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Cancer Biology & Therapy Volume 18, 2017 - Issue 5
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Research Paper

Ameliorative effects of pyrazinoic acid against oxidative and metabolic stress manifested in rats with dimethylhydrazine induced colonic carcinoma

Anil K. SahdevDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, India
,
Vinit RajDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, India
,
Ashok K. SinghDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, India
,
Amit RaiDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, India
,
Amit K. KeshariDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, India
,
Arnab DeDepartment of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
,
Amalesh SamantaDepartment of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
,
Umesh KumarCentre of Biomedical Research, SGPGIMS Campus, Lucknow, Uttar Pradesh, India
,
Atul RawatCentre of Biomedical Research, SGPGIMS Campus, Lucknow, Uttar Pradesh, India;Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, India
,
Dinesh KumarCentre of Biomedical Research, SGPGIMS Campus, Lucknow, Uttar Pradesh, India
,
Sneha NathDepartment of Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, India
,
Anand PrakashDepartment of Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, India
&
Sudipta SahaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, IndiaCorrespondence[email protected]
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Pages 304-313 | Received 27 Oct 2016, Accepted 19 Mar 2017, Published online: 16 May 2017

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Pranesh Kumar, Anurag Kumar Gautam, Umesh Kumar, Archana S. Bhadauria, Ashok K. Singh, Dinesh Kumar, Tarun Mahata, Biswanath Maity, Hriday Bera & Sudipta Saha. (2022) Mechanistic exploration of the activities of poly(lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid against hepatocellular carcinoma at cellular and molecular levels. Archives of Physiology and Biochemistry 128:3, pages 836-848.
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Amit K Keshari, Ashok K Singh, Umesh Kumar, Vinit Raj, Amit Rai, Pranesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash & Sudipta Saha. (2017) 5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction. Drug Design, Development and Therapy 11, pages 2981-2995.
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Geeta Mishra, Parmesh K. Dwivedi, Neeraj Verma, Sajal Srivastava, Ashok K Singh & Devdutt Chaturvedi. (2023) Cu(II) and Fe(III) Catalyzed Synthesis of Novel Thiophene Hybridized Thiadiazolyl Schiff Bases (TTS) as COX-2 Selective Inhibitor. Asian Journal of Chemistry 35:6, pages 1518-1524.
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Shiva Akhlaghi, Azar Mostoufi, Hadi Kalantar & Masood Fereidoonnezhad. (2022) Synthesis and biological evaluations of novel pyrazinoic acid derivatives as anticancer agents. Medicinal Chemistry Research 31:4, pages 580-593.
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Raghda T. Abdel-Latif, Walaa Wadie, Yousra Abdel-mottaleb, Dalaal M. Abdallah, Nabila N. El-Maraghy & Hanan S. El-Abhar. (2022) Reposition of the anti-inflammatory drug diacerein in an in-vivo colorectal cancer model. Saudi Pharmaceutical Journal 30:1, pages 72-90.
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Nader H. Moniri & Qadan Farah. (2021) Short-chain free-fatty acid G protein-coupled receptors in colon cancer. Biochemical Pharmacology 186, pages 114483.
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Raquibun Nisha, Pranesh Kumar, Umesh Kumar, Nidhi Mishra, Priyanka Maurya, Samipta Singh, Priya Singh, Anupam Guleria, Sudipta Saha & Shubhini A Saraf. (2020) Fabrication of Imatinib Mesylate-Loaded Lactoferrin-Modified PEGylated Liquid Crystalline Nanoparticles for Mitochondrial-Dependent Apoptosis in Hepatocellular Carcinoma. Molecular Pharmaceutics 18:3, pages 1102-1120.
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Sara Shojaei-Zarghani, Maryam Rafraf, Ahmad Yari Khosroushahi & Shirin Sheikh-Najafi. (2020) Effectiveness of theobromine on inhibition of 1,2-dimethylhydrazine-induced rat colon cancer by suppression of the Akt/GSK3β/β-catenin signaling pathway. Journal of Functional Foods 75, pages 104293.
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Pranesh Kumar, Aakriti Agarwal, Ashok K. Singh, Anurag Kumar Gautam, Sreemoyee Chakraborti, Umesh Kumar, Dinesh Kumar, Bolay Bhattacharya, Parthasarathi Panda, Biswajit Saha, Tabish Qidwai, Biswanath Maity & Sudipta Saha. (2019) Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis. Regulatory Toxicology and Pharmacology 109, pages 104489.
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Vimal Maurya, Pranesh Kumar, Sreemoyee Chakraborti, Ashok K. Singh, Archana S. Bhadauria, Umesh Kumar, Dinesh Kumar, Arnab Pramanik, Biswajit Saha, Venkatesh Kumar R, Sunil Babu Gosipatala, Bolay Bhattachariya, Biswanath Maity & Sudipta Saha. (2019) Zolmitriptan attenuates hepatocellular carcinoma via activation of caspase mediated apoptosis. Chemico-Biological Interactions 308, pages 120-129.
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Vinit Raj, Archana S. Bhadauria, Ashok K. Singh, Umesh Kumar, Amit Rai, Amit K. Keshari, Pranesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Kausar M. Ansari, Jawahar L. Jat & Sudipta Saha. (2019) Novel 1,3,4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling. Cytokine 118, pages 144-159.
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Wei Wang, Xilin Liu, Juan Wu, Xia Kang, Qingyun Xie, Jun Sheng, Wei Xu, Da Liu & Wei Zheng. (2019) Plasma metabolite profiling reveals potential biomarkers of giant cell tumor of bone by using NMR-based metabolic profiles. Medicine 98:40, pages e17445.
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Amit Rai, Umesh Kumar, Vinit Raj, Ashok K Singh, Pranesh Kumar, Amit K Keshari, Dinesh Kumar, Biswanath Maity, Arnab De, Amalesh Samanta, Sneha Nath, Anand Prakash, Sunil Babu Gosipatala, Gyan Chand & Sudipta Saha. (2018) Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. Pharmacological Research 132, pages 188-203.
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Ashok K. Singh, Archana Singh Bhadauria, Umesh Kumar, Vinit Raj, Vimal Maurya, Dinesh Kumar, Biswanath Maity, Anand Prakash, Arnab De, Amalesh Samanta & Sudipta Saha. (2018) Novel fused oxazepino-indoles (FOIs) attenuate liver carcinogenesis via IL-6/JAK2/STAT3 signaling blockade as evidenced through data-based mathematical modeling. Life Sciences 201, pages 161-172.
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Ashok K. Singh, Archana S. Bhadauria, Umesh Kumar, Vinit Raj, Amit Rai, Pranesh Kumar, Amit K. Keshari, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash & Sudipta Saha. (2018) Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals. Scientific Reports 8:1.
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Priyanka Mishra, Vinit Raj, Archana S. Bhadauria, Ashok K Singh, Amit Rai, Pranesh Kumar, Amit K Keshari, Arnab De, Amalesh Samanta, Umesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Kausar M. Ansari & Sudipta Saha. (2018) 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates colon carcinogenesis via blockade of IL-6 mediated signals. Biomedicine & Pharmacotherapy 100, pages 282-295.
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