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Cancer Biology & Therapy Volume 16, 2015 - Issue 9
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Research Papers

A targeted IL-15 fusion protein with potent anti-tumor activity

Siqi ChenSchool of Pharmaceutical Sciences; Sun Yat-Sen University; Guangzhou, PR China;Centre for Cellular & Structural Biology; Sun Yat-Sen University; Guangzhou, PR China
,
Qiang HuangSchool of Pharmaceutical Sciences; Sun Yat-Sen University; Guangzhou, PR China;Centre for Cellular & Structural Biology; Sun Yat-Sen University; Guangzhou, PR China
,
Jiayu LiuSchool of Pharmaceutical Sciences; Sun Yat-Sen University; Guangzhou, PR China;Centre for Cellular & Structural Biology; Sun Yat-Sen University; Guangzhou, PR China
,
Jieyu XingSchool of Pharmaceutical Sciences; Sun Yat-Sen University; Guangzhou, PR China;Centre for Cellular & Structural Biology; Sun Yat-Sen University; Guangzhou, PR China
,
Ning ZhangPeking University Cancer Hospital; Beijing Institute for Cancer Research; Beijing, PR China
,
Yawei LiuHealth Division of Guard Bureau; General Staff Department of PLA; Beijing, PR China
,
Zhong WangSchool of Pharmaceutical Sciences; Sun Yat-Sen University; Guangzhou, PR China;Centre for Cellular & Structural Biology; Sun Yat-Sen University; Guangzhou, PR ChinaCorrespondence[email protected]
&
Qing LiSchool of Pharmaceutical Sciences; Sun Yat-Sen University; Guangzhou, PR China;Centre for Cellular & Structural Biology; Sun Yat-Sen University; Guangzhou, PR China
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Pages 1415-1421 | Received 29 Apr 2015, Accepted 04 Jul 2015, Published online: 20 Aug 2015

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Mohammad Rasoolian, Majid Kheirollahi & Seyed Younes Hosseini. (2019) MDA-7/interleukin 24 (IL-24) in tumor gene therapy: application of tumor penetrating/homing peptides for improvement of the effects. Expert Opinion on Biological Therapy 19:3, pages 211-223.
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Yue Liu, Yanlan Wang, Jieyu Xing, Yumei Li, Jiayu Liu & Zhong Wang. (2018) A novel multifunctional anti-CEA-IL15 molecule displays potent antitumor activities. Drug Design, Development and Therapy 12, pages 2645-2654.
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Elena García-Martínez, Melody Smith, Aitziber Buqué, Fernando Aranda, Francisco Ayala de la Peña, Alejandra Ivars, Manuel Sanchez Cánovas, Ma Angeles Vicente Conesa, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2018) Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy. OncoImmunology 7:6.
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Siqi Chen, Jing Li, Qing Li & Zhong Wang. (2016) Bispecific antibodies in cancer immunotherapy. Human Vaccines & Immunotherapeutics 12:10, pages 2491-2500.
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Articles from other publishers (9)

Jihong Chen, Ziyou Shen, Xiaoling Jiang, Zhenzhen Huang, Chongbing Wu, Dongcheng Jiang & Liusong Yin. (2023) Preclinical evaluation of IAP0971, a novel immunocytokine that binds specifically to PD1 and fuses IL15/IL15R α complex . Antibody Therapeutics 6:1, pages 38-48.
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Yumei Li, Lingjun Wu, Yueying Liu, Siwen Ma, Biyi Huang, Xianjing Feng & Hui Wang. (2022) A novel multifunctional anti-PD-L1-CD16a-IL15 induces potent cancer cell killing in PD-L1-positive tumour cells. Translational Oncology 21, pages 101424.
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Patrick G. Holder, Shion A. Lim, Christine S. Huang, Preeti Sharma, Yavuz S. Dagdas, Beyza Bulutoglu & Jonathan T. Sockolosky. (2022) Engineering interferons and interleukins for cancer immunotherapy. Advanced Drug Delivery Reviews 182, pages 114112.
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Xiaohu Zheng, Yaqi Wu, Jiacheng Bi, Yingying Huang, Ying Cheng, Yangyang Li, Yuwei Wu, Guoshuai Cao & Zhigang Tian. (2022) The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy. Cellular & Molecular Immunology 19:2, pages 192-209.
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Huilin Yang, Rakeeb Kureshi & Jamie B. Spangler. 2019. Structural Immunology. Structural Immunology 1 19 .
Changhua Zhou, Jing Li, Limin Lin, Rui Shu, Bin Dong, Donglin Cao, Qing Li & Zhong Wang. (2018) A targeted transforming growth factor-beta (TGF-β) blocker, TTB, inhibits tumor growth and metastasis. Oncotarget 9:33, pages 23102-23113.
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Xiaoqiong Wu, Siqi Chen, Limin Lin, Jiayu Liu, Yanlan Wang, Yumei Li, Qing Li & Zhong Wang. (2018) A Single Domain–Based Anti-Her2 Antibody Has Potent Antitumor Activities. Translational Oncology 11:2, pages 366-373.
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Renee N. Donahue, Lauren M. Lepone, Italia Grenga, Caroline Jochems, Massimo Fantini, Ravi A. Madan, Christopher R. Heery, James L. Gulley & Jeffrey Schlom. (2017) Analyses of the peripheral immunome following multiple administrations of avelumab, a human IgG1 anti-PD-L1 monoclonal antibody. Journal for ImmunoTherapy of Cancer 5:1.
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Jieyu Xing, Limin Lin, Jing Li, Jiayu Liu, Changhua Zhou, Haitao Pan, Rui Shu, Bin Dong, Donglin Cao, Qing Li & Zhong Wang. (2017) BiHC, a T-Cell–Engaging Bispecific Recombinant Antibody, Has Potent Cytotoxic Activity Against Her2 Tumor Cells. Translational Oncology 10:5, pages 780-785.
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