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Journal of Toxicology and Environmental Health Volume 13, 1984 - Issue 1
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Original Articles

The effect of phenobarbital pretreatment on the metabolism, covalent binding, and cytotoxicity of aflatoxin B1 in primary cultures of rat hepatocytes

David J. Loury Department of Environmental Toxicology, University of California, Davis, California, 95616
,
Dennis P. H. Hsieh Department of Environmental Toxicology, University of California, Davis, California
&
James L. Byard Department of Environmental Toxicology, University of California, Davis, California
Pages 145-159 | Received 18 May 1983, Accepted 14 Sep 1983, Published online: 19 Oct 2009

Citations (16)

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Maxine Warren & Jeffrey R. Fry. (1988) Influence of medium composition on 7-alkoxycoumarin O-dealkylase activities of rat hepatocytes in primary maintenance culture. Xenobiotica 18:8, pages 973-981.
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C. J. Holeski, D. L. Eaton, D. H. Monroe & G. M. Bellamy. (1987) Effects of phenobarbital on the biliary excretion of aflatoxin P 1-glucuronide and aflatoxin B1-S-glutathione in the rat. Xenobiotica 17:2, pages 139-153.
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Articles from other publishers (14)

J.C. Phillips, S. Davies & B.G. Lake. (1999) Dose-response relationships for hepatic aflatoxin B1-DNA adduct formation in the rat in vivo and in vitro: The use of immunoslot blotting for adduct quantitation. Teratogenesis, Carcinogenesis, and Mutagenesis 19:2, pages 157-170.
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John D. Hayes, David J. Judah, Lesley I. McLellan & Gordon E. Neal. (1991) Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1. Pharmacology & Therapeutics 50:3, pages 443-472.
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David L. Eaton, Howard Ramsdell & David H. Monroe. 1990. Microbial Toxins in Foods and Feeds. Microbial Toxins in Foods and Feeds 275 290 .
Suzanne Hendrich, Howard P. Glauert & Henry C. Pitot. (1988) Dietary effects on initiation and promotion of hepatocarcinogenesis in rat. Journal of Cancer Research and Clinical Oncology 114:2, pages 149-157.
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John R. MacDonald, Kristine J. Thayer & Edward A. Smuckler. (1987) Isolation and maintenance of monolayer hepatocytes from the livers of toxin-treated rats. Experimental and Molecular Pathology 46:1, pages 64-77.
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D.H. Monroe, C.J. Holeski & D.L. Eaton. (1986) Effects of single-dose and repeated-dose pretreatment with 2(3)-tert-butyl-4-hydroxyanisole (BHA) on the hepatobiliary disposition and covalent binding to DNA of aflatoxin B1 in the rat. Food and Chemical Toxicology 24:12, pages 1273-1281.
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S. Hendrich & L.F. Bjeldanes. (1986) Effects of Dietary Schizandra chinensis, Brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver. Food and Chemical Toxicology 24:9, pages 902-912.
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Malcolm A. Moore & Tomoyuki Kitagawa. 1986. 125 173 .
Elisabeth Madle, Gudrun Tiedemann, Stephan Madle, Angelika Ott & Gabriele Kaufmann. (2006) Comparison of S9 mix and hepatocytes as external metabolizing systems in Mammalian cell cultures: Cytogenetic effects of 7,12‐dimethylbenzanthracene and aflatoxin B1. Environmental Mutagenesis 8:3, pages 423-437.
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C.I. Wei & D.P.H. Hsieh. (1985) Characterization of water-soluble glucuronide and sulphate conjugates of aflatoxin B1. 2. Studies in primary cultures of rat hepatocytes. Food and Chemical Toxicology 23:9, pages 821-825.
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C.I. Wei, M.R. Marshall & D.P.H. Hsieh. (1985) Characterization of water-soluble glucuronide and sulphate conjugates of aflatoxin B1. 1. Urinary excretion in monkey, rat and mouse. Food and Chemical Toxicology 23:9, pages 809-819.
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M.A. Hayes & D.B. Pickering. (1985) Comparative cytopathology of primary rat hepatocyte cultures exposed to aflatoxin B1, acetaminophen, and other hepatotoxins. Toxicology and Applied Pharmacology 80:2, pages 345-356.
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James L. Byard & Kathleen K. Dougherty. (1985) Comparative metabolism and toxicity of chemical carcinogens in primary cultures of hepatocytes. In Vitro Cellular & Developmental Biology 21:9, pages 489-494.
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M.Y. Fukayama & D.P.H. Hsieh. (1985) Effect of butylated hydroxytoluene pretreatment on the excretion, tissue distribution and DNA binding of [14C]aflatoxin B1 in the rat. Food and Chemical Toxicology 23:6, pages 567-573.
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