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Original Articles

Quercetin: A mutagen, not a carcinogen, in fischer rats

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Pages 105-114 | Received 15 Apr 1983, Accepted 17 Oct 1983, Published online: 20 Oct 2009

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Luyi Ye, Xiaolin Wang, Tomonobu Konno, Xiangyu Gong, Hao Ding, Hua Yan, Zai-Si Ji & Enuo Liu. (2022) Fat reducing effects of Nelumbo nucifera leaf extract in overweight patients. Natural Product Research 36:18, pages 4770-4775.
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PO-CHUEN CHAN, QINGSU XIA & PETERP. FU. (2007) Ginkgo Biloba Leave Extract: Biological, Medicinal, and Toxicological Effects. Journal of Environmental Science and Health, Part C 25:3, pages 211-244.
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Catherine Chaumontet, Marc Suschetet, Esther Honikman‐Leban, VladimirA. Krutovskikh, Raymond Berges, Anne‐Marie Le Bon, Christine Heberden, MajdiM. Shahin, Hiroshi Yamasaki & Paule Martel. (1996) Lack of tumor‐promoting effects of flavonoids: Studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. Nutrition and Cancer 26:3, pages 251-263.
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SauraC. Sahu. (1994) Dual role of flavonoids in mutagenesis and carcinogenesis. Journal of Environmental Science and Health, Part C 12:1, pages 1-21.
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Larry Fluss, Tai Nguyen, Charles Ginther & Terrance Leighton. (1990) Reduction in the direct‐acting mutagenic activity of red wine by treatment with polyvinylpolypyrrolidone. Journal of Wine Research 1:1, pages 35-43.
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Articles from other publishers (45)

