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Original Articles

USE OF PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS TO ESTABLISH BIOLOGICAL EXPOSURE INDEXES

Pages 369-374 | Published online: 04 Jun 2010

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Irène Sari-Minodier, Ginette Truchon, Ginette Charest-Tardif, Anick Bérubé & Robert Tardif. (2009) The Effect of Workload on Biological Monitoring of Occupational Exposure to Toluene and N-Hexane: Contribution of Physiologically Based Toxicokinetic Modeling. Journal of Occupational and Environmental Hygiene 6:7, pages 415-432.
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ChadM. Thompson, Babasaheb Sonawane, HughA. Barton, RobertS. DeWoskin, JohnC. Lipscomb, Paul Schlosser, WeihsuehA. Chiu & Kannan Krishnan. (2008) Approaches for Applications of Physiologically Based Pharmacokinetic Models in Risk Assessment. Journal of Toxicology and Environmental Health, Part B 11:7, pages 519-547.
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Karla D. Thrall, Jolen J. Soelberg, Karl K. Weitz & Angela D. Woodstock. (2002) DEVELOPMENT OF A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR METHYL ETHYL KETONE IN F344 RATS. Journal of Toxicology and Environmental Health, Part A 65:13, pages 881-896.
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David J. George & Annette M. Shipp. (2002) Exposure assessment. Journal of Toxicology: Cutaneous and Ocular Toxicology 21:1-2, pages 31-50.
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Articles from other publishers (23)

Kevin N. Woodward. 2018. Regulatory Toxicology in the European Union. Regulatory Toxicology in the European Union 163 242 .
Daan Huizer, Mark A.J. Huijbregts, Joost G.M. van Rooij & Ad M.J. Ragas. (2014) Testing the coherence between occupational exposure limits for inhalation and their biological limit values with a generalized PBPK-model: The case of 2-propanol and acetone. Regulatory Toxicology and Pharmacology 69:3, pages 408-415.
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Kevin Woodward & Kevin WoodwardK. N Woodward. 2012. Toxicological Effects of Veterinary Medicinal Products in Humans. Toxicological Effects of Veterinary Medicinal Products in Humans 81 116 .
Chu-Chih Chen, Meng-Chiuan Shih & Kuen-Yuh Wu. (2011) Exposure reconstruction using a physiologically based toxicokinetic model with cumulative amount of metabolite in urine: a case study of trichloroethylene inhalation. Stochastic Environmental Research and Risk Assessment 26:1, pages 21-31.
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Jelle Vlaanderen, Lützen Portengen, Stephen M. Rappaport, Deborah C. Glass, Hans Kromhout & Roel Vermeulen. (2011) The Impact of Saturable Metabolism on Exposure-Response Relations in 2 Studies of Benzene-induced Leukemia. American Journal of Epidemiology 174:5, pages 621-629.
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Chu-Chih Chen, Meng-Chiuan Shih & Kuen-Yuh Wu. (2009) Exposure estimation using repeated blood concentration measurements. Stochastic Environmental Research and Risk Assessment 24:3, pages 445-454.
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Hon-Wing Leung. 2009. General and Applied Toxicology. General and Applied Toxicology.
Chu-Chih Chen, Meng-Chiuan Shih, Kuen-Yuh Wu & Pranab K. Sen. (2007) Exterior exposure estimation using a one-compartment toxicokinetic model with blood sample measurements. Journal of Mathematical Biology 56:5, pages 611-633.
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Yasong Lu, Susan Rieth, Manupat Lohitnavy, James Dennison, Hisham El-Masri, Hugh A. Barton, James Bruckner & Raymond S.H. Yang. (2008) Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane. Regulatory Toxicology and Pharmacology 50:2, pages 249-260.
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K.N. Woodward. (2008) Assessment of user safety, exposure and risk to veterinary medicinal products in the European Union. Regulatory Toxicology and Pharmacology 50:1, pages 114-128.
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S.M. Hays, R.A. Becker, H.W. Leung, L.L. Aylward & D.W. Pyatt. (2007) Biomonitoring equivalents: A screening approach for interpreting biomonitoring results from a public health risk perspective. Regulatory Toxicology and Pharmacology 47:1, pages 96-109.
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Robert De Woskin, Chadwick Thompson, Weihsueh Chiu, Paul Schlosser, Carolyn Smallwood, Jeff Swartout, Linda Teuschler & Allan Marcus. 2006. Toxicokinetics and Risk Assessment. Toxicokinetics and Risk Assessment 301 348 .
James E DennisonPhilip L Bigelow & Melvin E Andersen. (2016) Occupational exposure limits in the context of solvent mixtures, consumption of ethanol, and target tissue dose. Toxicology and Industrial Health 20:6-10, pages 165-175.
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Ivan Nestorov. (2003) Whole Body Pharmacokinetic Models. Clinical Pharmacokinetics 42:10, pages 883-908.
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Fredrik Jonsson & Gunnar Johanson. (2002) Physiologically Based Modeling of the Inhalation Kinetics of Styrene in Humans Using a Bayesian Population Approach. Toxicology and Applied Pharmacology 179:1, pages 35-49.
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George Christakos & Vikram M. Vyas. (1998) A novel method for studying population health impacts of spatiotemporal ozone distribution. Social Science & Medicine 47:8, pages 1051-1066.
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Crispin H. Pierce, Russell L. Dills, Thomas A. Lewandowski, Michael S. Morgan, Mike A. Wessels, Danny D. Shen & David A. Kalman. (2006) Estimation of Background Exposure to Toluene Using a Physiologically‐Based Kinetic Model. Journal of Occupational Health 39:2, pages 130-137.
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Harvey J. ClewellIIIIII & Melvin E. Andersen. (1996) Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk. Toxicology 111:1-3, pages 315-329.
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S. Lapar�, R. Tardif & J. Brodeur. (1995) Effect of various exposure scenarios on the biological monitoring of organic solvents in alveolar air. International Archives of Occupational and Environmental Health 67:6, pages 375-394.
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Hon-Wing Leung & Dennis J. Paustenbach. (1995) Physiologically based pharmacokinetic and pharmacodynamic modeling in health risk assessment and characterization of hazardous substances. Toxicology Letters 79:1-3, pages 55-65.
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Steven B. Charnick, Ryosei Kawai, Jerry R. Nedelman, Michel Lemaire, Werner Niederberger & Hitoshi Sato. (1995) Physiologically based pharmacokinetic modeling as a tool for drug development. Journal of Pharmacokinetics and Biopharmaceutics 23:2, pages 217-229.
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S. Lapar�, R. Tardif & J. Brodeur. (1993) Effect of various exposure scenarios on the biological monitoring of organic solvents in alveolar air. International Archives of Occupational and Environmental Health 64:8, pages 569-580.
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