Advanced search
Publication Cover
Toxicology Mechanisms and Methods Volume 28, 2018 - Issue 4
Submit an article Journal homepage
655
Views
24
CrossRef citations to date
0
Altmetric
Research Article

Urban fine particulate matter (PM2.5) exposure destroys blood–testis barrier (BTB) integrity through excessive ROS-mediated autophagy

Yi WeiDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, China; ;Chongqing Key Laboratory of Child Urogenital Development and Tissue Engineering, Chongqing, China; ;Chongqing Key Laboratory of Pediatrics Chongqing, Chongqing, China; View further author information
,
Xi-Ning CaoChongqing Key Laboratory of Child Urogenital Development and Tissue Engineering, Chongqing, China; ;Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; View further author information
,
Xiang-Liang TangDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, China; ;Chongqing Key Laboratory of Child Urogenital Development and Tissue Engineering, Chongqing, China; View further author information
,
Lian-Ju ShenDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, China; ;Chongqing Key Laboratory of Child Urogenital Development and Tissue Engineering, Chongqing, China; ;Chongqing Key Laboratory of Pediatrics Chongqing, Chongqing, China; View further author information
,
Tao LinDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, China; ;Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; View further author information
,
Da-Wei HeDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, China; ;China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, ChinaView further author information
,
Sheng-De WuDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, China; ;Chongqing Key Laboratory of Child Urogenital Development and Tissue Engineering, Chongqing, China; Correspondence[email protected]
View further author information
&
Guang-Hui WeiDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, China; ;Chongqing Key Laboratory of Child Urogenital Development and Tissue Engineering, Chongqing, China; ;Chongqing Key Laboratory of Pediatrics Chongqing, Chongqing, China; ;Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; ;China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, ChinaCorrespondence[email protected]
View further author information
 show all
Pages 302-319 | Received 07 Sep 2017, Accepted 19 Nov 2017, Published online: 27 Dec 2017

Citations (24)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Jiao Ma, Zhuoxiao Han, Rui Jiao, Guanli Yuan, Cuiqing Ma, Xixin Yan & Aihong Meng. (2023) Irisin Ameliorates PM2.5-Induced Acute Lung Injury by Regulation of Autophagy Through AMPK/mTOR Pathway. Journal of Inflammation Research 16, pages 1045-1057.
Read now
Allie Sidwell, Samuel Cole Smith & Courtney Roper. (2022) A comparison of fine particulate matter (PM2.5) in vivo exposure studies incorporating chemical analysis. Journal of Toxicology and Environmental Health, Part B 25:8, pages 422-444.
Read now
Caixia Pei, Fei Wang, Demei Huang, Shihua Shi, Xiaomin Wang, Yilan Wang, Shuiqin Li, Yongcan Wu & Zhenxing Wang. (2021) Astragaloside IV Protects from PM2.5-Induced Lung Injury by Regulating Autophagy via Inhibition of PI3K/Akt/mTOR Signaling in vivo and in vitro. Journal of Inflammation Research 14, pages 4707-4721.
Read now

Articles from other publishers (21)

