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Toxicology Mechanisms and Methods Volume 30, 2020 - Issue 1
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Original Articles

Psoralen induces hepatic toxicity through PERK and ATF6 related ER stress pathways in HepG2 cells

Yingli YuInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; ;Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin, China; View further author information
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Ruili YuInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; View further author information
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Weijie MenInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; View further author information
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Panyang ZhangInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; View further author information
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Yue ZhangInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; ;Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin, China; View further author information
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Lei SongInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; ;Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin, China; View further author information
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Kun ZhouInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; ;Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin, China; ;Key Laboratory of Formula of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Ministry of Education, Tianjin, ChinaCorrespondence[email protected] [email protected]
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Pages 39-47 | Received 10 May 2019, Accepted 24 Jul 2019, Published online: 20 Aug 2019

Citations (18)

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Read on this site (1)

Ruili Yu, Yingli Yu, Shijia Su, Lin Zhao, Qin Wang, Yue Zhang, Lei Song & Kun Zhou. (2022) Psoralen induces liver injuries through endoplasmic reticulum stress signaling in female mice. Drug and Chemical Toxicology 45:4, pages 1818-1824.
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Articles from other publishers (17)

Benyu Liu, Shiming Fang, Kun Zhou, Lulu Ma, Yaling Shi, Yuefei Wang & Xiumei Gao. (2023) Unveiling hepatotoxicity distinction of coumarin-related compounds from glycosides to aglycones in Fructus Psoraleae by integrating UPLC-Q-TOF-MS and high content analysis. Journal of Ethnopharmacology 315, pages 116664.
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Linqi Ouyang, Zhiqiang Fan, Yang He, Long Tan, Guoyan Deng, Qin He, Yiran He, Ting Ouyang, Congjie Li, Qin Zhang, Hongyu Liu & Yajie Zuo. (2023) 4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L. Toxicology Letters 385, pages 31-41.
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Chao Tang, Jiaqi Han, Dan Chen, Shuai Zong, Jun Liu, Juan Kan, Chunlu Qian & Changhai Jin. (2023) Recent advances on the biological activities of purple sweet potato anthocyanins. Food Bioscience 53, pages 102670.
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Zhaojuan Guo, Yuanyuan Shi, Bingqian Jiang, Xiyi Peng, Lin Zhang, Can Tu & Ting Wang. (2023) Psoraleae Fructus Ethanol Extract Induced Hepatotoxicity via Impaired Lipid Metabolism Caused by Disruption of Fatty Acid β-Oxidation. Oxidative Medicine and Cellular Longevity 2023, pages 1-17.
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Tingting Liu, Guang Xu, Yurong Li, Wei Shi, Lutong Ren, Zhie Fang, Longxin Liang, Yan Wang, Yuan Gao, Xiaoyan Zhan, Qiang Li, Wenqing Mou, Li Lin, Ziying Wei, Zhiyong Li, Wenzhang Dai, Jia Zhao, Hui Li, Jiabo Wang, Yanling Zhao, Xiaohe Xiao & Zhaofang Bai. (2022) Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity. Journal of Ethnopharmacology 298, pages 115593.
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Zhuo SHI, Jing GAO, Jinchao PAN, Zuqi ZHANG, Guangchen ZHANG, Yuguang WANG & Yue GAO. (2022) A systematic review on the safety of Psoraleae Fructus: potential risks, toxic characteristics, underlying mechanisms and detoxification methods. Chinese Journal of Natural Medicines 20:11, pages 805-813.
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Lin Zhao, Yingli Yu, Li Li, Jiarui Wang, Jing Wang, Shijia Su, Jingyi Ding, Yue Zhang, Anhong Wang & Kun Zhou. (2022) Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression. Toxicon 216, pages 28-36.
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Yuan Wang, Jinfeng Cui, Guona Zheng, Man Zhao, Zengfang Hao, Hongguang Lian, Yuehong Li, Wenxin Wu, Xianghong Zhang & Juan Wang. (2022) Ochratoxin A induces cytotoxicity through ROS-mediated endoplasmic reticulum stress pathway in human gastric epithelium cells. Toxicology 479, pages 153309.
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Sitong Sun, Manshu Wang, Yu Yuan, Shuo Wang, Haoran Ding, Chenrui Liang, Xiaomeng Li, Simiao Fan & Yubo Li. (2022) A new strategy for the rapid identification and validation of direct toxicity targets of psoralen-induced hepatotoxicity. Toxicology Letters 363, pages 11-26.
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Zhaojuan Guo, Pin Li, Chunguo Wang, Qianjun Kang, Can Tu, Bingqian Jiang, Jingxuan Zhang, Weiling Wang & Ting Wang. (2021) Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis. Frontiers in Pharmacology 12.
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Liang Han, Yanhao Xu & Yuxiu Shi. (2021) Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of Molecular Neuroscience 71:12, pages 2487-2499.
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Lixia Yang, ZhengHong Chen, Jie Li, PengJin Ding & Yiming Wang. (2021) Effects of Escitalopram on Endoplasmic Reticulum Stress and Oxidative Stress Induced by Tunicamycin. Frontiers in Neuroscience 15.
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Juyang Huang, Qin Wang, Mengying Chen, Yanan Bi, Hong Shi & Kun Zhou. (2020) Effects of psoralen on hepatic bile acid transporters in rats. Human & Experimental Toxicology 40:6, pages 1012-1021.
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Yali Ren, Xiaominting Song, Lu Tan, Chuanjie Guo, Miao Wang, Hui Liu, Zhixing Cao, Yuzhi Li & Cheng Peng. (2020) A Review of the Pharmacological Properties of Psoralen. Frontiers in Pharmacology 11.
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Li Yang, Ying-li Yu, Li-yuan Cheng, Pan-yang Zhang, Yue Zhang & Kun Zhou. (2020) The Accumulation of Psoralen Contributes to Its Hepatotoxicity Revealed by Pharmacokinetic and Toxicokinetic Study after Repeated Administration. ACS Omega 5:13, pages 7307-7315.
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Qi-Hang ZHOU, Ya-Di ZHU, Feng ZHANG, Yun-Qing SONG, Shou-Ning JIA, Liang ZHU, Sheng-Quan FANG & Guang-Bo GE. (2019) Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus. Chinese Journal of Natural Medicines 17:11, pages 858-870.
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Tingting Liu, Xu Guang, Li Yurong, Shi Wei, Ren Lutong, Fang Zhie, Liang Longxin, Wang Yan, Gao Yuan, Zhan Xiaoyan, Li Qiang, Mou Wenqing, Lin Li, Wei Ziying, Li Zhiyong, Dai Wenzhang, Zhao Jia, Li Hui, Wang Jiabo, Zhao Yanling, Xiao Xiaohe & Bai Zhaofang. (2022) Discovery of Bakuchiol as Aim2 Inflammasome Activator and Cause Hepatotoxicity. SSRN Electronic Journal.
Crossref

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