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Original Articles

Immunomodulatory activities of extracellular metallothionein. II. effects on macrophage functions

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Pages 397-413 | Received 31 Aug 1994, Accepted 04 Nov 1994, Published online: 15 Oct 2009

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Sona Krizkova, Marketa Ryvolova, Jan Hrabeta, Vojtech Adam, Marie Stiborova, Tomas Eckschlager & Rene Kizek. (2012) Metallothioneins and zinc in cancer diagnosis and therapy. Drug Metabolism Reviews 44:4, pages 287-301.
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G. Dan, S. B. Lall & D. N. Rao. (2000) HUMORAL AND CELL MEDIATED IMMUNE RESPONSE TO CADMIUM IN MICE. Drug and Chemical Toxicology 23:2, pages 349-360.
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Articles from other publishers (41)

Alexandra Muntiu, Andrea Papait, Federica Vincenzoni, Alberto Vitali, Wanda Lattanzi, Pietro Romele, Anna Cargnoni, Antonietta Silini, Ornella Parolini & Claudia Desiderio. (2023) Disclosing the molecular profile of the human amniotic mesenchymal stromal cell secretome by filter-aided sample preparation proteomic characterization. Stem Cell Research & Therapy 14:1.
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Amy V. Thees, Kathryn M. Pietrosimone, Clare K. Melchiorre, Jeremiah N. Marden, Joerg Graf, Michael A. Lynes & Michele Maltz-Matyschsyk. (2021) PmtA Regulates Pyocyanin Expression and Biofilm Formation in Pseudomonas aeruginosa. Frontiers in Microbiology 12.
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Andrew J. Monteith & Eric P. Skaar. (2021) The impact of metal availability on immune function during infection. Trends in Endocrinology & Metabolism 32:11, pages 916-928.
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Jinxia Sun, Li Li, Lingyun Li, Liping Ding, Xiaokai Liu, Xianxiong Chen, Jinshun Zhang, Xin Qi, Jing Du & Zhong Huang. (2018) Metallothionein-1 suppresses rheumatoid arthritis pathogenesis by shifting the Th17/Treg balance. European Journal of Immunology 48:9, pages 1550-1562.
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Mohammad Tariqur Rahman & Muhammad Manjurul Karim. (2017) Metallothionein: a Potential Link in the Regulation of Zinc in Nutritional Immunity. Biological Trace Element Research 182:1, pages 1-13.
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Kavitha Subramanian Vignesh & George Deepe Jr.. (2017) Metallothioneins: Emerging Modulators in Immunity and Infection. International Journal of Molecular Sciences 18:10, pages 2197.
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Mohammad Tariqur Rahman, Nazmul Haque, Noor Hayaty Abu Kasim & Marc De Ley. 2017. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173 41 62 .
Lindsey Devisscher, Pieter Hindryckx, Michael A Lynes, Anouk Waeytens, Claude Cuvelier, Filip De Vos, Christian Vanhove, Martine De Vos & Debby Laukens. (2014) Role of metallothioneins as danger signals in the pathogenesis of colitis. The Journal of Pathology 233:1, pages 89-100.
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Rachel Spiering, Josée Wagenaar-Hilbers, Veerle Huijgen, Ruurd van der Zee, Peter J. S. van Kooten, Willem van Eden & Femke Broere. (2014) Membrane-Bound Metallothionein 1 of Murine Dendritic Cells Promotes the Expansion of Regulatory T Cells In Vitro. Toxicological Sciences 138:1, pages 69-75.
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H. Frouin, L.L. Loseto, G.A. Stern, M. Haulena & P.S. Ross. (2012) Mercury toxicity in beluga whale lymphocytes: Limited effects of selenium protection. Aquatic Toxicology 109, pages 185-193.
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Adrian K. West, Jacqueline Y. K. Leung & Roger S. Chung. (2011) Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins. JBIC Journal of Biological Inorganic Chemistry 16:7, pages 1115-1122.
