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Toxicology Mechanisms and Methods Volume 17, 2007 - Issue 7
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Research Article

New K-Oximes (K-27 and K-48) in Comparison with Obidoxime (LuH-6), HI-6, Trimedoxime (TMB-4), and Pralidoxime (2-PAM): Survival in Rats Exposed IP to the Organophosphate Paraoxon

G. A. Petroianu United Arab Emirates University, Al Ain-United Arab Emirates
,
M. Y. Hasan United Arab Emirates University, Al Ain-United Arab Emirates
,
S. M. Nurulain United Arab Emirates University, Al Ain-United Arab Emirates
,
N. Nagelkerke United Arab Emirates University, Al Ain-United Arab Emirates
,
J. Kassa University of Defense, Faculty of Military Health Sciences, Hradec Kralove
&
K. Kuča University of Defense, Faculty of Military Health Sciences, Hradec Kralove
Pages 401-408 | Received 01 Jul 2006, Accepted 01 Nov 2006, Published online: 09 Oct 2008

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Zuzana Kohoutova, David Malinak, Rudolf Andrys, Jana Svobodova, Miroslav Psotka, Monika Schmidt, Lukas Prchal & Kamil Musilek. (2022) Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 760-767.
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Kamil Kuca, Kamil Musilek, Daniel Jun, Miroslav Pohanka, Kallol Kumar Ghosh & Martina Hrabinova. (2010) Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 25:4, pages 509-512.
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D.E. Lorke, M.Y. Hasan, S.M. Nurulain, K. Kuča, A. Schmitt & G.A. Petroianu. (2009) Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6. Toxicology Mechanisms and Methods 19:4, pages 327-333.
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M.L. Zinovieva, N.V. Kurdil, M.G. Prodanchuk, O.P. Kravchuk & P.G. Zhminko. (2021) Modern aspects of development of basic therapy and prevention means of organophosphorus compounds acute poisoning (review of literature). Ukrainian Journal of Modern Toxicological Aspects 91:2, pages 79-90.
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Adriana Prado, Georg A. Petroianu, Dietrich E. Lorke & Jeremy W. Chambers. (2015) A trivalent approach for determining in vitro toxicology: Examination of oxime K027 . Journal of Applied Toxicology 35:2, pages 219-227.
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Jana Zdarova Karasova, Filip Zemek, Kamil Musilek & Kamil Kuca. (2012) Time-Dependent Changes of Oxime K027 Concentrations in Different Parts of Rat Central Nervous System. Neurotoxicity Research 23:1, pages 63-68.
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O. SOUKUP, J. KRŮŠEK, M. KANIAKOVÁ, U. K. KUMAR, M. OZ, D. JUN, J. FUSEK, K. KUČA & G. TOBIN. (2011) Oxime Reactivators and Their in Vivo and in Vitro Effects on Nicotinic Receptors. Physiological Research, pages 679-686.
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Kamil Kuca, Kamil Musilek, Miroslav Pohanka, Vlastimil Dohnal & Jiri Patocka. (2009) REACTIVATION POTENCY OF THE ACETYLCHOLINESTERASE REACTIVATOR OBIDOXIME IS LIMITED. Biomedical Papers 153:4, pages 259-262.
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D. E. Lorke & G. A. Petroianu. (2009) Minireview: does in‐vitro testing of oximes help predict their in‐vivo action after paraoxon exposure? . Journal of Applied Toxicology 29:6, pages 459-469.
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Kamil Kuča, Kamil Musílek, Daniel Jun, Miroslav Pohanka, Jana Žďárová Karasová, Ladislav Novotný & Lucie Musilová. (2009) Could oxime HI-6 really be considered as "broad-spectrum" antidote?. Journal of Applied Biomedicine 7:3, pages 143-149.
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S. M. Nurulain, D. E. Lorke, M. Y. Hasan, M. Shafiullah, K. Kuča, K. Musilek & G. A. Petroianu. (2009) Efficacy of Eight Experimental Bispyridinium Oximes Against Paraoxon-Induced Mortality: Comparison with the Conventional Oximes Pralidoxime and Obidoxime. Neurotoxicity Research 16:1, pages 60-67.
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D. E. Lorke, S. M. Nurulain, M. Y. Hasan, K. Kuča, K. Musilek & G. A. Petroianu. (2008) Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity . Journal of Applied Toxicology 28:7, pages 920-928.
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