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Toxicology Mechanisms and Methods Volume 30, 2020 - Issue 8
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Original Articles

Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: impact on TGF-β/Smad3 and NF-κB signaling pathways

Ayah M. H. Gowifela Faculty of Pharmacy, Pharmacology and Toxicology Department, Modern University for Technology and Information, Cairo, Egypt
,
Mona G. Khalila Faculty of Pharmacy, Pharmacology and Toxicology Department, Modern University for Technology and Information, Cairo, Egypt
,
Somaia A. Nadab Pharmacology Department, National Research Centre, Giza, Egypt
,
Sanaa A. Kenawyc Faculty of Pharmacy, Pharmacology and Toxicology Department, Cairo University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5019-2838
ORCID Icon,
Kawkab A. Ahmedd Faculty of Veterinary Medicine, Pathology Department, Cairo University, Giza, Egypt
,
Maha M. Salamae Faculty of Pharmacy, Department of Pharmacognosy, Cairo University, Cairo, Egypt;f Faculty of Pharmacy, Department of Pharmacognosy, The British University in Egypt, Cairo, Egypt
&
Marwa M. Safarc Faculty of Pharmacy, Pharmacology and Toxicology Department, Cairo University, Cairo, Egypt;g Faculty of Pharmacy, Pharmacology and Biochemistry Department, The British University in Egypt, Cairo, Egypt
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Pages 620-633 | Received 15 Mar 2020, Accepted 22 Jul 2020, Published online: 19 Aug 2020

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Qiongdan Hu, Wan Liao, Zhen Zhang, Sanjun Shi, Shuguang Hou, Ningping Ji, Xinjie Zhang, Qian Zhang, Yangyang Liao, Linghui Li, Zongping Zhu, Yi Chen, Jiao Chen, Fangkun Yu, Qingsong Yang, Hongtao Xiao, Chaomei Fu, Hengjun Du, Qi Wang, Heping Cao, Hang Xiao & Rui Li. (2023) The hepatoprotective effects of plant-based foods based on the “gut–liver axis”: a prospective review. Critical Reviews in Food Science and Nutrition 63:28, pages 9136-9162.
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Articles from other publishers (15)

Ehsan Khedre Mohamed & Dawlat Mohamed Hafez. (2023) Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats. BMC Complementary Medicine and Therapies 23:1.
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Huanhuan Fei, Yao Qian, Tianyun Pan, Ying Wei & Yun Hu. (2023) Curcumin alleviates hypertrophic scarring by inhibiting fibroblast activation and regulating tissue inflammation. Journal of Cosmetic Dermatology.
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Amany A. Sayed, Amel M. Soliman, Mohamed Marzouk, Faten F. Mohammed & Shreen Desouky. (2023) Bromelain mitigates liver fibrosis via targeting hepatic stellate cells in vitro and in vivo. Tissue and Cell 82, pages 102118.
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Suhayla Hamad Shareef, Ameena S. M. Juma, Derin N. F. Agha, Abdullah R. Alzahrani, Ibrahim Abdel Aziz Ibrahim & Mahmood Ameen Abdulla. (2023) Hepatoprotective Effect of Alpinetin on Thioacetamide-Induced Liver Fibrosis in Sprague Dawley Rat. Applied Sciences 13:9, pages 5243.
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Devaraj Ezhilarasan. (2023) Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models. Environmental Toxicology and Pharmacology 99, pages 104093.
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Wenjuan Xu, Longde Wang, Yuanyuan Niu, Lanfang Mao, Xiaojuan Du, Ping Zhang, Zhengju Li, Hongfang Li & Ning Li. (2022) A review of edible plant-derived natural compounds for the therapy of liver fibrosis. European Journal of Gastroenterology & Hepatology 35:2, pages 133-152.
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Omayma AR. Abo-Zaid, Fatma SM Moawed, Effat Soliman Ismail & Esraa S.A. Ahmed. (2023) β-Sitosterol mitigates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced hepatic injury in γ-irradiated rats. Food and Chemical Toxicology 172, pages 113602.
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Suhayla H. Shareef, Morteta H. Al-Medhtiy, Ahmed S. Al Rashdi, Peshawa Y. Aziz & Mahmood A. Abdulla. (2023) Hepatoprotective effect of pinostrobin against thioacetamide-induced liver cirrhosis in rats. Saudi Journal of Biological Sciences 30:1, pages 103506.
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Mohammad Javad Emami Kazemabad, Sara Asgari Toni, Neda Tizro, Parisa Alsadat Dadkhah, Hanieh Amani, Shima Akhavan Rezayat, Zahra Sheikh, Mohammad Mohammadi, Dorsa Alijanzadeh, Farnoosh Alimohammadi, Mehregan Shahrokhi, Gisou Erabi, Masoud Noroozi, Mohammad Amin Karimi, Sara Honari & Niloofar Deravi. (2022) Pharmacotherapeutic potential of pomegranate in age-related neurological disorders. Frontiers in Aging Neuroscience 14.
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Yang Yang, Rengui Liu, Yuhua Qu, Jingyao Zhao, Linge Tong, Shengying Ye & Yan Qin. (2022) Ghrelin ameliorates transformation of hepatic ischemia-reperfusion injury to liver fibrosis by blocking Smad and ERK signalling pathways, and promoting anti-inflammation and anti-oxidation effects. Transplant Immunology 73, pages 101597.
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Sihong Li, Ruimeng Liu, Shun Xia, Gaoqiang Wei, Muhammad Ishfaq, Yixin Zhang & Xiuying Zhang. (2022) Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver. Ecotoxicology and Environmental Safety 233, pages 113319.
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Atef M. Al-Attar. (2022) Hematological and biochemical investigations on the effect of curcumin and Thymoquinone in male mice exposed to Thioacetamide. Saudi Journal of Biological Sciences 29:1, pages 660-665.
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Suhayla Hamad Shareef, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Morteta H. Al-Medhtiy & Mahmood Ameen Abdulla. (2022) Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats. Saudi Journal of Biological Sciences 29:1, pages 564-573.
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Wentao Jia, Shufang Liang, Binbin Cheng & Changquan Ling. (2021) The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment. Frontiers in Oncology 11.
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Mobarakeh Ghadiri, Vafa Baradaran Rahimi, Elham Moradi, Maede Hasanpour, Cain C. T. Clark, Mehrdad Iranshahi, Hassan Rakhshandeh & Vahid Reza Askari. (2021) Standardised pomegranate peel extract lavage prevents postoperative peritoneal adhesion by regulating TGF-β and VEGF levels. Inflammopharmacology 29:3, pages 855-868.
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