Ankit Tripathi, Manoj Kumar, Punit Kaur, Bhuvnesh Kumar & Sarada S.K. Sagi. (2020) Efficacy of Quercetin as a potent sensitizer of β2-AR in combating the impairment of fluid clearance in lungs of rats under hypoxia. Respiratory Physiology & Neurobiology 273, pages 103334.
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Michael T. Murray. 2020. Textbook of Natural Medicine. Textbook of Natural Medicine 613 619.e2 .
Haiping Zhang, Linbu Liao, Yunting Cai, Yuhui Hu & Hao Wang. (2019) IVS2vec: A tool of Inverse Virtual Screening based on word2vec and deep learning techniques. Methods 166, pages 57-65.
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Susanne Andres, Sophie Pevny, Rainer Ziegenhagen, Nadiya Bakhiya, Bernd Schäfer, Karen Ildico Hirsch-Ernst & Alfonso Lampen. (2018) Safety Aspects of the Use of Quercetin as a Dietary Supplement. Molecular Nutrition & Food Research 62:1, pages 1700447.
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Dharambir Kashyap, Sonam Mittal, Katrin Sak, Paavan Singhal & Hardeep Singh Tuli. (2016) Molecular mechanisms of action of quercetin in cancer: recent advances. Tumor Biology 37:10, pages 12927-12939.
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Elise F. Hoek-van den Hil, Evert M. van Schothorst, Inge van der Stelt, Peter C.H. Hollman, Jaap Keijer & Ivonne M.C.M. Rietjens. (2015) Quercetin tests negative for genotoxicity in transcriptome analyses of liver and small intestine of mice. Food and Chemical Toxicology 81, pages 34-39.
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Ezzeldeen S. El-Denshary, Abdulhadi Aljawish, Aziza A. El-Nekeety, Nabila S. Hassan, Raghda H. Saleh, Bertrand H. Rihn & Mosaad A. Abdel-Wahhab. (2015) Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats. Soft Nanoscience Letters 05:02, pages 36-51.
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Shin Sato, Yuuka Mukai & Takeshi Saito. (2013) Quercetin intake during lactation modulates the AMP-activated protein kinase pathway in the livers of adult male rat offspring programmed by maternal protein restriction. The Journal of Nutritional Biochemistry 24:1, pages 118-123.
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Michael T. Murray. 2013. Textbook of Natural Medicine. Textbook of Natural Medicine 772 779 .
Hassan H. Abdallah, Janez Mavri, Matej Repič, Vannajan Sanghiran Lee & Habibah A. Wahab. (2012) Chemical Reaction of Soybean Flavonoids with DNA: A Computational Study Using the Implicit Solvent Model. International Journal of Molecular Sciences 13:2, pages 1269-1283.
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Evi Juwita Salim & Suryani Hartati Oetojo. (2011) Psycho-evolutionary computing: Artificial intelligence: Bio-informatics. Psycho-evolutionary computing: Artificial intelligence: Bio-informatics.
Xiao-Li Liu, Hong-Fang Zhang, Guang-Jun Qiao, Wei Cao & Jian-Bin Zheng. (2008) Determination of Apigenin by LC with Electrochemical Detection. Chromatographia 68:1-2, pages 147-150.
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D. Utesch, K. Feige, J. Dasenbrock, T.H. Broschard, M. Harwood, B. Danielewska-Nikiel & T.C. Lines. (2008) Evaluation of the potential in vivo genotoxicity of quercetin. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 654:1, pages 38-44.
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M. Harwood, B. Danielewska-Nikiel, J.F. Borzelleca, G.W. Flamm, G.M. Williams & T.C. Lines. (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food and Chemical Toxicology 45:11, pages 2179-2205.
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Je-Hyuk Lee, Hong Yu Zhou, So Yean Cho, Yeong Shik Kim, Yong Soo Lee & Choon Sik Jeong. (2007) Anti-inflammatory mechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules. Archives of Pharmacal Research 30:10, pages 1318-1327.
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J. Tieppo, R. Vercelino, A.S. Dias, M.F. Silva Vaz, T.R. Silveira, C.A. Marroni, N.P. Marroni, J.A.P. Henriques & J.N. Picada. (2007) Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome. Food and Chemical Toxicology 45:7, pages 1140-1146.
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Gordon C. Hard, John Curtis Seely, Laura J. Betz & Shim-mo Hayashi. (2007) Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Food and Chemical Toxicology 45:4, pages 600-608.
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Johannes Westendorf, Katharina Effenberger, Hassan Iznaguen & Simla Basar. (2006) Toxicological and Analytical Investigations of Noni ( Morinda citrifolia ) Fruit Juice . Journal of Agricultural and Food Chemistry 55:2, pages 529-537.
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H. Stopper, E. Schmitt & K. Kobras. (2005) Genotoxicity of phytoestrogens. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 574:1-2, pages 139-155.
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Ivonne M.C.M. Rietjens, Marelle G. Boersma, Hester van der Woude, Suzanne M.F. Jeurissen, Maaike E. Schutte & Gerrit M. Alink. (2005) Flavonoids and alkenylbenzenes: Mechanisms of mutagenic action and carcinogenic risk. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 574:1-2, pages 124-138.
