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Cancer Biology & Therapy Volume 20, 2019 - Issue 5
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Research Paper

Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gαq and Gα11 and kill uveal melanoma cells

Laurence BoothDepartments of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USAView further author information
,
Jane L. RobertsDepartments of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USAView further author information
,
Cindy SanderMelanoma and Skin Cancer Program, Hillman Cancer Research Pavilion Laboratory, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USAORCID Iconhttp://orcid.org/0000-0002-4136-1342View further author information
ORCID Icon,
Alshad S. LalaniPuma Biotechnology Inc., Los Angeles, CA, USAView further author information
,
John M. KirkwoodMelanoma and Skin Cancer Program, Hillman Cancer Research Pavilion Laboratory, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USAView further author information
,
John F. HancockDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, TX, USAView further author information
,
Andrew PoklepovicDepartments of Medicine, Virginia Commonwealth University, Richmond, VA, USAView further author information
&
Paul DentDepartments of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USACorrespondence[email protected]
View further author information
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Pages 700-710 | Received 13 Nov 2018, Accepted 15 Nov 2018, Published online: 20 Dec 2018

Citations (31)

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Yi Fan Li, Li Dong, Yang Li & Wen Bin Wei. (2020) A Review of MicroRNA in Uveal Melanoma. OncoTargets and Therapy 13, pages 6351-6359.
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Articles from other publishers (30)

