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Original Articles

Disposition of 2‐hydroxy‐4‐methoxybenzophenone in rats dosed orally, intravenously, or topically

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Pages 491-502 | Received 31 Mar 1986, Accepted 27 May 1986, Published online: 20 Oct 2009

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Esra Mutlu, C. Edwin Garner, Christopher J. Wegerski, Jacob D. McDonald, Barry S. McIntyre, Melanie Doyle-Eisele & Suramya Waidyanatha. (2020) Metabolism and disposition of 2-hydroxy-4-methoxybenzophenone, a sunscreen ingredient, in Harlan Sprague Dawley rats and B6C3F1/N mice; a species and route comparison . Xenobiotica 50:6, pages 689-704.
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Maria Eugenia Sesto Cabral, Alberto Nicolas Ramos, Carla Agostina Cabrera, Juan Carlos Valdez & Silvia Nelina González. (2015) Equipment and method for in vitro release measurements on topical dosage forms. Pharmaceutical Development and Technology 20:5, pages 619-625.
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Nagisa Kamikyouden, Kazumi Sugihara, Yoko Watanabe, Naoto Uramaru, Tsuyoshi Murahashi, Masanori Kuroyanagi, Seigo Sanoh, Shigeru Ohta & Shigeyuki Kitamura. (2013) 2,5-Dihydroxy-4-methoxybenzophenone: a novel major in vitro metabolite of benzophenone-3 formed by rat and human liver microsomes. Xenobiotica 43:6, pages 514-519.
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Articles from other publishers (23)

