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Cancer Biology & Therapy Volume 19, 2018 - Issue 1
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Research Papers

Identification of WEE1 as a target to make AKT inhibition more effective in melanoma

Omer F. KuzuThe Pennsylvania State University College of Medicine, Department of Pharmacology, Hershey, PAORCID Iconhttp://orcid.org/0000-0001-8715-4800
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Raghavendra GowdaThe Pennsylvania State University College of Medicine, Department of Pharmacology, Hershey, PA;The Pennsylvania State University College of Medicine, The Melanoma and Skin Cancer Center, Hershey, PA;The Melanoma Therapeutics Program, 500 University Drive, Hershey, PAORCID Iconhttp://orcid.org/0000-0003-2312-8384
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Arati SharmaThe Pennsylvania State University College of Medicine, Department of Pharmacology, Hershey, PAORCID Iconhttp://orcid.org/0000-0001-7178-949X
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Mohammad A. NooryThe Pennsylvania State University College of Medicine, Department of Pharmacology, Hershey, PAORCID Iconhttp://orcid.org/0000-0002-8376-0704
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Gregory KardosThe Pennsylvania State University College of Medicine, Department of Pharmacology, Hershey, PAORCID Iconhttp://orcid.org/0000-0001-9706-6652
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SubbaRao V. MadhunapantulaThe Pennsylvania State University College of Medicine, Department of Pharmacology, Hershey, PAORCID Iconhttp://orcid.org/0000-0001-9167-9271
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Joseph J. DrabickThe Pennsylvania State University College of Medicine, Department of Medicine, Division of Hematology-Oncology, Hershey, PA;The Pennsylvania State University College of Medicine, The Melanoma and Skin Cancer Center, Hershey, PA;The Melanoma Therapeutics Program, 500 University Drive, Hershey, PAORCID Iconhttp://orcid.org/0000-0002-7630-2721
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Gavin P. RobertsonThe Pennsylvania State University College of Medicine, Department of Pharmacology, Hershey, PA;The Pennsylvania State University College of Medicine, Department of Pathology, Hershey, PA;The Pennsylvania State University College of Medicine, Department of Dermatology, Hershey, PA;The Pennsylvania State University College of Medicine, Department of Surgery, Hershey, PA;The Pennsylvania State University College of Medicine, The Melanoma and Skin Cancer Center, Hershey, PA;The Melanoma Therapeutics Program, 500 University Drive, Hershey, PACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-0152-2997
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Pages 53-62 | Received 04 Mar 2017, Accepted 23 Aug 2017, Published online: 30 Nov 2017

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Yu Guo, Yizhen Jin, Bingxue Qu, Yu Zhang, Jinxin Che & Xiaowu Dong. (2021) An updated patent review of Akt inhibitors (2016-present). Expert Opinion on Therapeutic Patents 31:9, pages 837-849.
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Siqing Fu, Yudong Wang, Khandan Keyomarsi & Funda Meric-Bernstein. (2018) Strategic development of AZD1775, a Wee1 kinase inhibitor, for cancer therapy. Expert Opinion on Investigational Drugs 27:9, pages 741-751.
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Articles from other publishers (9)

Saketh S. Dinavahi, Yu-Chi Chen, Kishore Punnath, Arthur Berg, Meenhard Herlyn, Momeneh Foroutan, Nicholas D. Huntington & Gavin P. Robertson. (2022) Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma. Cancer Immunology Research 10:6, pages 757-769.
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Luisa Maresca, Barbara Stecca & Laura Carrassa. (2022) Novel Therapeutic Approaches with DNA Damage Response Inhibitors for Melanoma Treatment. Cells 11:9, pages 1466.
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Jie Jiang, Chong Liu, Guoyong Xu, Tuo Liang, Chaojie Yu, Shian Liao, Zide Zhang, Zhaojun Lu, Zequn Wang, Jiarui Chen, Tianyou Chen, Hao Li & Xinli Zhan. (2021) Identification of Hub Genes Associated With Melanoma Development by Comprehensive Bioinformatics Analysis. Frontiers in Oncology 11.
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Tzu-Ting Huang, Erika J. Lampert, Cynthia Coots & Jung-Min Lee. (2020) Targeting the PI3K pathway and DNA damage response as a therapeutic strategy in ovarian cancer. Cancer Treatment Reviews 86, pages 102021.
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Ishani Das, Margareta Wilhelm, Veronica Höiom, Rodolfo Franco Marquez, Fernanda Costa Svedman, Johan Hansson, Rainer Tuominen & Suzanne Egyhàzi Brage. (2019) Combining ERBB family and MET inhibitors is an effective therapeutic strategy in cutaneous malignant melanoma independent of BRAF/NRAS mutation status. Cell Death & Disease 10:9.
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Paola M. Dantonio, Marianne O. Klein, Maria Renata V.B. Freire, Camila N. Araujo, Ana Carolina Chiacetti & Ricardo G. Correa. (2018) Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy. Bioscience Reports 38:5.
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Saketh S. Dinavahi, Mohammad A. Noory, Raghavendra Gowda, Joseph J. Drabick, Arthur Berg, Rogerio I. Neves & Gavin P. Robertson. (2018) Moving Synergistically Acting Drug Combinations to the Clinic by Comparing Sequential versus Simultaneous Drug Administrations. Molecular Pharmacology 93:3, pages 190-196.
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Qingnan Liu, Xiaotian Qu, Xiaolei Xie, Pei He & Shi Huang. (2018) Repression of Akt3 gene transcription by the tumor suppressor RIZ1. Scientific Reports 8:1.
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Guan-Jun Yang, Hai-Jing Zhong, Chung-Nga Ko, Suk-Yu Wong, Kasipandi Vellaisamy, Min Ye, Dik-Lung Ma & Chung-Hang Leung. (2018) Identification of a rhodium( iii ) complex as a Wee1 inhibitor against TP53 -mutated triple-negative breast cancer cells . Chemical Communications 54:20, pages 2463-2466.
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