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Research Paper

The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis

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Pages 584-595 | Received 09 Jan 2017, Accepted 17 Jun 2017, Published online: 11 Aug 2017

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Ping Chen, Sungui Wu, Xiaoqing Dong, Min Zhou, Peipei Xu & Bing Chen. (2022) Formosanin C induces autophagy-mediated apoptosis in multiple myeloma cells through the PI3K/AKT/mTOR signaling pathway. Hematology 27:1, pages 977-986.
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Hamed Bashiri & Hossein Tabatabaeian. (2023) Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma. International Journal of Molecular Sciences 24:7, pages 6019.
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Kevser Taban Akça, İlknur Çınar Ayan, Sümeyra Çetinkaya, Ece Miser Salihoğlu & İpek Süntar. (2023) Autophagic mechanisms in longevity intervention: role of natural active compounds. Expert Reviews in Molecular Medicine 25.
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Jiali Ji, Ke Wang, Xinmin Meng, Hongqin Zhong, Xiyue Li, Hongqing Zhao, Guijuan Xie, Yunying Xie, Xun Wang & Xue Zhu. (2022) Elaiophylin Inhibits Tumorigenesis of Human Lung Adenocarcinoma by Inhibiting Mitophagy via Suppression of SIRT1/Nrf2 Signaling. Cancers 14:23, pages 5812.
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Rajeev K. Singla, Pooja Sharma, Dinesh Kumar, Rupesh K. Gautam, Rajat Goyal, Christos Tsagkaris, Ankit Kumar Dubey, Himangini Bansal, Rohit Sharma & Bairong Shen. (2022) The role of nanomaterials in enhancing natural product translational potential and modulating endoplasmic reticulum stress in the treatment of ovarian cancer. Frontiers in Pharmacology 13.
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Guan-Nan Li, Xue-Jiao Zhao, Zhen Wang, Meng-Shi Luo, Shen-Nan Shi, Dan-Mei Yan, Hua-Yi Li, Jia-Hao Liu, Yang Yang, Jia-Hong Tan, Ze-Yu Zhang, Ru-Qi Chen, Hui-Ling Lai, Xiao-Yuan Huang, Jian-Feng Zhou, Ding Ma, Yong Fang & Qing-Lei Gao. (2022) Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation. Signal Transduction and Targeted Therapy 7:1.
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Wen Zhang, Jingwen Liu, Yiming Li & Fujiang Guo. (2022) A bavachinin analog, D36, induces cell death by targeting both autophagy and apoptosis pathway in acute myeloid leukemia cells. Cancer Chemotherapy and Pharmacology 90:3, pages 251-265.
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Qiaoyan Han, Hua Bai, Yong Xu, Min Zhou, He Zhou, Xiaoqing Dong & Bing Chen. (2022) Solamargine induces autophagy‐mediated apoptosis and enhances bortezomib activity in multiple myeloma. Clinical and Experimental Pharmacology and Physiology 49:6, pages 674-685.
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Srimanta Patra, Soumya R. Mishra, Bishnu P. Behera, Kewal K. Mahapatra, Debasna P. Panigrahi, Chandra S. Bhol, Prakash P. Praharaj, Gautam Sethi, Samir K. Patra & Sujit K. Bhutia. (2022) Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives. Seminars in Cancer Biology 80, pages 205-217.
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Xue Zhu, Wenjun Zou, Xinmin Meng, Jiali Ji, Xun Wang, Hong Shu, Yuan Chen, Donghui Pan, Ke Wang & Fanfan Zhou. (2022) Elaiophylin Inhibits Tumorigenesis of Human Uveal Melanoma by Suppressing Mitophagy and Inducing Oxidative Stress via Modulating SIRT1/FoxO3a Signaling. Frontiers in Oncology 12.
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Yasuko Kohda, Shuichi Sakamoto, Maya Umekita, Tomoyuki Kimura, Yumiko Kubota, Rie Arisaka, Yuko Shibuya, Hideyuki Muramatsu, Ryuichi Sawa, Shingo Dan, Manabu Kawada & Masayuki Igarashi. (2021) Isolation of new derivatives of the 20-membered macrodiolide bispolide from Kitasatospora sp. MG372-hF19. The Journal of Antibiotics 75:2, pages 77-85.
