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Toxicology Mechanisms and Methods Volume 18, 2008 - Issue 2-3: Special Issue on Computational Toxicology
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Research Article

Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action–Based Predictions of Chemical Carcinogenesis in Rodents

Edwin J. Matthews Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993-0002, USA
,
Naomi L. Kruhlak Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993-0002, USA
,
R. Daniel Benz Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993-0002, USA
,
Joseph F. Contrera Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993-0002, USA
,
Carol A. Marchant Lhasa Limited, 22-23 Blenheim Terrace, Woodhouse Lane, Leeds, LS2 9HD, United Kingdom
&
Chihae Yang Leadscope Inc., 1393 Dublin Road, Columbus, OH, 43215, USA
Pages 189-206 | Received 23 Oct 2007, Accepted 16 Nov 2007, Published online: 09 Oct 2008

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