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Toxicology Mechanisms and Methods Volume 17, 2007 - Issue 2
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Research Article

Adaptation of an In Vitro Phospholipidosis Assay to an Automated Image Analysis System

Mark E. Schurdak Biomolecular Screening, GPRD, Abbott Laboratories, 100 Abbott Park Road, Abbott ParkIL, 60064, USA
,
Lawrence A. Vernetti Biomolecular Screening, GPRD, Abbott Laboratories, 100 Abbott Park Road, Abbott ParkIL, 60064, USA
,
Stephen J. Abel Cellular and Molecular Toxicology, GPRD, Abbott Laboratories, 100 Abbott Park Road, Abbott ParkIL, 60064, USA
&
Christine Thiffault Cellular and Molecular Toxicology, GPRD, Abbott Laboratories, 100 Abbott Park Road, Abbott ParkIL, 60064, USA
Pages 77-86 | Received 13 Apr 2006, Accepted 25 May 2006, Published online: 09 Oct 2008

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Maria Teresa Donato, Maria José Gómez-Lechón & Laia Tolosa. (2017) Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies. Expert Opinion on Drug Discovery 12:2, pages 201-211.
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Articles from other publishers (7)

Liliana Pedro & Patrick J. Rudewicz. (2020) Analysis of Live Single Cells by Confocal Microscopy and High-Resolution Mass Spectrometry to Study Drug Uptake, Metabolism, and Drug-Induced Phospholipidosis. Analytical Chemistry 92:24, pages 16005-16015.
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Richard J. Weaver, Eric A. Blomme, Amy E. Chadwick, Ian M. Copple, Helga H. J. Gerets, Christopher E. Goldring, Andre Guillouzo, Philip G. Hewitt, Magnus Ingelman-Sundberg, Klaus Gjervig Jensen, Satu Juhila, Ursula Klingmüller, Gilles Labbe, Michael J. Liguori, Cerys A. Lovatt, Paul Morgan, Dean J. Naisbitt, Raymond H. H. Pieters, Jan Snoeys, Bob van de Water, Dominic P. Williams & B. Kevin Park. (2019) Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. Nature Reviews Drug Discovery 19:2, pages 131-148.
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Davide Germano, Marianne Uteng, Francois Pognan, Salah-Dine Chibout & Armin Wolf. (2015) Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment. Toxicology in Vitro 30:1, pages 79-94.
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Laia Tolosa, M. José Gómez-Lechón & M. Teresa Donato. (2015) High-content screening technology for studying drug-induced hepatotoxicity in cell models. Archives of Toxicology 89:7, pages 1007-1022.
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Dimitri Semizarov & Eric Blomme. 2008. Genomics in Drug Discovery and Development. Genomics in Drug Discovery and Development 293 327 .
Chen Zhao, Minghua Sun, Youssef L. Bennani, Sujatha M. Gopalakrishnan, David G. Witte, Thomas R. Miller, Kathleen M. Krueger, Kaitlin E. Browman, Christine Thiffault, Jill Wetter, Kennan C. Marsh, Arthur A. Hancock, Timothy A. Esbenshade & Marlon D. Cowart. (2008) The Alkaloid Conessine and Analogues as Potent Histamine H 3 Receptor Antagonists . Journal of Medicinal Chemistry 51:17, pages 5423-5430.
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Robert J. Altenbach, Huaqing Liu, Patricia N. Banfor, Kaitlin E. Browman, Gerard B. Fox, Ryan M. Fryer, Victoria A. Komater, Kathleen M. Krueger, Kennan Marsh, Thomas R. Miller, Jia Bao Pan, Liping Pan, Minghua Sun, Christine Thiffault, Jill Wetter, Chen Zhao, Deliang Zhou, Timothy A. Esbenshade, Arthur A. Hancock & Marlon D. Cowart. (2007) Synthesis, Potency, and In Vivo Profiles of Quinoline Containing Histamine H 3 Receptor Inverse Agonists . Journal of Medicinal Chemistry 50:22, pages 5439-5448.
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