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Michael W Pankhurst, William Bennett, Matthew TK Kirkcaldie, Adrian K West & Roger S Chung. (2011) Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice. Journal of Neuroinflammation 8:1, pages 172.
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Andrea D Raymond, Bethsebah Gekonge, Malavika S Giri, Aidan Hancock, Emmanouil Papasavvas, Jihed Chehimi, Andrew V Kossevkov, Calen Nicols, Malik Yousef, Karam Mounzer, Jane Shull, Jay Kostman, Louise Showe & Luis J Montaner. (2010) Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia. Journal of Leukocyte Biology 88:3, pages 589-596.
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Rudolfs Zalups & James KoropatnickMichael Lynes, Kathryn Pietrosimone, Gregory Marusov, Douglas Donaldson, Clare Melchiorre, Xiuyun Yin, David Lawrence & Michael McCabe. 2010. Cellular and Molecular Biology of Metals. Cellular and Molecular Biology of Metals 379 414 .
Heather M. McGee, Gregory M. Woods, Bill Bennett & Roger S. Chung. (2010) The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival. Photochemical & Photobiological Sciences 9:4, pages 586-596.
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Stephan ZbindenJinsong WangRemi AdenikaMarcel SchmidtJustin U. TilanAmir H. NajafiXinZhi PengRoberta M. Lassance-SoaresMicaela IantornoHakim MorsliLeonid GercenshteinGil Jin JangStephen E. EpsteinMary Susan Burnett. (2010) Metallothionein Enhances Angiogenesis and Arteriogenesis by Modulating Smooth Muscle Cell and Macrophage Function. Arteriosclerosis, Thrombosis, and Vascular Biology 30:3, pages 477-482.
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M.A. Lynes. 2010. Comprehensive Toxicology. Comprehensive Toxicology 549 566 .
Rebecca T. Emeny, Gregory Marusov, David A. Lawrence, Joan Pederson-Lane, Xiuyun Yin & Michael A. Lynes. (2009) Manipulations of metallothionein gene dose accelerate the response to Listeria monocytogenes. Chemico-Biological Interactions 181:2, pages 243-253.
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Brian Henderson & Samantha Henderson. (2008) Unfolding the relationship between secreted molecular chaperones and macrophage activation states. Cell Stress and Chaperones 14:4, pages 329-341.
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R. S. Chung, Y. K. Leung, C. W. Butler, Y. Chen, E. D. Eaton, M. W. Pankhurst, A. K. West & G. J. Guillemin. (2009) Metallothionein Treatment Attenuates Microglial Activation and Expression of Neurotoxic Quinolinic Acid Following Traumatic Brain Injury. Neurotoxicity Research 15:4, pages 381-389.
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Monica Nordberg, Walter Schaffner, Claudia A Blindauer, Ulrich Weser, Eva Freisinger, Silvia Atrian, Stephen R Sturzenbaum, Laura Vergani, Peter G C Campbell, Juan Hidalgo, Milan Vasak, David H Petering, Michael P Waalkes, Christopher Horst Lillig, Eric Achterberg, Gabriele Meloni, Bernhard Kraeutler, Rowena G Matthews, Rudolf K Thauer, Paul A Lindahl, Juan C Fontecilla Camps, John W Peters, Thomas Brunold, Mario Rivera, Kenneth D Karlin, Martha E Sosa-Torres & Russ HilleJuan Hidalgo, Roger Chung, Milena Penkowa & Milan Vašák. 2009. Metallothioneins and Related Chelators. Metallothioneins and Related Chelators 279 317 .
Hajo Haase & Lothar Rink. (2007) Signal transduction in monocytes: the role of zinc ions. BioMetals 20:3-4, pages 579-585.
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Milena Penkowa. (2006) Metallothioneins are multipurpose neuroprotectants during brain pathology. The FEBS Journal 273:9, pages 1857-1870.
