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Journal of Toxicology and Environmental Health Volume 18, 1986 - Issue 3
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Original Articles

Carcinogenesis studies of 4,4'‐methylenedianiline dihydrochloride given in drinking water to F344/N rats and B6C3F1 mice

J. C. Lamb National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; National Institute of Environmental Health Sciences, Office of Pesticides and Toxic Substances (TS‐788), 401 M St., S.W., Washington, D.C., 20460
,
J. E. Huff National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
,
J. K. Haseman National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
,
A. S. K. Murthy E.G. & G. Mason Research Institute, Worcester, Massachusetts
&
H. Lilja E.G. & G. Mason Research Institute, Worcester, Massachusetts
Pages 325-337 | Received 04 Apr 1985, Accepted 31 Jan 1986, Published online: 20 Oct 2009

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Claudia Bolognesi, Xaver Baur, Boleslaw Marczynski, Hannu Norppa, Ovnair Sepai & Gabriele Sabbioni. (2001) Carcinogenic Risk of Toluene Diisocyanate and 4,4′-Methylenediphenyl Diisocyanate: Epidemiological and Experimental Evidence. Critical Reviews in Toxicology 31:6, pages 737-772.
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M. Peel, B. Marczynski & X. Baur. (1997) COMPARISON OF THE BINDING POTENTIAL OF VARIOUS DIISOCYANATES ON DNA IN VITRO. Journal of Toxicology and Environmental Health 52:6, pages 517-526.
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Hans L. Tillmann, Frank N.A.M. Van Pelt, Walter Martz, Thomas Luecke, Hartmut Welp, Frauke Dörries, Ansgar Veuskens, Martin Fischer & Michael P. Manns. (1997) Accidental Intoxication with Methylene Dianiline p, p′-Diaminodiphenylmethane: Acute Liver Damage After Presumed Ecstasy Consumption. Journal of Toxicology: Clinical Toxicology 35:1, pages 35-40.
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Nobuyuki Ito, Ryohei Hasegawa, Katsumi Imaida, Satoru Takahashi & Tomoyuki Shirai. (1994) Medium-Term Rat Liver Bioassay for Rapid Detection of Carcinogens and Modifiers of Hepatocarcinogenesis. Drug Metabolism Reviews 26:1-2, pages 431-442.
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K. Wu, C. L. Leslie & N. H. Stacey. (1989) Effects of mutagenic and non-mutagenic aniline derivatives on rat liver drug-metabolizing enzymes. Xenobiotica 19:11, pages 1275-1283.
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Articles from other publishers (29)