Tarapong Srisongkram & Natthida Weerapreeyakul. (2022) Drug Repurposing against KRAS Mutant G12C: A Machine Learning, Molecular Docking, and Molecular Dynamics Study. International Journal of Molecular Sciences 24:1, pages 669.
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Yiqun Zhang, Shijie Lan & Di Wu. (2022) Advanced Acral Melanoma Therapies: Current Status and Future Directions. Current Treatment Options in Oncology 23:10, pages 1405-1427.
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Paul Dent, Laurence Booth, Andrew Poklepovic & John F. Hancock. (2022) Neratinib as a Potential Therapeutic for Mutant RAS and Osimertinib-Resistant Tumours. European Medical Journal, pages 127-133.
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Wenying Shu, Xue Zhu, Ke Wang, Svetlana Cherepanoff, R. Max Conway, Michele C. Madigan, Hong Zhu, Ling Zhu, Michael Murray & Fanfan Zhou. (2022) The multi-kinase inhibitor afatinib serves as a novel candidate for the treatment of human uveal melanoma. Cellular Oncology 45:4, pages 601-619.
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Peiwei Chai, Ruobing Jia, Yongyun Li, Chuandi Zhou, Xiang Gu, Ludi Yang, Hanhan Shi, Hao Tian, Huimin Lin, Jie Yu, Ai Zhuang, Shengfang Ge, Renbing Jia & Xianqun Fan. (2022) Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma. Progress in Retinal and Eye Research 89, pages 101030.
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Yihang Fu, Wei Xiao & Yuxiang Mao. (2022) Recent Advances and Challenges in Uveal Melanoma Immunotherapy. Cancers 14:13, pages 3094.
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Stanley Zhang, Ke Wang, Xue Zhu, Svetlana Cherepanoff, R. Max Conway, Michele C. Madigan, Ling Zhu, Michael Murray & Fanfan Zhou. (2022) The unfolded protein response and the biology of uveal melanoma. Biochimie 197, pages 9-18.
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Manel Benhassine, Gaëtan Le-Bel & Sylvain L. Guérin. (2022) Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal Melanoma. International Journal of Molecular Sciences 23:3, pages 1564.
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Paul Dent, Laurence Booth, Andrew Poklepovic & John M. Kirkwood. (2021) Neratinib kills B‐RAF V600E melanoma via ROS‐dependent autophagosome formation and death receptor signaling. Pigment Cell & Melanoma Research 35:1, pages 66-77.
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Elisabetta Catalani, Matteo Giovarelli, Silvia Zecchini, Cristiana Perrotta & Davide Cervia. (2021) Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate. Cancers 13:22, pages 5791.
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Rino S. Seedor, Marlana Orloff & Takami Sato. (2021) Genetic Landscape and Emerging Therapies in Uveal Melanoma. Cancers 13:21, pages 5503.
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Ruchi P. Patel, Joanna R. Thomas, Katherine M. Curt, Christina M. Fitzsimmons, Pedro J. Batista, Susan E. Bates, Michael M. Gottesman & Robert W. Robey. (2021) Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma. Investigative Opthalmology & Visual Science 62:12, pages 16.
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Christophe Glorieux, Xiaojun Xia & Peng Huang. (2021) The Role of Oncogenes and Redox Signaling in the Regulation of PD-L1 in Cancer. Cancers 13:17, pages 4426.
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Paul Dent, Andrew Poklepovic, Laurence Booth & John F. Hancock. (2021) The development of multi-kinase inhibitors as pancreatic cancer therapeutics. Anti-Cancer Drugs 32:8, pages 779-785.
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Caterina Bartolacci, Cristina Andreani, Yasmin El-Gammal & Pier Paolo Scaglioni. (2021) Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy. Frontiers in Molecular Biosciences 8.
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Paul Dent, Laurence Booth, Andrew Poklepovic, Daniel Von Hoff, Jennifer Martinez, Yong Zhou & John F. Hancock. (2021) Osimertinib-resistant NSCLC cells activate ERBB2 and YAP/TAZ and are killed by neratinib. Biochemical Pharmacology 190, pages 114642.
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Paul Dent, Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Derek Cridebring & Eric M. Reiman. (2021) Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43. Aging 13:13, pages 17097-17117.
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Laurence A. Booth, Jane L. Roberts & Paul Dent. (2020) The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib. Seminars in Cancer Biology 66, pages 129-139.
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Laurence Booth, Jane L. Roberts, Cameron West, Daniel Von Hoff & Paul Dent. (2020) GZ17‐6.02 initiates DNA damage causing autophagosome‐dependent HDAC degradation resulting in enhanced anti‐PD1 checkpoint inhibitory antibody efficacy. Journal of Cellular Physiology 235:11, pages 8098-8113.
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Paul Dent, Laurence Booth, Andrew Poklepovic, Jennifer Martinez, Daniel Von Hoff & John F. Hancock. (2020) Neratinib degrades MST4 via autophagy that reduces membrane stiffness and is essential for the inactivation of PI3K, ERK1/2, and YAP/TAZ signaling. Journal of Cellular Physiology 235:11, pages 7889-7899.
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Paul Dent, Laurence Booth, Jane L. Roberts, Andrew Poklepovic & John F. Hancock. (2020) (Curcumin+sildenafil) enhances the efficacy of 5FU and anti‐PD1 therapies in vivo. Journal of Cellular Physiology 235:10, pages 6862-6874.
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John M. Idso, Shunhua Lao, Nathan J. Schloemer, Jeffrey Knipstein, Robert Burns, Monica S. Thakar & Subramaniam Malarkannan. (2020) Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway. Oncotarget 11:20, pages 1799-1815.
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Yongyun Li, Jiahao Shi, Jie Yang, Shengfang Ge, Jianming Zhang, Renbing Jia & Xianqun Fan. (2020) Uveal melanoma: progress in molecular biology and therapeutics. Therapeutic Advances in Medical Oncology 12, pages 175883592096585.
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Paul Peixoto, Céline Grandvallet, Jean-Paul Feugeas, Michaël Guittaut & Eric Hervouet. (2019) Epigenetic Control of Autophagy in Cancer Cells: A Key Process for Cancer-Related Phenotypes. Cells 8:12, pages 1656.
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Paul Dent, Laurence Booth, Andrew Poklepovic & John F. Hancock. (2019) Signaling alterations caused by drugs and autophagy. Cellular Signalling 64, pages 109416.
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Paul Dent, Andrew Poklepovic & Laurence Booth. (2019) Discovery of a ‘Grail-Shaped’ Drug: Ne-ratinib and the Downregulation of Mutant RAS. EMJ Oncology, pages 81-89.
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Laurence Booth, Jane L. Roberts, Andrew Poklepovic & Paul Dent. (2019) The Lethality of [Pazopanib + HDAC Inhibitors] Is Enhanced by Neratinib. Frontiers in Oncology 9.
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Paul Dent, Laurence Booth, Jane L. Roberts, Junchen Liu, Andrew Poklepovic, Alshad S. Lalani, David Tuveson, Jennifer Martinez & John F. Hancock. (2019) Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells. Oncogene 38:30, pages 5890-5904.
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Croce, Ferrini, Pfeffer & Gangemi. (2019) Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives. Cancers 11:6, pages 846.
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. (2019) Metabolism of Histone Deacetylase Proteins Opsonizes Tumor Cells to Checkpoint Inhibitory Immunotherapies. Immunometabolism.
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