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Xiuyun Yin, David A Knecht & Michael A Lynes. (2005) Metallothionein mediates leukocyte chemotaxis. BMC Immunology 6:1.
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R.S Chung & A.K West. (2004) A role for extracellular metallothioneins in CNS injury and repair. Neuroscience 123:3, pages 595-599.
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Lene B Køhler, Vladimir Berezin, Elisabeth Bock & Milena Penkowa. (2003) The role of metallothionein II in neuronal differentiation and survival. Brain Research 992:1, pages 128-136.
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Milena Penkowa, Jordi Camats, Mercedes Giralt, Amalia Molinero, Joaquín Hernández, Javier Carrasco, Iain L. Campbell & Juan Hidalgo. (2003) Metallothionein‐I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte‐targeted interleukin‐6 expression. Glia 42:3, pages 287-306.
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J YOUN, S-H HWANG, Z-Y RYOO, M A LYNES, D-J PAIK, H-S CHUNG & H-Y KIM. (2002) Metallothionein suppresses collagen-induced arthritis via induction of TGF- β and down-regulation of proinflammatory mediators . Clinical and Experimental Immunology 129:2, pages 232-239.
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Mercedes Giralt, Milena Penkowa, Joaquı́n Hernández, Amalia Molinero, Javier Carrasco, Natalia Lago, Jordi Camats, Iain L. Campbell & Juan Hidalgo. (2002) Metallothionein-1+2 Deficiency Increases Brain Pathology in Transgenic Mice with Astrocyte-Targeted Expression of Interleukin 6. Neurobiology of Disease 9:3, pages 319-338.
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Milena Penkowa, Mercedes Giralt, Jordi Camats & Juan Hidalgo. (2002) Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6‐aminonicotinamide. Journal of Comparative Neurology 444:2, pages 174-189.
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Mercedes Giralt, Milena Penkowa, Natalia Lago, Amalia Molinero & Juan Hidalgo. (2002) Metallothionein-1+2 Protect the CNS after a Focal Brain Injury. Experimental Neurology 173:1, pages 114-128.
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E. Canpolat & M. A. Lynes. (2001) In Vivo Manipulation of Endogenous Metallothionein with a Monoclonal Antibody Enhances a T-Dependent Humoral Immune Response. Toxicological Sciences 62:1, pages 61-70.
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S Pillet, V Lesage, M Hammill, D.G Cyr, J.-M Bouquegneau & M Fournier. (2000) In Vitro Exposure of Seal Peripheral Blood Leukocytes to Different Metals Reveal a Sex-Dependent Effect of Zinc on Phagocytic Activity. Marine Pollution Bulletin 40:11, pages 921-927.
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Kevin C. Crowthers, Victoria Kline, Charles Giardina & Michael A. Lynes. (2000) Augmented Humoral Immune Function in Metallothionein-Null Mice. Toxicology and Applied Pharmacology 166:3, pages 161-172.
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Tomoki Kimura, Ikuyo Oguro, Junya Kohroki, Miyako Takehara, Norio Itoh, Tsuyoshi Nakanishi & Keiichi Tanaka. (2000) Metallothionein-Null Mice Express Altered Genes during Development. Biochemical and Biophysical Research Communications 270:2, pages 458-461.
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T Sugiura & U Yamashita. (2000) B cell stimulating activity of metallothionein in vitro. International Journal of Immunopharmacology 22:2, pages 113-122.
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Robert S Anderson, Kavita M Patel & G Roesijadi. (1999) Oyster metallothionein as an oxyradical scavenger: implications for hemocyte defense responses. Developmental & Comparative Immunology 23:6, pages 443-449.
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M. A. Lynes, C. A. Richardson, R. McCabe, K. C. Crowthers, J. C. Lee, J. Youn, I. B. Schweitzer & L. D. Shultz. 1999. Metallothionein IV. Metallothionein IV 437 444 .
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