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Toxicology Mechanisms and Methods Volume 28, 2018 - Issue 5
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Review Article

Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective

Carlemi CalitzPharmacen™, Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa; View further author information
,
Josias H. HammanPharmacen™, Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa; View further author information
,
Stephen J. FeyDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, DenmarkView further author information
,
Krzysztof WrzesinskiDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, DenmarkCorrespondence[email protected]
View further author information
&
Chrisna GouwsPharmacen™, Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-5747-8214View further author information
ORCID Icon
Pages 369-385 | Received 23 Nov 2017, Accepted 25 Dec 2017, Published online: 18 Jan 2018

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Amrita Basu, Aneta Dydowiczová, James E. Trosko, Luděk Bláha & Pavel Babica. (2020) Ready to go 3D? A semi-automated protocol for microwell spheroid arrays to increase scalability and throughput of 3D cell culture testing. Toxicology Mechanisms and Methods 30:8, pages 590-604.
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Carlemi Calitz, Josias H. Hamman, Alvaro M. Viljoen, Stephen J. Fey, Krzysztof Wrzesinski & Chrisna Gouws. (2018) Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures. Toxicology Mechanisms and Methods 28:9, pages 641-652.
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Articles from other publishers (18)

Yinping Ma, Lei Hu, Jianhua Tang, Weiwei Guo, Yujie Feng, Yanmiao Liu & Fushan Tang. (2023) Three-Dimensional Cell Co-Culture Liver Models and Their Applications in Pharmaceutical Research. International Journal of Molecular Sciences 24:7, pages 6248.
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Iris Aparici Herraiz, Hugo R. Caires, Óscar Castillo-Fernández, Núria Sima, Lourdes Méndez-Mora, Ruth M. Risueño, Jetsumon Sattabongkot, Wanlapa Roobsoong, Aurora Hernández-Machado, Carmen Fernandez-Becerra, Cristina C. Barrias & Hernando A. del Portillo. (2022) Advancing Key Gaps in the Knowledge of Plasmodium vivax Cryptic Infections Using Humanized Mouse Models and Organs-on-Chips. Frontiers in Cellular and Infection Microbiology 12.
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Yurong Lai, Xiaoyan Chu, Li Di, Wei Gao, Yingying Guo, Xingrong Liu, Chuang Lu, Jialin Mao, Hong Shen, Huaping Tang, Cindy Q. Xia, Lei Zhang & Xinxin Ding. (2022) Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development. Acta Pharmaceutica Sinica B 12:6, pages 2751-2777.
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Yu-Hsu Chen, Yuan-Hao Ku, Kuo-Cheng Wang, Hung-Chi Chiang, Yu-Pao Hsu, Ming-Te Cheng, Ching-Shuen Wang & Yinshen Wee. (2022) Bioinspired Sandcastle Worm-Derived Peptide-Based Hybrid Hydrogel for Promoting the Formation of Liver Spheroids. Gels 8:3, pages 149.
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Khushboo Sharma, Prince Sharma, Shakti Kumar Dhiman, Pooja Chadha & Harvinder Singh Saini. (2022) Biochemical, genotoxic, histological and ultrastructural effects on liver and gills of fresh water fish Channa punctatus exposed to textile industry intermediate 2 ABS. Chemosphere 287, pages 132103.
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Krzysztof Wrzesinski, Søren Alnøe, Hans H. Jochumsen, Karoline Mikkelsen, Torsten D. Bryld, Julie S. Vistisen, Peter Willems Alnøe & Stephen J. Fey. 2021. Biomechanics and Functional Tissue Engineering. Biomechanics and Functional Tissue Engineering.
P. A. Opute & I. P. Oboh. (2021) Hepatotoxic Effects of Atrazine on Clarias gariepinus (Burchell, 1822): Biochemical and Histopathological Studies. Archives of Environmental Contamination and Toxicology 80:2, pages 414-425.
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Z. Sobańska, K. Domeradzka-Gajda, M. Szparaga, J. Grobelny, E. Tomaszewska, K. Ranoszek-Soliwoda, G. Celichowski, L. Zapór, K. Kowalczyk & M. Stępnik. (2020) Comparative analysis of biological effects of molybdenum(IV) sulfide in the form of nano- and microparticles on human hepatoma HepG2 cells grown in 2D and 3D models. Toxicology in Vitro 68, pages 104931.
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V. Gryshchenko. (2020) Influence of phospholipid-containing additives on the functional condition of organs and systems of mice. Ukrainian journal of veterinary sciences 11:3.
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Hongyan Guo, Jian Ji, Jia-sheng Wang & Xiulan Sun. (2020) Co-contamination and interaction of fungal toxins and other environmental toxins. Trends in Food Science & Technology 103, pages 162-178.
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V. A. Gryshchenko & V. S. Minina. (2020) Marker changes of blood plasma proteinogram in rats with toxic hepatitis. Regulatory Mechanisms in Biosystems 11:3, pages 360-366.
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Ritu Sharma & Rajinder Jindal. (2020) Assessment of cypermethrin induced hepatic toxicity in Catla catla: A multiple biomarker approach. Environmental Research 184, pages 109359.
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V. Gryshchenko, S. Sуsoliatin & S. Midyk. (2019) Fatty acids of lipids of blood serum and liver of rats with tetracyclin-induced hepatosis and at correction. Regulatory Mechanisms in Biosystems 10:4, pages 520-525.
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V. Gryshchenko. (2019) BLOOD AND ACID COMPOSITION OF BLOOD AND BILES IN CALVES AT ENTEROPATOLOGY AND APPLICATION OF MILK PHOSPHOLIPIDES. Ukrainian journal of veterinary sciences 10:4.
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Elisabeth Elje, Michelle Hesler, Elise Rundén-Pran, Pascal Mann, Espen Mariussen, Sylvia Wagner, Maria Dusinska & Yvonne Kohl. (2019) The comet assay applied to HepG2 liver spheroids. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 845, pages 403033.
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Fabio Gionfra, Paolo De Vito, Valentina Pallottini, Hung-Yun Lin, Paul J. Davis, Jens Z. Pedersen & Sandra Incerpi. (2019) The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer. Frontiers in Endocrinology 10.
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Clarissa Willers, Hanna Svitina, Michael J. Rossouw, Roan A. Swanepoel, Josias H. Hamman & Chrisna Gouws. (2019) Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux. Journal of Cancer Research and Clinical Oncology 145:8, pages 1949-1976.
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Viktoriya Gryshchenko, Olena Danchenko & Viktoriya Musiychuk. 2019. Modern Development Paths of Agricultural Production. Modern Development Paths of Agricultural Production 689 697 .

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