (2023) Investigation of the combined cytotoxicity induced by sodium butyrate and a flavonoid quercetin treatment on MCF-7 breast cancer cells. Journal of Toxicology and Environmental Health, Part A 86:22, pages 833-845.
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Gokul Sudhakaran, Madesh Selvam, A.R. Sreekutty, Abhirami Chandran, Bader O. Almutairi, Selvaraj Arokiyaraj, Pachaiappan Raman, Ajay Guru & Jesu Arockiaraj. (2023) Luteolin photo-protects zebrafish from environmental stressor ultraviolet radiation (UVB). Journal of Toxicology and Environmental Health, Part A 86:19, pages 720-734.
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Jaelson Santos Silva, Éverton Leandro França Ferreira, Amanda Maciel Lima, Ruth Raquel Soares de Farias, Bruno Quirino Araújo, José Carlos Quilles Junior, Rodolfo Ritchelle Lima Santos, Fernando Aécio de Amorim Carvalho, Mahendra Rai, Gerardo Magela Vieira Júnior & Mariana Helena Chaves. (2022) Four new cycloartane-type triterpenoids from the leaves of Combretum mellifluum Eichler: assessment of their antioxidant and antileishmanial activities. Journal of Toxicology and Environmental Health, Part A 85:9, pages 364-375.
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Thaís Teixeira da Silva, Júlia Braga Martins, Maria Do Socorro de Brito Lopes, Pedro Marcos de Almeida, José Luiz Silva Sá & Francielle Alline Martins. (2021) Modulating effect of DL-kavain on the mutagenicity and carcinogenicity induced by doxorubicin in Drosophila melanogaster. Journal of Toxicology and Environmental Health, Part A 84:19, pages 769-782.
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Brian Ogushi Silva, Juliana Botinhon Orlando, Camila Lehnhardt Pires, Clélia Akiko Hiruma-Lima, Isabel de Mascarenhas Gaivão, Fábio Ferreira Perazzo & Edson Luis Maistro. (2021) Genotoxicity induced by nerol, an essential oil present in citric plants using human peripheral blood mononuclear cells (PBMC) and HepG2/C3A cells as a model. Journal of Toxicology and Environmental Health, Part A 84:12, pages 518-528.
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Vivianne Rodrigues Amorim, Débora Caroline do Nascimento Rodrigues, Jurandy do Nascimento Silva, Carla Lorena Silva Ramos, Lívia Maria Nunes Almeida, Antonia Amanda Cardoso Almeida, Flaviano Ribeiro Pinheiro-Neto, Fernanda Regina Castro Almeida, Marcia Santos Rizzo, Joilane Alves Pereira-Freire & Paulo Michel Pinheiro Ferreira. (2021) Anti-inflammatory mechanisms of fruits and by-products from Mauritia flexuosa, an exotic plant with functional benefits#. Journal of Toxicology and Environmental Health, Part A 84:11, pages 441-457.
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Articles from other publishers (17)

Iffat Ara, Rita Turcio, Tasmia Islam, Md. Sabbir Hossain & Md. Kamrul Hasan. (2023) Anti-aging related activities and health benefits of Licochalcone A: A review. Clinical Complementary Medicine and Pharmacology, pages 100125.
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Yi Hu, Peiyi Liang, Zhuxian Wang, CuiPing Jiang, Yinglin Guo, Hongkai Chen, Chunyan Shen, Yufan Wu, Li Liu, Yankui Yi, Qiang Liu & Hongxia Zhu. (2023) Exploring the Molecular Mechanism of the Antioxidant Activity of Medicine and Food Homology Licorice Flavonoids Based on Pharmacophore Theory and Quantum Calculations. Journal of Food Biochemistry 2023, pages 1-16.
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Xiaoli Fan, Guoqiang Guan, Juan Wang, Meihua Jin, Liming Wang & Xiaoqun Duan. (2023) Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer. Oncology Reports 50:6.
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Jian-Hong Lin, Kun-Ta Yang, Pei-Ching Ting, Wen-Sen Lee, Ding-Jyun Lin & Jui-Chih Chang. (2023) Licochalcone a improves cardiac functions after ischemia-reperfusion via reduction of ferroptosis in rats. European Journal of Pharmacology 957, pages 176031.
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Jun Wang, Xiuxiu Zhang, Zhijing Ni, Elnur Elam, Kiran Thakur, Kexin Li, Chuyan Wang, Jianguo Zhang & Zhaojun Wei. (2023) The anti-cancerous mechanism of licochalcone A on human hepatoma cell HepG2 based on the miRNA omics. Food Science and Human Wellness 12:4, pages 1136-1148.
