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Cancer Biology & Therapy Volume 17, 2016 - Issue 6
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Research Paper

Iron depletion enhances the effect of sorafenib in hepatocarcinoma

Shinichi UranoDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Toshiaki OharaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;Department of Pathology & Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanCorrespondence[email protected]
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Kazuhiro NomaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Ryoichi KatsubeDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Takayuki NinomiyaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Yasuko TomonoShigei Medical Research Institute, Okayama, Japan
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Hiroshi TazawaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan
,
Shunsuke KagawaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Yasuhiro ShirakawaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Fumiaki KimuraDepartment of Internal Medicine, Tamano City Hospital, Okayama, Japan
,
Kazuhiro NousoDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Akihiro MatsukawaDepartment of Pathology & Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
,
Kazuhide YamamotoDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
&
Toshiyoshi FujiwaraDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanCorrespondence[email protected]
 show all
Pages 648-656 | Received 01 Dec 2015, Accepted 08 Apr 2016, Published online: 17 Jun 2016

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Wan-Atirah Azemin, Nadiawati Alias, Abdul Manaf Ali & Mohd Shahir Shamsir. (2023) Structural and functional characterisation of HepTH1-5 peptide as a potential hepcidin replacement. Journal of Biomolecular Structure and Dynamics 41:2, pages 681-704.
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Hao Liao, Juanyi Shi, Kai Wen, Jianhong Lin, Qinghua Liu, Bingchao Shi, Yongcong Yan & Zhiyu Xiao. (2021) Molecular Targets of Ferroptosis in Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma 8, pages 985-996.
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Articles from other publishers (16)

Zelong Gao, Dongyao Wang, Jianxin Yang, Min Li, Changquan Ling, Diya Lv, Yan Cao, Zhenyu Chen, Ce Shi, Hui Shen & Yuxiao Tang. (2023) Iron deficiency in hepatocellular carcinoma cells induced sorafenib resistance by upregulating HIF-1α to inhibit apoptosis. Biomedicine & Pharmacotherapy 163, pages 114750.
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Nikolaos-Andreas Anastasopoulos, Antonia V. Charchanti, Alexandra Barbouti, Eleftheria M. Mastoridou, Anna C. Goussia, Anastasia D. Karampa, Dimitrios Christodoulou & Georgios K. Glantzounis. (2023) The Role of Oxidative Stress and Cellular Senescence in the Pathogenesis of Metabolic Associated Fatty Liver Disease and Related Hepatocellular Carcinoma. Antioxidants 12:6, pages 1269.
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Yun Ye, Jing Xie, Lina Wang, Cong He & Youwen Tan. (2023) Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report. Open Medicine 18:1.
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Haoran Zheng, Fan Yang, Kaige Deng, Jiaxin Wei, Zhenting Liu, Yong-Chang Zheng & Haifeng Xu. (2023) Relationship between iron overload caused by abnormal hepcidin expression and liver disease: A review. Medicine 102:11, pages e33225.
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Yuze Wang, Toshiaki Ohara, Yuehua Chen, Yusuke Hamada, Chunning Li, Masayoshi Fujisawa, Teizo Yoshimura & Akihiro Matsukawa. (2023) Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators. Cancers 15:2, pages 468.
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传兴 翟. (2023) Research Advances in Cell Death in Osteoarthritis. Advances in Clinical Medicine 13:03, pages 4454-4458.
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Marjan Abedi & Soheila Rahgozar. (2022) Puzzling out iron complications in cancer drug resistance. Critical Reviews in Oncology/Hematology 178, pages 103772.
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Wataru Jomen, Takaaki Ohtake, Takayuki Akita, Daisuke Suto, Hideki Yagi, Yosuke Osawa & Yutaka Kohgo. (2022) Iron chelator deferasirox inhibits NF-κB activity in hepatoma cells and changes sorafenib-induced programmed cell deaths. Biomedicine & Pharmacotherapy 153, pages 113363.
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Jian Yang, Shasha Hu, Yangyang Bian, Jiangling Yao, Dong Wang, Xiaoqian Liu, Zhengdong Guo, Siyuan Zhang & Lei Peng. (2022) Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis. Frontiers in Cell and Developmental Biology 9.
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Si-Jia Wu, Zun-Zhen Zhang, Nan-Sheng Cheng, Xian-Ze Xiong & Luo Yang. (2019) Preoperative serum ferritin is an independent prognostic factor for liver cancer after hepatectomy. Surgical Oncology 29, pages 159-167.
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Toshiaki Ohara, Yasuko Tomono, Xing Boyi, Sun Yingfu, Kazuhiro Omori & Akihiro Matsukawa. (2018) A novel, nontoxic iron chelator, super-polyphenol, effectively induces apoptosis in human cancer cell lines. Oncotarget 9:67, pages 32751-32760.
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Ufuk OZER. (2018) Breast Cancer Stem Cells and Iron Dependency. Dicle Tıp Dergisi 45:2, pages 195-200.
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Yanyan Wei, Wei Ye & Wei Zhao. (2018) Serum Iron Levels Decreased in Patients with HBV-Related Hepatocellular Carcinoma, as a Risk Factor for the Prognosis of HBV-Related HCC. Frontiers in Physiology 9.
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Driton Vela & Zana Vela-Gaxha. (2018) Differential regulation of hepcidin in cancer and non-cancer tissues and its clinical implications. Experimental & Molecular Medicine 50:2, pages e436-e436.
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Takayuki Ninomiya, Toshiaki Ohara, Kazuhiro Noma, Yuki Katsura, Ryoichi Katsube, Hajime Kashima, Takuya Kato, Yasuko Tomono, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Fumiaki Kimura, Ling Chen, Tomonari Kasai, Masaharu Seno, Akihiro Matsukawa & Toshiyoshi Fujiwara. (2017) Iron depletion is a novel therapeutic strategy to target cancer stem cells. Oncotarget 8:58, pages 98405-98416.
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Issei Saeki, Naoki Yamamoto, Takahiro Yamasaki, Taro Takami, Masaki Maeda, Koichi Fujisawa, Takuya Iwamoto, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Koichi Uchida, Kenji Tani & Isao Sakaida. (2016) Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma. World Journal of Gastroenterology 22:40, pages 8967.
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