Ching-Yu Lin, Wen-Ling Chen, Ting-Zhen Chen, Sheng-Han Lee, Hao-Jan Liang, Charles C.-K. Chou, Chuan-Ho Tang & Tsun-Jen Cheng. (2021) Lipid changes in extrapulmonary organs and serum of rats after chronic exposure to ambient fine particulate matter. Science of The Total Environment 784, pages 147018.
Crossref
Soudeh Ghafouri-Fard, Hamed Shoorei, Mahdi Mohaqiq, Sayed Haidar Abbas Raza & Mohammad Taheri. (2021) The role of different compounds on the integrity of blood-testis barrier: A concise review based on in vitro and in vivo studies. Gene 780, pages 145531.
Crossref
Yung-Li Wang, Cai-Mei Zheng, Yu-Hsuan Lee, Ya-Yun Cheng, Yuh-Feng Lin & Hui-Wen Chiu. (2021) Micro- and Nanosized Substances Cause Different Autophagy-Related Responses. International Journal of Molecular Sciences 22:9, pages 4787.
Crossref
Lingjuan Wang, Dan Luo, Xiaolong Liu, Jianqiang Zhu, Fengli Wang, Bin Li & Liming Li. (2021) Effects of PM2.5 exposure on reproductive system and its mechanisms. Chemosphere 264, pages 128436.
Crossref
Yuanfeng Liu, Dongting Zhao, Wenyi Peng, Panpan Xue, Xiaojun Jiang, Shuting Chen, Huiqian Gao, Xinming Wang & Shaolong Feng. (2021) Atmospheric PM2.5 blocking up autophagic flux in HUVECs via inhibiting Sntaxin-17 and LAMP2. Ecotoxicology and Environmental Safety 208, pages 111450.
Crossref
Yu-An Chen, Yi-Kai Chang, Yann-Rong Su & Hong-Chiang Chang. (2020) Ambient sulfur dioxide could have an impact on testicular volume from a observational study on a population of infertile male. BMC Urology 20:1.
Crossref
Ying Li, Yu‐Le Yong, Menglin Yang, Weijia Wang, Xiaoyan Qu, Xiaomin Dang, Dong Shang, Yongping Shao, Jiankang Liu & Ying Chang. (2020) Fine particulate matter inhibits phagocytosis of macrophages by disturbing autophagy. The FASEB Journal 34:12, pages 16716-16735.
Crossref
Dong-Hui Pan, Jie Sheng, Xin-Yu Wang, Qian-Huan Huang, Jun-Jie Yan, Li-Zhen Wang, Run-Ling Yang, Dong-Jian Shi, Yu-Ping Xu & Ming-Qing Chen. (2020) In vivo SPECT imaging of an 131I-labeled PM 2.5 mimic substitute. Nuclear Science and Techniques 31:11.
Crossref
Wei Liu, Yalin Zhou, Yong Qin, Lanlan Yu, Ruijun Li, Yuhan Chen & Yajun Xu. (2020) Quercetin Intervention Alleviates Offspring’s Oxidative Stress, Inflammation, and Tight Junction Damage in the Colon Induced by Maternal Fine Particulate Matter (PM2.5) Exposure through the Reduction of Bacteroides. Nutrients 12:10, pages 3095.
Crossref
Wei Yang, Yanyi Xu, Hongjie Pan, Fang Tian, Yuzhu Wang, Minjie Xia, Jingying Hu, Mingjun Yang, Shimin Tao, Shenfei Sun, Haidong Kan, Runsheng Li, Zhekang Ying & Weihua Li. (2020) Chronic exposure to diesel exhaust particulate matter impairs meiotic progression during spermatogenesis in a mouse model. Ecotoxicology and Environmental Safety 202, pages 110881.
Crossref
Wei He, Hongzhen Peng, Jifei Ma, Qisheng Wang, Aiguo Li, Jichao Zhang, Huating Kong, Qingnuan Li, Yanhong Sun & Ying Zhu. (2020) Autophagy changes in lung tissues of mice at 30 days after carbon black‐metal ion co‐exposure. Cell Proliferation 53:7.
Crossref
Qixiao Jiang, Chao Zhang, Shen Chen, Limei Shi, Dao Chuan Li, Na Lv, Lianhua Cui, Yanxia Chen & Yuxin Zheng. (2020) Particulate Matter 2.5 Induced Developmental Cardiotoxicity in Chicken Embryo and Hatchling. Frontiers in Pharmacology 11.
Crossref
Krzysztof Pawlak & Zenon Nieckarz. (2020) The impact of smog on the concentration of particulate matter in the antelope house in the Silesian zoological garden. PeerJ 8, pages e9191.
Crossref
Yuanyuan Tian, Wei Song, Dongsheng Xu, Xiao Chen, Xiaojiao Li & Yuguang Zhao. (2020) Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2. Oxidative Medicine and Cellular Longevity 2020, pages 1-9.
Crossref
Chenxu Ge, Linfeng Hu, Deshuai Lou, Qiang Li, Jing Feng, Yekuan Wu, Jun Tan & Minxuan Xu. (2020) Nrf2 deficiency aggravates PM2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder. Aging 12:6, pages 4836-4865.
Crossref
Lihua Ren, Jing Huang, Jialiu Wei, Yu Zang, Yang Zhao, Shaowei Wu, Xiaohong Zhao, Xianqing Zhou, Zhiwei Sun & Hong Lu. (2020) Maternal exposure to fine particle matters cause autophagy via UPR-mediated PI3K-mTOR pathway in testicular tissue of adult male mice in offspring. Ecotoxicology and Environmental Safety 189, pages 109943.
Crossref
Ya-Ping Jiang, Jia-Mei Yang, Rui-Juan Ye, Ning Liu, Wen-Jin Zhang, Lin Ma, Ping Zheng, Jian-Guo Niu, Ping Liu & Jian-Qiang Yu. (2019) Protective effects of betaine on diabetic induced disruption of the male mice blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways. Biomedicine & Pharmacotherapy 120, pages 109474.
Crossref
Lei Wang, Jianying Xu, Hu Liu, Jie Li & Hailong Hao. (2019) PM2.5 inhibits SOD1 expression by up-regulating microRNA-206 and promotes ROS accumulation and disease progression in asthmatic mice. International Immunopharmacology 76, pages 105871.
Crossref
Na Du, Xiao‑Hua Li, Wan‑Guo Bao, Bin Wang, Guang Xu & Feng Wang. (2019) Resveratrol‑loaded nanoparticles inhibit enterovirus 71 replication through the oxidative stress‑mediated ERS/autophagy pathway. International Journal of Molecular Medicine.
Crossref
Lixiao Zhou, Xuan Su, Binghua Li, Chen Chu, Hongyue Sun, Ning Zhang, Bin Han, Chen Li, Bingjie Zou, Yujie Niu & Rong Zhang. (2019) PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse. Ecotoxicology and Environmental Safety 169, pages 551-563.
Crossref
Chunteng Jiang, Liping Jiang, Qiannan Li, Xiaofang Liu, Tianjiao Zhang, Linlin Dong, Tiehong Liu, Li Liu, Guoling Hu, Xiance Sun & Lijie Jiang. (2018) Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells. Toxicology 410, pages 26-40.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.