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Research Article

Acute and subchronic toxicity of danshensu in mice and rats

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Pages 363-368 | Received 06 Jan 2009, Accepted 10 Feb 2009, Published online: 07 May 2009

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Rutong Ren, Tian Wang, Na Jiang, Tongshen Liu, Yuan Du, Chong Li, Leiming Zhang & Fenghua Fu. (2010) Protective effects of Danshensu on liver injury induced by omethoate in rats. Toxicology Mechanisms and Methods 20:8, pages 510-514.
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Guisheng Li, Yonglin Gao, Shenjun Li, Chunmei Li, Xiaoyin Zhu, Min Li & Zhifeng Liu. (2009) Study on toxicity of danshensu in beagle dogs after 3-month continuous intravenous infusion. Toxicology Mechanisms and Methods 19:6-7, pages 441-446.
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Articles from other publishers (20)

Ruyu Wang, Xuwen Chen, Hongtao Li, Xixiang Chen, Donghui Sun, Danmei Yu, Jiani Lu, Yuanyuan Xie, Qian Zhang, Jianrong Xu, Weidong Zhang, Hongzhuan Chen, Shunying Liu & Lili Chen. (2023) Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti-inflammatory activity. International Journal of Biological Macromolecules, pages 128623.
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Yakun Yang, Jiaying Qi, Hua Wang, Yang Zhao, Yongchao Wu, Zhonglin Wu, Jing Shi, Weizhong Qu & Li Chu. (2022) Ameliorative effects of Danshensu from the functional food Salvia miltiorrhiza against arsenic trioxide-induced cardiac toxicity in vivo and in vitro: Involvement of inhibiting the AKT/IKK/NF-κB signaling pathway. Journal of Functional Foods 99, pages 105304.
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Qing Gao, Hao Deng, Zhengfei Yang, Qiuyue Yang, Yilin Zhang, Xiaopeng Yuan, Miao Zeng, Maojuan Guo, Wenyun Zeng, Xijuan Jiang & Bin Yu. (2022) Sodium danshensu attenuates cerebral ischemia–reperfusion injury by targeting AKT1. Frontiers in Pharmacology 13.
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Yuejin Xue, Liyuan Zhang, Lusha Zhang, Wei Sun, Zhirui Fang, Yuze Leng, Mengyao Li, Xiuyun Ren, Rui Zhang, Yingxue Zhang, Lu Chen & Hong Wang. (2022) Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1/ROS/mtDNA pathways without increasing bleeding risk. Phytomedicine 104, pages 154271.
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Yanan Chen, Rongrong Tian, Jin Xue, Jie Yu & Hui Wang. (2022) Sodium Danshensu mediates human T lymphocyte activation via NF‐κB and MAPK pathway regulation. MedComm – Future Medicine 1:2.
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Siyuan Zhang, Hua Luo, Shiyi Sun, Yating Zhang, Jiaqi Ma, Yuting Lin, Lin Yang, Dechao Tan, Chaomei Fu, Zhangfeng Zhong & Yitao Wang. (2022) Salvia miltiorrhiza Bge. (Danshen) for Inflammatory Bowel Disease: Clinical Evidence and Network Pharmacology-Based Strategy for Developing Supplementary Medical Application. Frontiers in Pharmacology 12.
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Qiongtao Song, Fuwen Zhang, Xue Han, Yanrong Yang, Ying Zhao & Junguo Duan. (2021) Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro. Experimental Eye Research 209, pages 108642.
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Dimitrina Zheleva-Dimitrova, Rumyana Simeonova, Reneta Gevrenova, Yonko Savov, Vessela Balabanova, Gazela Nasar-Eddin, Krum Bardarov & Nikolay Danchev. (2019) In vivo toxicity assessment of Clinopodium vulgare L. water extract characterized by UHPLC-HRMS. Food and Chemical Toxicology 134, pages 110841.
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Qiongtao Song, Yuanyuan Zhang, Xue han, Ying Zhang, Xuan Zhang, Yonggang Gao, Jianping Zhang, Li Chu & Senming Zhao. (2019) Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro. Biomedicine & Pharmacotherapy 109, pages 945-956.
