Advanced search
Publication Cover
Cancer Biology & Therapy Volume 16, 2015 - Issue 5
Submit an article Journal homepage
1,020
Views
19
CrossRef citations to date
0
Altmetric
Research Paper

PRIMA-1Met induces apoptosis in Waldenström's Macroglobulinemia cells independent of p53

Mona SobhaniDivision of Molecular and Cellular Biology; Toronto General Hospital Research Institute; Toronto, Ontario, Canada;Dept. of Laboratory Medicine & Pathobiology; University of Toronto; Toronto, Ontario, Canada
,
Jahangir AbdiDivision of Molecular and Cellular Biology; Toronto General Hospital Research Institute; Toronto, Ontario, Canada;Dept. of Laboratory Medicine & Pathobiology; University of Toronto; Toronto, Ontario, Canada
,
Saha N ManujendraDivision of Molecular and Cellular Biology; Toronto General Hospital Research Institute; Toronto, Ontario, Canada;Dept. of Laboratory Medicine & Pathobiology; University of Toronto; Toronto, Ontario, Canada
,
Christine ChenDept. of Laboratory Hematology and Medical Oncology; University Health Network; Toronto, Ontario, Canada
&
Hong ChangDivision of Molecular and Cellular Biology; Toronto General Hospital Research Institute; Toronto, Ontario, Canada;Dept. of Laboratory Medicine & Pathobiology; University of Toronto; Toronto, Ontario, Canada;Dept. of Laboratory Hematology and Medical Oncology; University Health Network; Toronto, Ontario, CanadaCorrespondence[email protected]
Pages 799-806 | Received 15 Dec 2014, Accepted 01 Mar 2015, Published online: 21 May 2015

Citations (19)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Marte Karen Brattås, Håkon Reikvam, Tor Henrik Anderson Tvedt & Øystein Bruserud. (2019) Precision medicine for TP53-mutated acute myeloid leukemia. Expert Review of Precision Medicine and Drug Development 4:5, pages 263-274.
Read now

Articles from other publishers (18)

Ibtehal Mohammed, Ali Haider Alhammer & Inam Sameh Arif. (2023) The p53 reactivator PRIMA-1MET synergises with 5-fluorouracil to induce apoptosis in pancreatic cancer cells. Investigational New Drugs.
Crossref
Yuheng Hong, Tianyuan Ren, Xiaoxuan Wang, Xia Liu, Yue Fei, Shen Meng, Xu Han, Cong Sun, Hongru Shen, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Huilai Zhang & Xianhuo Wang. (2022) APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations. Leukemia 36:9, pages 2269-2280.
Crossref
Lorena Verduci, Emilio Tarcitano, Sabrina Strano, Yosef Yarden & Giovanni Blandino. (2021) CircRNAs: role in human diseases and potential use as biomarkers. Cell Death & Disease 12:5.
Crossref
Sophia Ceder, Sofi E Eriksson, Emarndeena H Cheteh, Swati Dawar, Mariana Corrales Benitez, Vladimir J N Bykov, Kenji M Fujihara, Mélodie Grandin, Xiaodun Li, Susanne Ramm, Corina Behrenbruch, Kaylene J Simpson, Frédéric Hollande, Lars Abrahmsen, Nicholas J Clemons & Klas G Wiman. (2020) A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death. EMBO Molecular Medicine 13:2.
Crossref
Suganthapriya Elayapillai, Satishkumar Ramraj, Doris Mangiaracina Benbrook, Magdalena Bieniasz, Lin Wang, Gopal Pathuri, Zitha Redempta Isingizwe, Amy L. Kennedy, Yan D. Zhao, Stanley Lightfoot, Lauri A. Hunsucker & Camille C. Gunderson. (2021) Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer. Gynecologic Oncology 160:1, pages 302-311.
Crossref
Zuzana Jaskova, Sarka Pavlova, Jitka Malcikova, Yvona Brychtova & Martin Trbusek. (2020) PRIMA-1MET cytotoxic effect correlates with p53 protein reduction in TP53-mutated chronic lymphocytic leukemia cells. Leukemia Research 89, pages 106288.
Crossref
Elizabeth Lieschke, Zilu Wang, Gemma L Kelly & Andreas Strasser. (2019) Discussion of some ‘knowns’ and some ‘unknowns’ about the tumour suppressor p53. Journal of Molecular Cell Biology 11:3, pages 212-223.
Crossref
Michael J. Duffy, Naoise C. Synnott & John Crown. (2018) Mutant p53 in breast cancer: potential as a therapeutic target and biomarker. Breast Cancer Research and Treatment 170:2, pages 213-219.
Crossref
Toshimichi Tanaka, Masahiko Watanabe & Keishi Yamashita. (2018) Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer . Oncotarget 9:22, pages 16234-16247.
Crossref
Vladimir J. N. Bykov, Sofi E. Eriksson, Julie Bianchi & Klas G. Wiman. (2017) Targeting mutant p53 for efficient cancer therapy. Nature Reviews Cancer 18:2, pages 89-102.
Crossref
Anne Perdrix, Ahmad Najem, Sven Saussez, Ahmad Awada, Fabrice Journe, Ghanem Ghanem & Mohammad Krayem. (2017) PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies. Cancers 9:12, pages 172.
Crossref
Daniel Nguyen, Wenjuan Liao, Shelya X. Zeng & Hua Lu. (2017) Reviving the guardian of the genome: Small molecule activators of p53. Pharmacology & Therapeutics 178, pages 92-108.
Crossref
Michael J. Duffy, Naoise C. Synnott & John Crown. (2017) Mutant p53 as a target for cancer treatment. European Journal of Cancer 83, pages 258-265.
Crossref
Maria Ferraiuolo, Lorena Verduci, Giovanni Blandino & Sabrina Strano. (2017) Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers. International Journal of Molecular Sciences 18:5, pages 961.
Crossref
Andreas C. JoergerAlan R. Fersht. (2016) The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches. Annual Review of Biochemistry 85:1, pages 375-404.
Crossref
Maria Ferraiuolo, Silvia Di Agostino, Giovanni Blandino & Sabrina Strano. (2016) Oncogenic Intra-p53 Family Member Interactions in Human Cancers. Frontiers in Oncology 6.
Crossref
Thomas Grellety, Audrey Laroche-Clary, Vanessa Chaire, Pauline Lagarde, Frédéric Chibon, Agnes Neuville & Antoine Italiano. (2015) PRIMA-1MET induces death in soft-tissue sarcomas cell independent of p53. BMC Cancer 15:1.
Crossref
Cui-xia Di, Lu Han, Hong Zhang, Shuai Xu, Ai-hong Mao, Chao Sun, Yang Liu, Jing Si, Hong-yan Li, Xin Zhou, Bing Liu & Guo-ying Miao. (2015) Diallyl disulfide attenuated carbon ion irradiation-induced apoptosis in mouse testis through changing the ratio of Tap73/ΔNp73 via mitochondrial pathway. Scientific Reports 5:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.