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Toxicology Mechanisms and Methods Volume 19, 2009 - Issue 4
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Research Article

Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6

D.E. Lorke
,
M.Y. HasanDepartment of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
,
S.M. NurulainDepartment of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
,
K. KučaFaculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic
,
A. SchmittDepartment of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany
&
G.A. PetroianuDepartment of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAECorrespondence[email protected]
Pages 327-333 | Received 01 Mar 2008, Accepted 01 Jul 2008, Published online: 01 May 2009

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Kamil Kuca, Kamil Musilek, Daniel Jun, Miroslav Pohanka, Kallol Kumar Ghosh & Martina Hrabinova. (2010) Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 25:4, pages 509-512.
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Jiri Kassa, Jana Zdarova Karasova, Filip Caisberger & Jiri Bajgar. (2009) The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of soman poisoning in rats and mice. Toxicology Mechanisms and Methods 19:9, pages 547-551.
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Articles from other publishers (11)

Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang & Thimmasettappa Thippeswamy. (2022) Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Status Epilepticus Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology. Frontiers in Cellular Neuroscience 15.
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Huba Kalász, Kornélia Tekes, György Bátor, Jennifer Adeghate, Ernest Adeghate, Ferenc Darvas, József Fűrész & Gellért Karvaly. (2021) Investigation of the Experimental Pharmacokinetics of the Bis-Chlorinated Bis-pyridinium Mono-aldoxime Cholinesterase Reactivator K-868 in Rats. The Open Medicinal Chemistry Journal 15:1, pages 17-27.
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José Daniel Figueroa-Villar, Elaine C. Petronilho, Kamil Kuca & Tanos C.C. Franca. (2021) Review about Structure and Evaluation of Reactivators of Acetylcholinesterase Inhibited with Neurotoxic Organophosphorus Compounds. Current Medicinal Chemistry 28:7, pages 1422-1442.
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H. Kalász, S. M. Nurulain, G. Veress, S. Antus, F. Darvas, E. Adeghate, A. Adem, F. Hashemi & K. Tekes. (2015) Mini review on blood-brain barrier penetration of pyridinium aldoximes. Journal of Applied Toxicology 35:2, pages 116-123.
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Adriana Prado, Georg A. Petroianu, Dietrich E. Lorke & Jeremy W. Chambers. (2015) A trivalent approach for determining in vitro toxicology: Examination of oxime K027 . Journal of Applied Toxicology 35:2, pages 219-227.
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Jiří Kassa, Jana Zdarová Karasová, Růžena Pavlíková, Filip Caisberger & Jiří Bajgar. (2012) The Ability of Oxime Mixtures to Increase the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Cyclosarin Poisoning in Rats and Mice. Acta Medica (Hradec Kralove, Czech Republic) 55:1, pages 27-31.
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Jiri Kassa, Jana Zdarova Karasova, Vendula Sepsova, Filip Caisberger & Jiri Bajgar. (2011) A Comparison of the Reactivating and Therapeutic Efficacy of Chosen Combinations of Oximes With Individual Oximes Against VX in Rats and Mice. International Journal of Toxicology 30:5, pages 562-567.
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Jiri Kassa, Jana Zdarova Karasova, Vendula Sepsova & Filip Caisberger. (2011) The Benefit of Combinations of Oximes for the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Sarin Poisoning in Rats and Mice. Basic & Clinical Pharmacology & Toxicology 109:1, pages 30-34.
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Kamil Kuča, Kamil Musílek, Daniel Jun, Miroslav Pohanka, Jana Žďárová Karasová, Ladislav Novotný & Lucie Musilová. (2009) Could oxime HI-6 really be considered as "broad-spectrum" antidote?. Journal of Applied Biomedicine 7:3, pages 143-149.
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S. M. Nurulain, D. E. Lorke, M. Y. Hasan, M. Shafiullah, K. Kuča, K. Musilek & G. A. Petroianu. (2009) Efficacy of Eight Experimental Bispyridinium Oximes Against Paraoxon-Induced Mortality: Comparison with the Conventional Oximes Pralidoxime and Obidoxime. Neurotoxicity Research 16:1, pages 60-67.
Crossref
D. E. Lorke, S. M. Nurulain, M. Y. Hasan, K. Kuča, K. Musilek & G. A. Petroianu. (2008) Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity . Journal of Applied Toxicology 28:7, pages 920-928.
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