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Noel Joseph J., Akansha Shrivastava, Bitto Benny, Mohamed Yusuf Baig, Ann Georgine S. & Mary Saral A.. (2023) Antiviral Properties of Various Bioactive Components Present in the Root of Glycyrrhiza glabra: Review. Current Nutrition & Food Science 19:2, pages 166-175.
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Jin-Xin Zhang, Yan Xiao, Yi-Quan Li, Yi-Long Zhu, Ya-Ru Li, Ren-Shuang Zhao, Ning-Yi Jin, Jin-Bo Fang, Xiao Li & Ji-Cheng Han. (2023) Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway. Integrative Cancer Therapies 22.
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Maoyuan Zhao, Feng Wei, Guangwei Sun, Yueqiang Wen, Juyi Xiang, Fangting Su, Lu Zhan, Qing Nian, Yu Chen & Jinhao Zeng. (2022) Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review. Frontiers in Pharmacology 13.
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Karoline Soares de Freitas, Lucas Henrique Domingos da Silva, Iara Silva Squarisi, Lucas Teixeira de Souza Oliveira, Arthur Barcelos Ribeiro, Bianca Silva Alves, Tábata Rodrigues Esperandim, Matheus Reis Santos de Melo, Saulo Duarte Ozelin, Danieli Cristina Lemes, Jairo Kenupp Bastos, Rodrigo Cassio Sola Veneziani & Denise Crispim Tavares. (2022) Red propolis exhibits chemopreventive effect associated with antiproliferative and anti-inflammatory activities. Toxicology Research 11:5, pages 750-757.
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Lu Shi, Yiying Zhao, Chenran Feng, Feng Miao, Linlin Dong, Tianquan Wang, Antony Stalin, Jingyuan Zhang, Jingru Tu, Kexin Liu, Wenyan Sun & Jiarui Wu. (2022) Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: Network pharmacology and experimental validation. Frontiers in Pharmacology 13.
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Tonancy Nicolás-Méndez, Sam Kacew, Alda Rocío Ortiz-Muñiz, Víctor Manuel Mendoza-Núñez & María del Carmen García-Rodríguez. (2022) Protective Effect of Resveratrol against Hexavalent Chromium-Induced Genotoxic Damage in Hsd:ICR Male Mice. Molecules 27:13, pages 4028.
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Yuhang Yang, Zhongan Zhu, Michael Adu-Frimpong, Jing Liu, Yaping Wang, Lin Chen, Elmurat Toreniyazov, Hao Ji, Xia Cao, Feng Shi, Qilong Wang, Jiangnan Yu & Ximing Xu. (2022) Micelles of Licorice chalcone A for oral administration: preparation, in vitro, in vivo, and hepatoprotective activity evaluation. Journal of Nanoparticle Research 24:6.
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Yuxuan Han, Zhuoni Hou, Xuemin Zhang, Qiuling He & Zongsuo Liang. (2022) Multi-dimensional "projection" - the impact of abiotic stresses on the content of seven active compounds and expression of related genes in Glycyrrhiza uralensis Fisch. Environmental and Experimental Botany 197, pages 104846.
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Wenfeng Wu, Zhuxian Wang, Yufan Wu, Huiyi Wu, Tingting Chen, Yaqi Xue, Yuan Wang, Cuiping Jiang, Chunyan Shen, Li Liu, Hongxia Zhu & Qiang Liu. (2022) Mechanisms of Penetration Enhancement and Transport Utilizing Skin Keratine Liposomes for the Topical Delivery of Licochalcone A. Molecules 27:8, pages 2504.
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Ruth Galindo, Elena Sánchez-López, María José Gómara, Marta Espina, Miren Ettcheto, Amanda Cano, Isabel Haro, Antoni Camins & María Luisa García. (2022) Development of Peptide Targeted PLGA-PEGylated Nanoparticles Loading Licochalcone-A for Ocular Inflammation. Pharmaceutics 14:2, pages 285.
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Baosheng Zhou, Honglin Wang, Bo Zhang & Lianlian Zhang. (2021) Licochalcone B attenuates neuronal injury through anti-oxidant effect and enhancement of Nrf2 pathway in MCAO rat model of stroke. International Immunopharmacology 100, pages 108073.
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Zhuoyin Xue, Yongjing Zhang, Yingnan Zeng, Shiling Hu, Haoyun Bai, Jue Wang, Huiling Jing & Nan Wang. (2021) Licochalcone A inhibits MAS ‐related GPR family member X2 ‐induced pseudo‐allergic reaction by suppressing nuclear migration of nuclear factor‐κB . Phytotherapy Research 35:11, pages 6270-6280.
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