Vicente Mustieles, Ria K. Balogh, Marta Axelstad, Parisa Montazeri, Sandra Márquez, Martine Vrijheid, Monica K. Draskau, Camilla Taxvig, Francisco M. Peinado, Tamar Berman, Hanne Frederiksen, Mariana F. Fernández, Anne Marie Vinggaard & Anna-Maria Andersson. (2023) Benzophenone-3: Comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies. Environment International 173, pages 107739.
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Woohyung Jung, Su Hyun Seok, Soyoung Shin, Sung Ha Ryu, Kyu-Bong Kim, Beom Soo Shin & Tae Hwan Kim. (2022) Toxicokinetics, Percutaneous Absorption and Tissue Distribution of Benzophenone-3, an UV Filtering Agent, in Rats. Toxics 10:11, pages 672.
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Nick Serpone. (2021) Sunscreens and their usefulness: have we made any progress in the last two decades?. Photochemical & Photobiological Sciences 20:2, pages 189-244.
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Esra Mutlu, Jessica Pierfelice, Barry S McIntyre, Helen C Cunny, Grace E Kissling, Brian Burback & Suramya Waidyanatha. (2017) Simultaneous Quantitation of 2-Hydroxy-4-Methoxybenzophenone, a Sunscreen Ingredient, and its Metabolites in Harlan Sprague Dawley Rat Plasma Following Perinatal Dietary Exposure. Journal of Analytical Toxicology 41:9, pages 744-754.
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Joanna A. Ruszkiewicz, Adi Pinkas, Beatriz Ferrer, Tanara V. Peres, Aristides Tsatsakis & Michael Aschner. (2017) Neurotoxic effect of active ingredients in sunscreen products, a contemporary review. Toxicology Reports 4, pages 245-259.
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Noriko Nakamura, Amy L. Inselman, Gene A. White, Ching-Wei Chang, Raul A. Trbojevich, Estatira Sephr, Kristie L. Voris, Ralph E. Patton, Matthew S. Bryant, Wafa Harrouk, Barry S. McIntyre, Paul M.D. Foster & Deborah K. Hansen. (2015) Effects of Maternal and Lactational Exposure to 2-Hydroxy-4-Methoxybenzone on Development and Reproductive Organs in Male and Female Rat Offspring. Birth Defects Research Part B: Developmental and Reproductive Toxicology 104:1, pages 35-51.
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Germaine M. Buck Louis, Kurunthachalam Kannan, Katherine J. Sapra, José Maisog & Rajeshwari Sundaram. (2014) Urinary Concentrations of Benzophenone-Type Ultraviolet Radiation Filters and Couples' Fecundity. American Journal of Epidemiology 180:12, pages 1168-1175.
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Sujin Kim & Kyungho Choi. (2014) Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: A mini-review. Environment International 70, pages 143-157.
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Zacarías León GonzálezZacarías León González. 2014. Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products. Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products 3 23 .
Alberto Chisvert, Zacarías León-González, Isuha Tarazona, Amparo Salvador & Dimosthenis Giokas. (2012) An overview of the analytical methods for the determination of organic ultraviolet filters in biological fluids and tissues. Analytica Chimica Acta 752, pages 11-29.
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Daryl J. Fediuk, Tao Wang, Yufei Chen, Fiona E. Parkinson, Michael P. Namaka, Keith J. Simons, Frank J. Burczynski & Xiaochen Gu. (2012) Metabolic Disposition of the Insect Repellent DEET and the Sunscreen Oxybenzone Following Intravenous and Skin Administration in Rats. International Journal of Toxicology 31:5, pages 467-476.
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Daryl J. Fediuk, Tao Wang, Yufei Chen, Fiona E. Parkinson, Michael P. Namaka, Keith J. Simons, Frank J. Burczynski & Xiaochen Gu. (2011) Tissue disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and topical administration in rats. Biopharmaceutics & Drug Disposition 32:7, pages 369-379.
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Daryl J. Fediuk, Tao Wang, Joshua E. Raizman, Fiona E. Parkinson & Xiaochen Gu. (2010) Tissue Deposition of the Insect Repellent DEET and the Sunscreen Oxybenzone From Repeated Topical Skin Applications in Rats. International Journal of Toxicology 29:6, pages 594-603.
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Zacarías León, Alberto Chisvert, Isuha Tarazona & Amparo Salvador. (2010) Solid-phase extraction liquid chromatography–tandem mass spectrometry analytical method for the determination of 2-hydroxy-4-methoxybenzophenone and its metabolites in both human urine and semen. Analytical and Bioanalytical Chemistry 398:2, pages 831-843.
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J. Frank Nash. 2008. Clinical Guide to Sunscreens and Photoprotection. Clinical Guide to Sunscreens and Photoprotection 139 154 .
Hee-Kyung Jeon, Sailendra Nath Sarma, Youn-Jung Kim & Jae-Chun Ryu. (2008) Toxicokinetics and metabolisms of benzophenone-type UV filters in rats. Toxicology 248:2-3, pages 89-95.
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JF. Nash. (2006) Human Safety and Efficacy of Ultraviolet Filters and Sunscreen Products. Dermatologic Clinics 24:1, pages 35-51.
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Donald J. AbrahamKhawla Abu‐Izza, Vincent Li & Graham Parr. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 411 472 .
Yoshio Nakagawa & Toshinari Suzuki. (2002) Metabolism of 2-hydroxy-4-methoxybenzophenone in isolated rat hepatocytes and xenoestrogenic effects of its metabolites on MCF-7 human breast cancer cells. Chemico-Biological Interactions 139:2, pages 115-128.
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J. Engelmann, G. Leyhausen, D. Leibfritz & W. Geurtsen. (2016) Metabolic Effects of Dental Resin Components in vitro Detected by NMR Spectroscopy. Journal of Dental Research 80:3, pages 869-875.
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Jiang, Roberts, Collins & Benson. (2001) Absorption of sunscreens across human skin: an evaluation of commercial products for children and adults. British Journal of Clinical Pharmacology 48:4, pages 635-637.
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Abdelrazak M. Kadry, Chukwuemeka S. Okereke, Mohamed S. Abdel‐Rahman, Marvin A. Friedman & Richard A. Davis. (2006) Pharmacokinetics of benzophenone‐3 after oral exposure in male rats. Journal of Applied Toxicology 15:2, pages 97-102.
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Steven H. Robison, Mauricio R. Odio, Edward D. Thompson, Marilyn J. Aardema & Albert L. Kraus. (2006) Assessment of the in vivo genotoxicity of 2‐hydroxy 4‐methoxybenzophenone. Environmental and Molecular Mutagenesis 23:4, pages 312-317.
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