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Cancer Biology & Therapy Volume 21, 2020 - Issue 1
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Research Paper

Identification of anti-CD16a single domain antibodies and their application in bispecific antibodies

Yining ZhaoSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China;Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
,
Yumei LiSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China;Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
,
Xiaoqiong WuSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China;Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
,
Li LiSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China;Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
,
Jiayu LiuSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China;Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
,
Yanlan WangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China;Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
,
Yue LiuSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China;Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
,
Qing LiSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China;Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, ChinaCorrespondence[email protected]
&
Zhong WangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China;Center for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, ChinaCorrespondence[email protected]
 show all
Pages 72-80 | Received 24 Jan 2019, Accepted 01 Sep 2019, Published online: 29 Sep 2019

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Karolina Pierzynowska, Joanna Morcinek-Orłowska, Lidia Gaffke, Weronika Jaroszewicz, Piotr M. Skowron & Grzegorz Węgrzyn. (2023) Applications of the phage display technology in molecular biology, biotechnology and medicine. Critical Reviews in Microbiology 0:0, pages 1-41.
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Min-ling Liu, Zi-jian Chen, Xiao-qing Huang, Hong Wang, Jin-li Zhao, Yu-dong Shen, Lin Luo, Xiao-wei Wen, Bruce Hammock & Zhen-lin Xu. (2023) A bispecific nanobody with high sensitivity/efficiency for simultaneous determination of carbaryl and its metabolite 1-naphthol in the soil and rice samples. Environmental Pollution 335, pages 122265.
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Yangyang Li, Siqi Xie, Minhua Chen, Hao Li, Yehai Wang, Yan Fan, Kang An, Yu Wu & Weihua Xiao. (2023) Development of an antibody-ligand fusion protein scFvCD16A-sc4-1BBL in Komagataella phaffii with stimulatory activity for Natural Killer cells. Microbial Cell Factories 22:1.
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Amirhosein Maali, Monireh Gholizadeh, Saba Feghhi-Najafabadi, Ahmad Noei, Seyedeh Sheila Seyed-Motahari, Shafieeh Mansoori & Zahra Sharifzadeh. (2023) Nanobodies in cell-mediated immunotherapy: On the road to fight cancer. Frontiers in Immunology 14.
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Yumei Li, Lingjun Wu, Yueying Liu, Siwen Ma, Biyi Huang, Xianjing Feng & Hui Wang. (2022) A novel multifunctional anti-PD-L1-CD16a-IL15 induces potent cancer cell killing in PD-L1-positive tumour cells. Translational Oncology 21, pages 101424.
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Mehdi Arbabi-Ghahroudi. (2022) Camelid Single-Domain Antibodies: Promises and Challenges as Lifesaving Treatments. International Journal of Molecular Sciences 23:9, pages 5009.
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Yueyuan Yin, Fei Yan, Ruimin Zhou, Mingchen Li, Jinyi Ma, Zhe Liu & Zhenyi Ma. (2021) Single-domain antibody screening by is PLA-seq . Life Science Alliance 5:1, pages e202101115.
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Elizabeth A. Lampros, Paul G. Kremer, Jesús S. Aguilar Díaz de León, Elijah T. Roberts, Maria Carolina Rodriguez Benavente, I. Jonathan Amster & Adam W. Barb. (2022) The antibody-binding Fc gamma receptor IIIa / CD16a is N-glycosylated with high occupancy at all five sites. Current Research in Immunology 3, pages 128-135.
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Yumei Li, Yanwen Zhu, Shu Feng, Yuji Ishida, Tsu-Pei Chiu, Takeshi Saito, Sean Wang, David K. Ann & Jing-hsiung James Ou. (2022) Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3. Cell Reports 38:4, pages 110284.
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Ondřej Vaněk, Barbora Kalousková, Celeste Abreu, Shiva Nejadebrahim & Ondřej Skořepa. 2022. Immunotherapeutics. Immunotherapeutics 91 133 .
Henk van Faassen, Dong-Hyeon Jo, Shannon Ryan, Michael J. Lowden, Shalini Raphael, C. Roger MacKenzie, Seung-Hwan Lee, Greg Hussack & Kevin A. Henry. (2021) Incorporation of a Novel CD16-Specific Single-Domain Antibody into Multispecific Natural Killer Cell Engagers With Potent ADCC. Molecular Pharmaceutics 18:6, pages 2375-2384.
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Zhimin Xu, Chuangnan Qiu, Biyan Wen, Shuang Wang, Linfeng Zhu, Lin Zhao & Huangjin Li. (2021) A bispecific nanobody targeting the dimerization interface of epidermal growth factor receptor: Evidence for tumor suppressive actions in vitro and in vivo. Biochemical and Biophysical Research Communications 548, pages 78-83.
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Anthony Brouillard, Nilesh Deshpande & Ashish A. Kulkarni. (2021) Engineered Multifunctional Nano‐ and Biological Materials for Cancer Immunotherapy. Advanced Healthcare Materials 10:6.
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Zi-Wen Han, Zhi-Wu Lyv, Bin Cui, Ying-Ying Wang, Jun-Ting Cheng, Ying Zhang, Wen-Qi Cai, Yang Zhou, Zhao-Wu Ma, Xian-Wang Wang, Xiao-Chun Peng, Shu-Zhong Cui, Ying Xiang, Mo Yang & Hong-Wu Xin. (2020) The old CEACAMs find their new role in tumor immunotherapy. Investigational New Drugs 38:6, pages 1888-1898.
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Ario de Marco. (2020) Recombinant expression of nanobodies and nanobody-derived immunoreagents. Protein Expression and Purification 172, pages 105645.
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Emily Y. Yang & Khalid Shah. (2020) Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics. Frontiers in Oncology 10.
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