Elif Unterberger-Henig. (2022) Comparative evaluation of three methylene dianiline isomers in the bacterial reverse mutation assay, the in vitro gene mutation test, and the in vitro chromosomal aberration test. Toxicology and Industrial Health 38:9, pages 529-543.
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Sonia Stoica, George E. Magoulas, Antonia I. Antoniou, Sherif Suleiman, Analisse Cassar, Lucienne Gatt, Dionissios Papaioannou, Constantinos M. Athanassopoulos & Pierre Schembri-Wismayer. (2016) Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents. Bioorganic & Medicinal Chemistry Letters 26:4, pages 1145-1150.
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HIDEHARU SHINTANI. (2015) Formation and Elution of Toxic Compounds From γ-Ray-Sterilized Medical Products and the Ames Test of Eluted Components. Biocontrol Science 20:2, pages 135-145.
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Yuta Ozawa & Mitsuhiro Shibata. (2014) Biobased thermosetting resins composed of L -lysine methyl ester and bismaleimide . Journal of Applied Polymer Science 131:12, pages n/a-n/a.
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Klaus-Peter Wilhelm, Hongbo Zhai & Howard I. MaibachGermaine L. Truisi, Howard I. Maibach & Philip G. Hewitt. 2012. Dermatotoxicology. Dermatotoxicology 43 57 .
Chinnu Sugavanam Senthilkumar, Nand Kishore Sah & Narayanan Ganesh. (2012) Methyl Isocyanate and Carcinogenesis: Bridgeable Gaps in Scientific Knowledge. Asian Pacific Journal of Cancer Prevention 13:6, pages 2429-2435.
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 38 57 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 15 .
Olga GioulemeSofia Karabatsou, Prodromos Hytiroglou, Andreas Xanthis, Eleni Tsiaousi, Marios Katsaros & Dimitrios Koliouskas. (2010) 4,4′-Methylenedianiline-induced hepatitis in an industrial worker: Case report and review of the literature. Human & Experimental Toxicology 30:7, pages 762-767.
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Kan Chen, Richard B. Cole, Vicente Santa Cruz, Ernest W. Blakeney, Mary F. Kanz & Tammy R. Dugas. (2008) Characterization of biliary conjugates of 4,4′-methylenedianiline in male versus female rats. Toxicology and Applied Pharmacology 232:2, pages 190-202.
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Heidrun Ellinger-Ziegelbauer, Hans Gmuender, Arnd Bandenburg & Hans Juergen Ahr. (2008) Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 637:1-2, pages 23-39.
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Xiaoyan Zhang, Jason C. Lambert, Mark A. Doll, Jason M. Walraven, Gavin E. Arteel & David W. Hein. (2006) 4,4′-Methylenedianiline-Induced Hepatotoxicity Is Modified by N -Acetyltransferase 2 (NAT2) Acetylator Polymorphism in the Rat . Journal of Pharmacology and Experimental Therapeutics 316:1, pages 289-294.
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Susan H. Kenyon, Joya Bhattacharyya, Christopher J. Benson & Paul L. Carmichael. (2004) Percutaneous penetration and genotoxicity of 4,4′-methylenedianiline through rat and human skin in vitro. Toxicology 196:1-2, pages 65-75.
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P. Hewitt & H. I. Maibach. 2004. Condensed Handbook of Occupational Dermatology. Condensed Handbook of Occupational Dermatology 21 36 .
P. Hewitt & H. I. Maibach. 2000. Handbook of Occupational Dermatology. Handbook of Occupational Dermatology 43 55 .
Hideharu Shintani. (1996) Formation and elution of toxic compounds from sterilized medical products: Toxic compound formation from irradiated products. Radiation Physics and Chemistry 47:1, pages 139-148.
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James E. Heath. 1996. Endocrine System. Endocrine System 254 261 .
Hideharu Shintani. (2016) Formation and Elution of Toxic Compounds from Sterilized Medical Products: Methylenedianiline Formation in Polyurethane. Journal of Biomaterials Applications 10:1, pages 23-58.
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Mary F. Kanz, Aixia Wang & Gerald A. Campbell. (1995) Infusion of bile from methylene dianiline-treated rats into the common bile duct injures biliary epithelial cells of recipient rats. Toxicology Letters 78:2, pages 165-171.
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Esther H. Vock, Sergio Cantoreggi, Ramesh C. Gupta & Werner K. Lutz. (1995) 32P-postlabeling analysis of DNA adducts formed in vitro and in rat skin by methylenediphenyl-4,4'-diisocyanate (MDI). Toxicology Letters 76:1, pages 17-26.
Crossref
Gary M. Liss & Sam S. Guirguis. (2007) Follow‐up of a group of workers intoxicated with 4,4′‐methylenedianiline. American Journal of Industrial Medicine 26:1, pages 117-124.
Crossref
S.A.M. Hotchkiss, P. Hewitt & J. Caldwell. (1993) Percutaneous absorption of 4,4′-methylene-bis(2-chloroaniline) and 4,4′-methylenedianiline through rat and human skin in vitro. Toxicology in Vitro 7:2, pages 141-148.
Crossref
R. Hasegawa & N. Ito. (1992) Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. Food and Chemical Toxicology 30:11, pages 979-992.
Crossref
Mary F. Kanz, Lata Kaphalia, Bhupendra S. Kaphalia, Eleonora Romagnoli & G.A.S. Ansari. (1992) Methylene dianiline: Acute toxicity and effects on biliary function. Toxicology and Applied Pharmacology 117:1, pages 88-97.
Crossref
Hideharu Shintani & Akitada Nakamura. (2004) Formation of 4,4′‐methylenedianiline in polyurethane potting materials by either γ‐ray or autoclave sterilization. Journal of Biomedical Materials Research 25:10, pages 1275-1286.
Crossref
E. Bailey, A.G. Brooks, I. Bird, P.B. Farmer & B. Street. (1990) Monitoring exposure to 4,4′-methylenedianiline by the gas chromatography-mass spectrometry determination of adducts to hemoglobin. Analytical Biochemistry 190:2, pages 175-181.
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P. B. Farmer & E. Bailey. 1989. Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances. Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances 83 90 .
Nobuyuki Ito, Hiroyuki Tsuda, Ryohei Hasegawa, Masae Tatematsu, Katsumi Imaida & Makoto Asamoto. 1989. Biologically Based Methods for Cancer Risk Assessment. Biologically Based Methods for Cancer Risk Assessment 209 230 .
John Cocker, Alan R. Boobis & Donald S. Davies. (1988) Determination of theN-acetyl metabolites of 4,4′-methylene dianiline and 4,4′-methylene-bis(2-chloroaniline) in urine. Biological Mass Spectrometry 17:3, pages 161-167.
Crossref

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