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Research Article

Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NFκB, oxidative stress, and apoptosis

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Pages 467-473 | Received 11 Feb 2018, Accepted 25 Mar 2018, Published online: 16 Apr 2018

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Abd El-Fattah B. M. El-Beltagy, Amira M.B. Saleh, Amany Attaallah  & Reham A. Gahnem. (2021) Therapeutic role of Azadirachta indica leaves ethanolic extract against diabetic nephropathy in rats neonatally induced by streptozotocin. Ultrastructural Pathology 45:6, pages 391-406.
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Esraa K. Abd-alhameed, Amany A. Azouz, Amira M. Abo-Youssef & Fares E.M. Ali. (2024) The enteroprotective effect of nifuroxazide against methotrexate-induced intestinal injury involves co-activation of PPAR-γ, SIRT1, Nrf2, and suppression of NF-κB and JAK1/STAT3 signals. International Immunopharmacology 127, pages 111298.
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R.M. Salama & M.A. Omar. (2023) Anti-aging effect of nifuroxazide on skin changes of aged male rat models via modulating immunoreactivity of IL-6/NF-κB/Caspase-3. Morphologie 107:359, pages 100605.
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Emad H. M. Hassanein, Mustafa Ahmed Abdel-Reheim, Hanan S. Althagafy, Mohamed S. Hemeda, Rania A. Gad & Asmaa Ramadan Abdel-Sattar. (2023) Nifuroxazide attenuates indomethacin-induced renal injury by upregulating Nrf2/HO-1 and cytoglobin and suppressing NADPH-oxidase, NF-κB, and JAK-1/STAT3 signals. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Yingjun Liu, Wenkuan Wang, Jintao Zhang, Shuo Gao, Tingting Xu & Yonghui Yin. (2023) JAK/STAT signaling in diabetic kidney disease. Frontiers in Cell and Developmental Biology 11.
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Hanan S. Althagafy, Mostafa K. Abd El-Aziz, Islam M. Ibrahim, Esraa K. Abd-alhameed & Emad H.M. Hassanein. (2023) Pharmacological updates of nifuroxazide: Promising preclinical effects and the underlying molecular mechanisms. European Journal of Pharmacology 951, pages 175776.
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Hala M.F. Mohammad, Sahar Galal Gouda, Mohamed Ahmed Eladl, Amany Y. Elkazaz, Khaled S. Elbayoumi, Noha E. Farag, Amr Elshormilisy, Buthainah B. Al-Ammash, Ann Hegazy, Sozan M. Abdelkhalig, Abir S. Mohamed, Mohamed El-Dosoky & Sawsan A. Zaitone. (2023) Metformin suppresses LRG1 and TGFβ1/ALK1-induced angiogenesis and protects against ultrastructural changes in rat diabetic nephropathy. Biomedicine & Pharmacotherapy 158, pages 114128.
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Tommaso Ceruti, Quintino Giorgio D’Alessandris, Roberta Frapolli, Jay Gopalakrishnan, Mariachiara Buccarelli, Marina Meroni, Liverana Lauretti, Lucia Ricci-Vitiani, Roberto Pallini & Massimo Zucchetti. (2022) Development and Validation of a HPLC–MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice. Pharmaceutics 14:10, pages 2071.
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Cailing Gan, Qianyu Zhang, Hongyao Liu, Guan Wang, Liqun Wang, Yali Li, Zui Tan, Wenya Yin, Yuqin Yao, Yongmei Xie, Liang Ouyang, Luoting Yu & Tinghong Ye. (2022) Nifuroxazide ameliorates pulmonary fibrosis by blocking myofibroblast genesis: a drug repurposing study. Respiratory Research 23:1.
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Mohamed El-Sherbiny, Rehab M. El-Sayed, Mohamed A. Helal, Afaf T. Ibrahiem, Hoda S. Elmahdi, Mohamed Ahmed Eladl, Shymaa E. Bilay, Asma M. Alshahrani, Mona K. Tawfik, Ziad E. Hamed, Amany O. Mohamed & Sawsan A. Zaitone. (2021) Nifuroxazide Mitigates Angiogenesis in Ehlrich’s Solid Carcinoma: Molecular Docking, Bioinformatic and Experimental Studies on Inhibition of Il-6/Jak2/Stat3 Signaling. Molecules 26:22, pages 6858.