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Mehdi Sharifi-Rad, Beraat Ozcelik, Gökçe Altın, Ceren Daşkaya-Dikmen, Miquel Martorell, Karina Ramírez-Alarcón, Pedro Alarcón-Zapata, Maria Flaviana B. Morais-Braga, Joara N.P. Carneiro, Antonio Linkoln Alves Borges Leal, Henrique Douglas Melo Coutinho, Rabin Gyawali, Reza Tahergorabi, Salam A. Ibrahim, Razieh Sahrifi-Rad, Farukh Sharopov, Bahare Salehi, María del Mar Contreras, Antonio Segura-Carretero, Surjit Sen, Krishnendu Acharya & Javad Sharifi-Rad. (2018) Salvia spp. plants-from farm to food applications and phytopharmacotherapy. Trends in Food Science & Technology 80, pages 242-263.
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Yanzhi Liu, Zhenshan Jia, Mohammed P. Akhter, Xiang Gao, Xiaobei Wang, Xiaoyan Wang, Gang Zhao, Xin Wei, You Zhou, Xiuli Wang, Curtis W. Hartman, Edward V. Fehringer, Liao Cui & Dong Wang. (2018) Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice. Nanomedicine: Nanotechnology, Biology and Medicine 14:7, pages 2271-2282.
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Qiongtao Song, Xi Chu, Xuan Zhang, Yifan Bao, Yuanyuan Zhang, Hui Guo, Yang Liu, Hongying Liu, Jianping Zhang, Ying Zhang & Li Chu. (2016) Mechanisms underlying the cardioprotective effect of Salvianic acid A against isoproterenol-induced myocardial ischemia injury in rats: Possible involvement of L-type calcium channels and myocardial contractility. Journal of Ethnopharmacology 189, pages 157-164.
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Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E. Olaleye, Jiajia Dong & Chuan Li. (2015) Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions. Drug Metabolism and Disposition 43:5, pages 669-678.
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Dan-dan Tian, Wei-wei Jia, Xin-wei Liu, Dan-dan Wang, Jun-hua Liu, Jia-jia Dong, Li Li, Fei-fei Du, Fang Xu, Feng-qing Wang, Yan Sun, Yu-xing Huang, Mei-juan Li, Li-hong Hu, Yan Zhu, Xiu-mei Gao, Chuan Li & Jun-ling Yang. (2015) Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen). Acta Pharmacologica Sinica 36:5, pages 627-643.
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Chao Guo, Ying Yin, Jialin Duan, Yanrong Zhu, Jiajia Yan, Guo Wei, Yue Guan, Xiaoxiao Wu, Yanhua Wang, Miaomaio Xi & Aidong Wen. (2015) Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats. Phytomedicine 22:2, pages 283-289.
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Guyoung Kwon, Hyun Ji Kim, Se Jin Park, Hyung Eun Lee, Hyun Woo, Young Je Ahn, Qingtao Gao, Jae Hoon Cheong, Dae Sik Jang & Jong Hoon Ryu. (2014) Anxiolytic-like effect of danshensu [(3-(3,4-dihydroxyphenyl)-lactic acid)] in mice. Life Sciences 101:1-2, pages 73-78.
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John H. K. Yeung. 2013. Evidence and Rational Based Research on Chinese Drugs. Evidence and Rational Based Research on Chinese Drugs 237 282 .
Meng Wang, Jin Liu, Bo Zhou, Rui Xu, Li Tao, Meilin Ji, Liping Zhu, Juan Jiang, Jiao Shen, Xiaolong Gui, Leilei Gu, Wenxia Bai, Wu Sun & Jianming Cheng. (2012) Acute and sub-chronic toxicity studies of Danshen injection in Sprague-Dawley rats. Journal of Ethnopharmacology 141:1, pages 96-103.
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Alice Chin, Yanqi Yang, Lei Chai, Ricky W. K. Wong & Abou-Bakr M. Rabie. (2011) Effects of medicinal herb salvia miltiorrhiza on osteoblastic cells in vitro. Journal of Orthopaedic Research 29:7, pages 1059-1063.
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G.-M. She, C. Xu, B. Liu & R.-B. Shi. (2010) Polyphenolic Acids from Mint (the Aerial of Mentha haplocalyx Briq.) with DPPH Radical Scavenging Activity. Journal of Food Science 75:4, pages C359-C362.
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