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Garima Tripathi, Shambhavi Mishra, Ambarish Priyadarshan, Satya Narayan Sahu, Anil Kumar Singh & Abhijeet Kumar. 2022. Autophagy and Metabolism. Autophagy and Metabolism 215 238 .
Ruoxuan Bao, Yongmei Meng, Haibo Zhang, Chen Yang, Wei Li, Cheng Zhang, Jinye Zhang, Renqiang Sun, Zengxia Li, Wei Jiang, Chensong Zhang, Changsheng Zhang, Hai-Xin Yuan & Yongjun Dang. (2021) Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. Cell Death & Disease 12:11.
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Cristina Rodrigues dos Santos Barbosa, Débora Feitosa Muniz, Pedro Silvino Pereira, Sandrine Maria de Arruda Lima, Cícera Datiane de Morais Oliveira Tintino, Veruska Cintia Alexandrino de Souza, Julia Mariana Assis da Silva, Roger Henrique Sousa da Costa, Jacqueline Cosmo Andrade Pinheiro, Yedda Maria Lobo Soares de Matos, Irwin Rose Alencar Menezes, Teresinha Gonçalves da Silva, Gláucia Manoella de Souza Lima, Tereza Cristina Leal Balbino, José Pinto Siqueira-Júnior, Francisco Assis Bezerra da Cunha, Henrique Douglas Melo Coutinho & Saulo Relison Tintino. (2021) Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach. Bioorganic & Medicinal Chemistry Letters 50, pages 128334.
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Farid A. Siddiqui, Vladimir Vukic, Tiina A. Salminen & Daniel Abankwa. (2021) Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity. Biomolecules 11:6, pages 836.
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Dong Wook Shin. (2020) Dual Roles of Autophagy and Their Potential Drugs for Improving Cancer Therapeutics. Biomolecules & Therapeutics 28:6, pages 503-511.
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Maurizio Fazio, Julien Ablain, Yan Chuan, David M. Langenau & Leonard I. Zon. (2020) Zebrafish patient avatars in cancer biology and precision cancer therapy. Nature Reviews Cancer 20:5, pages 263-273.
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Guoping Dong, Zhe Zhang, Kun Duan, Wenpeng Shi, Rui Huang, Bangjun Wang, Lingfei Luo, Yaoguang Zhang, Hua Ruan & Honghui Huang. (2020) Beclin 1 deficiency causes hepatic cell apoptosis via endoplasmic reticulum stress in zebrafish larvae. FEBS Letters 594:7, pages 1155-1165.
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Jianjian Zhuang, Juxin Yin, Chaojian Xu, Mengmeng Jiang & Shaowu Lv. (2019) Diverse autophagy and apoptosis in myeloid leukemia cells induced by 20(s)-GRh2 and blue LED irradiation. RSC Advances 9:67, pages 39124-39132.
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Min Gui, Meng-xue Zhang, Wen-hui Wu & Peng Sun. (2019) Natural Occurrence, Bioactivity and Biosynthesis of Elaiophylin Analogues. Molecules 24:21, pages 3840.
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Puglisi, Parrinello, Giallongo, Cambria, Camiolo, Bellofiore, Conticello, Fabro, Leotta, Markovic, Sapienza, Barbato, Scalese, Tibullo, Brundo, Palumbo, * Romano. (2019) Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy via STAT3. International Journal of Molecular Sciences 20:14, pages 3548.
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Mojgan Djavaheri-Mergny, Sylvie Giuriato, Mario P. Tschan & Magali Humbert. (2019) Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma. Cells 8:2, pages 103.
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V. Desantis, I. Saltarella, A. Lamanuzzi, M.A. Mariggiò, V. Racanelli, Angelo Vacca & M.A. Frassanito. (2018) Autophagy: A New Mechanism of Prosurvival and Drug Resistance in Multiple Myeloma. Translational Oncology 11:6, pages 1350-1357.
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Kiana Hosseinpour‐Moghaddam, Michele Caraglia & Amirhossein Sahebkar. (2018) Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts. Journal of Cellular Physiology 233:9, pages 6524-6543.
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