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Toxicology Mechanisms and Methods Volume 17, 2007 - Issue 6
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Research Article

Effect of Ellagic Acid, a Plant Polyphenol, on Fibrotic Markers (MMPs and TIMPs) during Alcohol-Induced Hepatotoxicity

N. Devipriya Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India
,
A. Ram Sudheer Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India
,
M. Srinivasan Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India
&
Venugopal P. Menon Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India
Pages 349-356 | Received 17 Sep 2006, Accepted 05 Nov 2006, Published online: 09 Oct 2008

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Jozaa Z. ALTamimi, Ghedeir M. Alshammari, Nora A. AlFaris, Reham I. Alagal, Dalal H. Aljabryn, Norah A. Albekairi, Mahmoud Ahmad Alkhateeb & Mohammed Abdo Yahya. (2022) Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK. Pharmaceutical Biology 60:1, pages 25-37.
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Gamal Allam, Abdelaziz S.A. Abuelsaad, Mohammed A. Alblihed & Adnan A. Alsulaimani. (2016) Ellagic acid reduces murine schistosomiasis mansoni immunopathology via up-regulation of IL-10 and down-modulation of pro-inflammatory cytokines production. Immunopharmacology and Immunotoxicology 38:4, pages 286-297.
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Chinnadurai Saravanan & Sushil Kumar Singh. (2011) Status of research on MMPs in India. Expert Opinion on Therapeutic Targets 15:6, pages 715-728.
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P. Latha, D. Chaitanya & R. Rukkumani. (2010) Protective effect of Phyllanthus niruri on alcohol and heated sunflower oil induced hyperlipidemia in Wistar rats. Toxicology Mechanisms and Methods 20:8, pages 498-503.
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Usman Sabir, Hong‐mei Gu & Da‐Wei Zhang. (2023) Extracellular matrix turnover: phytochemicals target and modulate the dual role of matrix metalloproteinases ( MMPs ) in liver fibrosis . Phytotherapy Research 37:11, pages 4932-4962.
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Tong Wang & Zi-hui Xu. (2023) Natural Compounds with Aldose Reductase (AR) Inhibition: A Class of Medicative Agents for Fatty Liver Disease. Combinatorial Chemistry & High Throughput Screening 26:11, pages 1929-1944.
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Wenjuan Xu, Longde Wang, Yuanyuan Niu, Lanfang Mao, Xiaojuan Du, Ping Zhang, Zhengju Li, Hongfang Li & Ning Li. (2022) A review of edible plant-derived natural compounds for the therapy of liver fibrosis. European Journal of Gastroenterology & Hepatology 35:2, pages 133-152.
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Lihua Li, Kunpeng Wang, Rongjun Jia, Jing xie, Liman Ma, Zhiqing Hao, Weiwei Zhang, Jinggang Mo & Fu Ren. (2022) Ferroportin-dependent ferroptosis induced by ellagic acid retards liver fibrosis by impairing the SNARE complexes formation. Redox Biology 56, pages 102435.
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Xianjun Liu, Xinxin Gao, Hao Li, Zhandong Li, Xiaoe Wang, Li Zhang, Bo Wang, Xinxin Chen, Xianglong Meng & Jiaao Yu. (2021) Ellagic acid exerts anti-fibrotic effects on hypertrophic scar fibroblasts via inhibition of TGF-β1/Smad2/3 pathway. Applied Biological Chemistry 64:1.
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Ajit Kumar, Preeti Kaushik, Sandra Incerpi, Jens Z. Pedersen, Sanjay Goel, Ashok K. Prasad, Vishwajeet Rohil, Virinder S. Parmar, Luciano Saso & Christophe Len. (2021) Evaluation of the Free Radical Scavenging Activities of Ellagic Acid and Ellagic Acid Peracetate by EPR Spectrometry. Molecules 26:16, pages 4800.
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Venkatasubramanian Aishwarya, Solairaja Solaipriya & Venkatabalasubramanian Sivaramakrishnan. (2020) Role of ellagic acid for the prevention and treatment of liver diseases. Phytotherapy Research 35:6, pages 2925-2944.
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Liang Zhao, Arshad Mehmood, Dongdong Yuan, Muhammad Usman, Mian Anjum Murtaza, Sanabil Yaqoob & Chengtao Wang. (2021) Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds. Nutrients 13:5, pages 1612.
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Ambreen Shoaib, Saad Saeed Alqahtani, Lubna Azmi, Tarique Anwer, Andleeb Khan, Saeed Al Shahrani, Ajaz Ahmad & Muneeb U. Rehman. 2020. Therapeutic Applications of Honey and its Phytochemicals. Therapeutic Applications of Honey and its Phytochemicals 85 112 .