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Fares E.M. Ali, Mohamed M. Elfiky, Walaa A. Fadda, Howaida S. Ali, Amany Refaat Mahmoud, Zuhair M. Mohammedsaleh & Tarek Hamdy Abd-Elhamid. (2021) Regulation of IL-6/STAT-3/Wnt axis by nifuroxazide dampens colon ulcer in acetic acid-induced ulcerative colitis model: Novel mechanistic insight. Life Sciences 276, pages 119433.
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Nabila M.E. Hassan, Eman Said & George S.G. Shehatou. (2021) Nifuroxazide suppresses UUO-induced renal fibrosis in rats via inhibiting STAT-3/NF-κB signaling, oxidative stress and inflammation. Life Sciences 272, pages 119241.
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Suliman Y. Alomar, Bassant M. Barakat, Mohamed Eldosoky, Hoda Atef, Abdelaty Shawky Mohamed, Reda Elhawary, Mohamed El-Shafey, Amal M. Youssef, Amany Y. Elkazaz, Attia M. Gabr, Abdelhakeem A. Elaskary, Mohamed A.K. Salih, Sultan Othman Alolayan & Sawsan A. Zaitone. (2021) Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity. International Immunopharmacology 90, pages 107193.
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Mahrokh Samadi, Shiva Gholizadeh-Ghaleh Aziz & Roya Naderi. (2020) The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats. Cell Stress and Chaperones 26:1, pages 217-227.
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Sharifa Alzahrani, Sawsan A. Zaitone, Eman Said, Mohamed El-Sherbiny, Sadeem Ajwah, Sumayyah Yasser Alsharif & Nehal M. Elsherbiny. (2020) Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NFκB balance and NLRP3 expression. International Immunopharmacology 87, pages 106813.
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Yousra M. El-Far, Nehal M. Elsherbiny, Mohamed El-Shafey & Eman Said. (2020) The interplay of the inhibitory effect of nifuroxazide on NF-κB/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in rats. Environmental Toxicology and Pharmacology 79, pages 103433.
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Ahmed E. Khodir, Yara A. Samra & Eman Said. (2020) A novel role of nifuroxazide in attenuation of sepsis-associated acute lung and myocardial injuries; role of TLR4/NLPR3/IL-1β signaling interruption. Life Sciences 256, pages 117907.
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Ahmed E. Khodir & Eman Said. (2020) Nifuroxazide attenuates experimentally-induced hepatic encephalopathy and the associated hyperammonemia and cJNK/caspase-8/TRAIL activation in rats. Life Sciences 252, pages 117610.
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Kavya Jash, Piyush Gondaliya, Prathibha Kirave, Bhagyashri Kulkarni, Aditya Sunkaria & Kiran Kalia. (2020) Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease. Drug Development Research 81:2, pages 144-164.
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Jing-Yi Liu, Yi-Chen Zhang, Li-Ni Song, Lin Zhang, Fang-Yuan Yang, Xiao-Rong Zhu, Zhi-Qiang Cheng, Xi Cao & Jin-Kui Yang. (2019) Nifuroxazide ameliorates lipid and glucose metabolism in palmitate-induced HepG2 cells. RSC Advances 9:67, pages 39394-39404.
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Nehal M. Elsherbiny, Eman Ahmed, Ghada Abdel Kader, Yousra Abdel-mottaleb, Mohamed H. ElSayed, Amal M. Youssef & Sawsan A. Zaitone. (2019) Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators. International Immunopharmacology 70, pages 16-27.
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Sheng-lei Yan, Zhi-hong Wang, Mei-chin Mong, Ya-chen Yang & Mei-chin Yin. (2019) Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice than individual treatments of carnosine or asiatic acid alone. Food and Chemical Toxicology 126, pages 192-198.
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Yu-Si Cheng, Jie Chao, Chen Chen, Lin-Li Lv, Yu-Chen Han & Bi-Cheng Liu. (2019) The PKCβ-p66shc-NADPH oxidase pathway plays a crucial role in diabetic nephropathy. Journal of Pharmacy and Pharmacology 71:3, pages 338-347.
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