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Hiroki Sakai, Tetsuya Tsukamoto, Masami Yamamoto, Kiyoshi Kobayashi, Hirofumi Yuasa, Toshio Imai, Tokuma Yanai, Toshiaki Masegi & Masae Tatematsu. (2002) Distinction of carcinogens from mutagens by induction of liver cell foci in a model for detection of initiation activity. Cancer Letters 188:1-2, pages 33-38.
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Ivonne M.C.M. Rietjens, Marelle G. Boersma, Laura de Haan, Bert Spenkelink, Hanem M. Awad, Nicole H.P. Cnubben, Jelmer J. van Zanden, Hester van der Woude, Gerrit M. Alink & Jan H. Koeman. (2002) The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids. Environmental Toxicology and Pharmacology 11:3-4, pages 321-333.
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J da Silva, S.M Herrmann, V Heuser, W Peres, N Possa Marroni, J González-Gallego & B Erdtmann. (2002) Evaluation of the genotoxic effect of rutin and quercetin by comet assay and micronucleus test. Food and Chemical Toxicology 40:7, pages 941-947.
Crossref
B Delaney, K Phillips, C Vasquez, A Wilson, D Cox, H-B Wang & J Manthey. (2002) Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. Food and Chemical Toxicology 40:5, pages 617-624.
Crossref
Miguel. E. Alonso-Amelot. 2002. Bioactive Natural Products. Bioactive Natural Products 685 739 .
Dennis A Ricupero, Christine F Poliks, David C Rishikof, Ping-Ping Kuang & Ronald H Goldstein. (2001) Apigenin decreases expression of the myofibroblast phenotype. FEBS Letters 506:1, pages 15-21.
Crossref
V�ronique Trochon, Emmanuel Blot, Florence Cymbalista, Carsten Engelmann, Ruo-Ping Tang, Annick Thoma�dis, Marc Vasse, Jeannette Soria, He Lu & Claudine Soria. (2000) Apigenin inhibits endothelial-cell proliferation in G2/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. International Journal of Cancer 85:5, pages 691-696.
Crossref
Mahmood Shahin, Barry L Smith & Arungundrum S Prakash. (1999) Bracken carcinogens in the human diet. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 443:1-2, pages 69-79.
Crossref
D.D. Schramm, H.E. Collins, R.S. Hawley & J.B. German. (1998) Unaltered Meiotic Chromosome Segregation in Drosophila melanogaster Raised on a 5% Quercetin Diet. Food and Chemical Toxicology 36:7, pages 585-589.
Crossref
G. Eisenbrand & W. Tang. 1997. Phytopharmaka III. Phytopharmaka III 3 16 .
J.V. Formica & W. Regelson. (1995) Review of the biology of quercetin and related bioflavonoids. Food and Chemical Toxicology 33:12, pages 1061-1080.
Crossref
Barry L. Smith & Alan A. Seawright. (2006) Bracken fern ( Pteridium spp.) carcinogenicity and human health—a brief review . Natural Toxins 3:1, pages 1-5.
Crossref
Elliott MiddletonJr.Jr. & Chithan Kandaswami. 1994. The Flavonoids. The Flavonoids 619 652 .
Dagny Sandnes, Toril Johansen, Gerd Teien & Gunnar Ulsaker. (2009) Mutagenicity of Crude Senna and Senna Glycosides in Salmonella typhimurium . Pharmacology & Toxicology 71:3, pages 165-172.
Crossref
Weici Tang & Gerhard EisenbrandWeici Tang & Gerhard Eisenbrand. 1992. Chinese Drugs of Plant Origin. Chinese Drugs of Plant Origin 945 955 .
Saura C. Sahu & Melissa C. Washington. (1991) Effects of antioxidants on quercetin-induced nuclear DNA damage and lipid peroxidation. Cancer Letters 60:3, pages 259-264.
Crossref
Satoshi Suzuki, Toshinori Takada, Yoshiko Sugawara, Terukazu Muto & Ryo Ryo. (1991) Quercetin Induces Recombinational Mutations in Cultured Cells as Detected by DNA Fingerprinting. Japanese Journal of Cancer Research 82:10, pages 1061-1064.
Crossref
S.C. Sahu & M.C. Washington. (1991) Quercetin-induced lipid peroxidation and DNa damage in isolated rat-liver nuclei. Cancer Letters 58:1-2, pages 75-79.
Crossref
Mitsumori Yoshida, Toshiyuki Sakai, Nobuko Hosokawa, Nobuyuki Marui, Katsuhiko Matsumoto, Akihiro Fujioka, Hoyoku Nishino & Akira Aoike. (1990) The effect of quercetin on cell cycle progression and growth of human gastric cancer cells. FEBS Letters 260:1, pages 10-13.
Crossref
Y. Kurata, S. Fukushima, A. Hagiwara, H. Ito, K. Ogawa & N. Ito. (1990) Carcinogenicity study of methyl hesperidin in B6C3F1 mice. Food and Chemical Toxicology 28:9, pages 613-618.
Crossref
Nobuyuki Ito, Akihiro Hagiwara, Seiko Tamano, Masataka Kagawa, Masa‐Aki Shibata, Yasushi Kurata & Shoji Fukushima. (2005) Lack of Carcinogenicity of Quercetin in F344/DuCrj Rats. Japanese Journal of Cancer Research 80:4, pages 317-325.
Crossref
Nobuyuki Ito & Masao Hirose. 1989. 247 302 .
JOSEPH P. BROWN. 1988. Role of the Gut Flora in Toxicity and Cancer. Role of the Gut Flora in Toxicity and Cancer 109 144 .
YIN-TAK WOO, DAVID Y. LAI, JOSEPH C. ARCOS & MARY F. ARGUS. 1988. Natural, Metal, Fiber, and Macromolecular Carcinogens. Natural, Metal, Fiber, and Macromolecular Carcinogens 3 616 .
David B. Couch, Earl Stuart & John A. Heddle. (2006) Effect of oral administration of mutagens found in food on the frequency of sister chromatid exchanges in the colonic epithelium of mice. Environmental and Molecular Mutagenesis 10:2, pages 205-209.
Crossref

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