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Original Articles

Zinc abrogates anticancer drug tamoxifen-induced hepatotoxicity by suppressing redox imbalance, NO/iNOS/NF-ĸB signaling, and caspase-3-dependent apoptosis in female rats

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Pages 115-123 | Received 05 Jun 2019, Accepted 09 Sep 2019, Published online: 01 Oct 2019

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Read on this site (2)

Sangeetha Nithiyanandam & Sabina Evan Prince. (2021) Toxins mechanism in instigating hepatotoxicity. Toxin Reviews 40:4, pages 616-631.
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Articles from other publishers (17)

Gellan Alaa Mohamed Kamel & Hemat A. Elariny. (2023) Pioglitazone attenuates tamoxifen-induced liver damage in rats via modulating Keap1/Nrf2/HO-1 and SIRT1/Notch1 signaling pathways: In-vivo investigations, and molecular docking analysis. Molecular Biology Reports 50:12, pages 10219-10233.
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Maisa Siddiq Abduh, Sultan Ayesh Mohammed Saghir, Naif Ahmed Al-Gabri, Ahmad Faheem Ahmeda, Mouaadh Abdelkarim, Saleh Mohammad Aldaqal & Mohammed Abdullah Alshawsh. (2023) Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats. Saudi Journal of Biological Sciences 30:10, pages 103806.
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Shahrzad Molavinia, Mehrnoosh Moosavi, Sara Hejazi, Reza Azadnasab, Esrafil Mansouri & Mohammad Javad Khodayar. (2023) Metformin alleviates sodium arsenite‐induced hepatotoxicity and glucose intolerance in mice by suppressing oxidative stress, inflammation, and apoptosis. Journal of Trace Elements in Medicine and Biology, pages 127299.
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Morgane Davezac, Cecile Meneur, Melissa Buscato, Rana Zahreddine, Jean-François Arnal, Florence Dalenc, Françoise Lenfant & Coralie Fontaine. (2023) The beneficial effects of tamoxifen on arteries: A key player for cardiovascular health of breast cancer patient. Biochemical Pharmacology 214, pages 115677.
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Farid Khallouki, Lhoussain Hajji, Somayya Saber, Toufik Bouddine, Mouad Edderkaoui, Mohammed Bourhia, Nora Mir, Adrian Lim, Adil El Midaoui, John P. Giesy, Mourad A. M. Aboul-Soud, Sandrine Silvente-Poirot & Marc Poirot. (2023) An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management. Journal of Personalized Medicine 13:5, pages 754.
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Elias Adikwu & Bonsome Bokolo. (2022) Therapeutic benefit of ursodeoxycholic acid in tamoxifen-induced hepatotoxicity in Wistar rats. Journal of Medical Science 91:4, pages e743.
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Meichen Gao, Naixi Yang, Yutian Lei, Wenyue Zhang, Huanyi Liu & Hongjin Lin. (2022) Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function. Fish & Shellfish Immunology 131, pages 1075-1084.
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Enas A. Abd El‐Haleim & Nada A. Sallam. (2021) Vitamin D modulates hepatic microRNAs and mitigates tamoxifen‐induced steatohepatitis in female rats. Fundamental & Clinical Pharmacology 36:2, pages 338-349.
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Preeti Sharma, Younis Ahmad Hajam, Rajesh Kumar & Seema Rai. (2022) Complementary and alternative medicine for the treatment of diabetes and associated complications: A review on therapeutic role of polyphenols. Phytomedicine Plus 2:1, pages 100188.
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Nermin S. Ahmed, Marek Samec, Alena Liskova, Peter Kubatka & Luciano Saso. (2021) Tamoxifen and oxidative stress: an overlooked connection. Discover Oncology 12:1.
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Ebuka E. David, Muhammad A. Yameen, Ikechuku O. Igwenyi & Chidinma N. David. (2021) Zinc-fortification restores gut nitric oxide without expression of inducible nitric oxide synthase gene in enterotoxigenic E. coli-induced diarrhea in zinc-deficient rats. Scientific African 13, pages e00867.
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Aliah R. Alshanwani, Azza M. Mohamed, Laila M. Faddah, Sameerah Shaheen, Maha M. Arafah, Hanan Hagar, Ahlam M. Alhusaini, Fatima M.B. Alharbi, Alaa AlHarthii & Amira M. Badr. (2021) Cyanocobalamin and/or calcitriol mitigate renal damage-mediated by tamoxifen in rats: Implication of caspase-3/NF-κB signaling pathways. Life Sciences 277, pages 119512.
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Peng Song, Chen Sun, Jinbo Li, Tong Long, Yixin Yan, Hongping Qin, Emmanuel Ayobami Makinde, Ademola C Famurewa, Amit Jaisi, Ying Nie & Opeyemi Joshua Olatunji. (2020) Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro‐inflammatory responses in rats . Journal of the Science of Food and Agriculture 101:4, pages 1598-1608.
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Elif Gulbahce-Mutlu, Saltuk Bugra Baltaci, Esma Menevse, Rasim Mogulkoc & Abdulkerim Kasim Baltaci. (2020) The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats. Biological Trace Element Research 199:3, pages 1044-1051.
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Ademola C. Famurewa, C.O. Edeogu, Florence I. Offor, Elizabeth E. Besong, Gabriel G. Akunna & Ekenechukwu K. Maduagwuna. (2021) Downregulation of redox imbalance and iNOS/NF-ĸB/caspase-3 signalling with zinc supplementation prevents urotoxicity of cyclophosphamide-induced hemorrhagic cystitis in rats. Life Sciences 266, pages 118913.
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Valeria R. Martínez, María V. Aguirre, Juan S. Todaro, Evelina G. Ferrer & Patricia A. M. Williams. (2021) Candesartan and valsartan Zn( ii ) complexes as inducing agents of reductive stress: mitochondrial dysfunction and apoptosis . New Journal of Chemistry 45:2, pages 939-951.
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Ademola C. Famurewa, Chima A. Ekeleme‐Egedigwe, Chikodili S. Onwe, Uchenna O. Egedigwe, Chukwuemeka O. Okoro, Ugochukwu J. Egedigwe & Nnaemeka T. Asogwa. (2020) Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats. Andrologia 52:10.
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