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Journal of Toxicology and Environmental Health Volume 19, 1986 - Issue 4
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Original Articles

Mutagen activation of 1,2‐dibromo‐3‐chloropropane by cytosolic glutathione s‐transferases and microsomal enzymes

George E. Miller Toxicology Program, Department of Environmental and Industrial Health, The University of Michigan, Ann Arbor, Michigan
,
Michael J. Brabec Deparment of Chemistry, Eastern Michigan University, Ypsilanti, Michigan
&
Arun P. Kulkarni Toxicology Program, Department of Environmental and Industrial Health, The University of Michigan, M6216, SPH‐II, Ann Arbor, Michigan, 48109
Pages 503-518 | Received 11 Apr 1986, Accepted 09 Jun 1986, Published online: 20 Oct 2009

Citations (14)

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HEATHERA. CLARK & SUZANNEM. SNEDEKER. (2005) Critical Evaluation of the Cancer Risk of Dibromochloropropane (DBCP). Journal of Environmental Science and Health, Part C 23:2, pages 215-260.
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Articles from other publishers (13)

Julie A. Cox, Edwin P. Zwart, Mirjam Luijten & Paul A. White. (2018) The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization . Environmental and Molecular Mutagenesis 60:4, pages 331-347.
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 33 .
Arun Kulkarni. 2005. Developmental and Reproductive Toxicology. Developmental and Reproductive Toxicology 525 570 .
Hong-Gyum Kim, Keum-Nam Park, Young-Wook Cho, Eun-Hee Park, James A. Fuchs & Chang-Jin Lim. (2001) Characterization and regulation of glutathione S-transferase gene from Schizosaccharomyces pombe. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1520:2, pages 179-185.
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Erik J. Søderlund, David J. Meyer, Brian Ketterer, Sidney D. Nelson, Erik Dybing & Jørn A. Holme. (1995) Metabolism of 1,2-dibromo-3-chloropropane by glutathione S-transferases. Chemico-Biological Interactions 97:3, pages 257-272.
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Samir A. Kouzi, Erik J. Søderlund, Erik Dybing, John H. N. Meerman & Sidney D. Nelson. (2004) Comparative toxicity of (+)‐(R)‐ and (−)‐(S)‐1,2‐dibromo‐3‐chloropropane. Chirality 7:5, pages 359-364.
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Marit Låg, James G. Omichinski, Erik Dybing, Sidney D. Nelson & Erik J. Søderlund. (1994) Mutagenic activity of halogenated propanes and propenes: effect of bromine and chlorine positioning. Chemico-Biological Interactions 93:1, pages 73-84.
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Michael Koob & Wolfgang Dekant. (1991) Bioactivation of xenobiotics by formation of toxic glutathione conjugates. Chemico-Biological Interactions 77:2, pages 107-136.
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Spyridon Vamvakas & M. W. Anders. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 13 24 .
Erik J. Søderlund, Marit Låg, Jørn A. Holme, Gunnar Brunborg, James G. Omichinski, Jon E. Dahl, Sidney D. Nelson & Erik Dybing. (2009) Species Differences in Kidney Necrosis and DNA Damage, Distribution and Glutathione‐Dependent Metabolism of 1,2‐Dibromo‐3‐chloropropane (DBCP). Pharmacology & Toxicology 66:4, pages 287-293.
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Marit Låg, James G. Omichinski, Erik J. Søderlund, Gunnar Brunborg, Jørn A. Holme, Jon E. Dahl, Sidney D. Nelson & Erik Dybing. (1989) Role of P-450 activity and glutathione levels in 1,2-dibromo-3-chloropropane tissue distribution, renal necrosis and in vivo DNA damage. Toxicology 56:3, pages 273-288.
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Marit Låg, Erik J. Søderlund, James G. Omichinski, Sidney D. Nelson & Erik Dybing. (1989) Metabolism of selectively methylated and deuterated analogs of 1,2-dibromo-3-chloropropane: Role in organ toxicity and mutagenicity. Chemico-Biological Interactions 69:1, pages 33-44.
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David R. Dohn, Michael J. Graziano & John E. Casida. (1988) Metabolites of [3-13C]1,2-dibromo-3-chloropropane in male rats studied by 13C and 1H-13C correlated two-dimensional NMR spectroscopy. Biochemical Pharmacology 37:18, pages 3485-3495.
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