Longxin Qiu, Chang Guo & Baoyu Hua. (2019) Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview. BioMed Research International 2019, pages 1-8.
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Manjeshwar Shrinath Baliga, Arnadi Ramachandrayya Shivashankara, Sunitha Venkatesh, Harshith P. Bhat, Princy Louis Palatty, Ganesh Bhandari & Suresh Rao. 2019. Dietary Interventions in Liver Disease. Dietary Interventions in Liver Disease 79 89 .
Nehal A. AfifiMarwa A. IbrahimMona K. Galal. (2018) Hepatoprotective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats. Canadian Journal of Physiology and Pharmacology 96:6, pages 624-629.
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Adilson Costa, Michael Yi Bonner & Jack L. Arbiser. (2016) Use of Polyphenolic Compounds in Dermatologic Oncology. American Journal of Clinical Dermatology 17:4, pages 369-385.
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Robert Domitrović & Iva Potočnjak. (2015) A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives. Archives of Toxicology 90:1, pages 39-79.
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Wylly Ramsés García-Niño & Cecilia Zazueta. (2015) Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection. Pharmacological Research 97, pages 84-103.
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Arnadi Ramachandrayya Shivashankara, Sunitha Venkatesh, Harshith P. Bhat, Princy Louis Palatty & Manjeshwar Shrinath Baliga. 2015. Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults. Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults 163 170 .
Nathalie Janel & Christophe Noll. 2014. Polyphenols in Human Health and Disease. Polyphenols in Human Health and Disease 665 679 .
Marta Marín, Rosa María Giner, José-Luis Ríos & María Carmen Recio. (2013) Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis. Journal of Ethnopharmacology 150:3, pages 925-934.
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Ming-cheng Lin & Mei-chin Yin. (2013) Preventive Effects of Ellagic Acid Against Doxorubicin-Induced Cardio-Toxicity in Mice. Cardiovascular Toxicology 13:3, pages 185-193.
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Saba, Somaira Khan, Suhel Parvez, Bhushan Chaudhari, Firoz Ahmad, Sameya Anjum & Sheikh Raisuddin. (2013) Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity in Wistar rats. Food and Chemical Toxicology 58, pages 210-219.
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Pulok K. Mukherjee, Niladri Maity, Neelesh K. Nema & Birendra K. Sarkar. 2013. 91 113 .
A.R. Shivashankara, V. Sunitha, H.P. Bhat, P.L. Palatty & M.S. Baliga. 2013. Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease. Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease 743 758 .
Shi-Biao Wu, Keyvan Dastmalchi, Chunlin Long & Edward J. Kennelly. (2012) Metabolite Profiling of Jaboticaba (Myrciaria cauliflora) and Other Dark-Colored Fruit Juices. Journal of Agricultural and Food Chemistry 60:30, pages 7513-7525.
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Keyvan Dastmalchi, Gema Flores, Shi-Biao Wu, Chunhui Ma, Abdoulaye J. Dabo, Kathleen Whalen, Kurt A. Reynertson, Robert F. Foronjy, Jeanine M. D´Armiento & Edward J. Kennelly. (2012) Edible Myrciaria vexator fruits: Bioactive phenolics for potential COPD therapy. Bioorganic & Medicinal Chemistry 20:14, pages 4549-4555.
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Chandrashekaran Girish & Suresh Chandra Pradhan. (2011) Indian herbal medicines in the treatment of liver diseases: problems and promises. Fundamental & Clinical Pharmacology 26:2, pages 180-189.
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Arnadi Ramachandrayya Shivashankara, Aysha Azmidah, Raghavendra Haniadka, Manoj Ponadka Rai, Rajesh Arora & Manjeshwar Shrinath Baliga. (2012) Dietary agents in the prevention of alcohol-induced hepatotoxicty: preclinical observations. Food Funct. 3:2, pages 101-109.
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Mei-Ying Kuo, Hsiu-Chung Ou, Wen-Jane Lee, Wei-Wen Kuo, Ling-Ling Hwang, Tuzz-Ying Song, Chih-Yang Huang, Tsan-Hung Chiu, Kun-Ling Tsai, Chiou-Sheng Tsai & Wayne Huey-Herng Sheu. (2011) Ellagic Acid Inhibits Oxidized Low-Density Lipoprotein (OxLDL)-Induced Metalloproteinase (MMP) Expression by Modulating the Protein Kinase C-α/Extracellular Signal-Regulated Kinase/Peroxisome Proliferator-Activated Receptor γ/Nuclear Factor-κB (PKC-α/ERK/PPAR-γ/NF-κB) Signaling Pathway in Endothelial Cells. Journal of Agricultural and Food Chemistry 59:9, pages 5100-5108.
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