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Journal of Toxicology and Environmental Health Volume 14, 1984 - Issue 5-6
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Original Articles

Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes

M. A. Hayes Department of Pathology, University of Guelph, Guelph, Ontario, Canada, N1G 2W1; Department of Pathology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
,
E. Roberts Department of Pathology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
,
M. V. Jago Division of Animal Health, CSIRO, Parkville, Victoria, Australia
,
S. H. Safe Department of Veterinary Physiology and Pharmacology, Texas A & M University, College Station, Texas
,
E. Farber Department of Pathology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
&
R. C. Cameron Department of Pathology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
Pages 683-694 | Received 14 May 1984, Accepted 03 Jul 1984, Published online: 20 Oct 2009

Citations (7)

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Read on this site (2)

Peter P. Fu, Qingsu Xia, Ge Lin & Ming W. Chou. (2004) Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms. Drug Metabolism Reviews 36:1, pages 1-55.
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J. C. Merrill, H. L. Kim, S. Safe, C. A. Murray & M. A. Hayes. (1988) Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. Journal of Toxicology and Environmental Health 23:2, pages 159-169.
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Articles from other publishers (5)

Lu Chen, Jia Ning, Jochem Louisse, Sebas Wesseling & Ivonne M.C.M. Rietjens. (2018) Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat. Food and Chemical Toxicology 116, pages 216-226.
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Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara & Masao Hattori. (2007) In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis , by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors . Drug Metabolism and Disposition 35:10, pages 1832-1839.
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David J. Moore, Kenneth P. Batts, Leon L. Zalkow, G.Thomas FortuneJr.Jr. & Garth Powis. (1989) Model systems for detecting the hepatic toxicity of pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides. Toxicology and Applied Pharmacology 101:2, pages 271-284.
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Edward W.Y. Koo, M. Anthony Hayes, Michael K.K. Wong & Avrum I. Gotlieb. (1987) Aflatoxin B1 and acetaminophen induce different cytoskeletal responses during prelethal hepatocyte injury. Experimental and Molecular Pathology 47:1, pages 37-47.
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M.A. Hayes & D.B. Pickering. (1985) Comparative cytopathology of primary rat hepatocyte cultures exposed to aflatoxin B1, acetaminophen, and other hepatotoxins. Toxicology and Applied Pharmacology 80:2, pages 345-356.
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