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Cancer Biology & Therapy Volume 21, 2020 - Issue 5
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Research Paper

Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases

Vegar Johansen DagenborgDepartment of Tumor Biology, Oslo University Hospital, Oslo, Norway;Institute of Clinical Medicine, University of Oslo, Oslo, Norway;Department of Gastroenterological Surgery, Oslo University Hospital, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0002-9851-1866View further author information
ORCID Icon,
Serena Elizabeth MarshallDepartment of Tumor Biology, Oslo University Hospital, Oslo, Norway;Institute of Clinical Medicine, University of Oslo, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0002-0943-1291View further author information
ORCID Icon,
Sheraz YaqubDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0002-5696-2319View further author information
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Krzysztof GrzybDepartment of Pathology, Oslo University Hospital, Oslo, NorwayView further author information
,
Kjetil BoyeDepartment of Tumor Biology, Oslo University Hospital, Oslo, Norway;Department Department of Oncology, Oslo University Hospital, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0002-5552-6283View further author information
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Marius Lund-IversenDepartment of Pathology, Oslo University Hospital, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0002-2025-4062View further author information
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Eirik HøyeDepartment of Tumor Biology, Oslo University Hospital, Oslo, NorwayView further author information
,
Audun E BerstadDepartment of Radiology, Oslo University Hospital, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0002-5862-3329View further author information
ORCID Icon,
Åsmund Avdem FretlandDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway;The Intervention Center, Oslo University Hospital, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0002-0945-5189View further author information
ORCID Icon,
Bjørn EdwinInstitute of Clinical Medicine, University of Oslo, Oslo, Norway;Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway;The Intervention Center, Oslo University Hospital, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0002-3137-6225View further author information
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Anne Hansen ReeInstitute of Clinical Medicine, University of Oslo, Oslo, Norway;Department of Oncology, Akershus University Hospital, Lørenskog, NorwayORCID Iconhttps://orcid.org/0000-0002-8264-3223View further author information
ORCID Icon &
Kjersti FlatmarkDepartment of Tumor Biology, Oslo University Hospital, Oslo, Norway;Institute of Clinical Medicine, University of Oslo, Oslo, Norway;Department of Gastroenterological Surgery, Oslo University Hospital, Oslo, NorwayCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7409-0780View further author information
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Pages 432-440 | Received 17 Jun 2019, Accepted 17 Jan 2020, Published online: 26 Feb 2020

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Amy Body, Hans Prenen, Sarah Latham, Marissa Lam, Samuel Tipping-Smith, Ajay Raghunath & Eva Segelov. (2021) The Role of Neoadjuvant Chemotherapy in Locally Advanced Colon Cancer. Cancer Management and Research 13, pages 2567-2579.
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Articles from other publishers (17)

Yong Xi, Lijie Chen, Jian Tang, Bentong Yu, Weiyu Shen & Xing Niu. (2023) Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy. Immunological Reviews.
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Zhen Liu, Yongjin LuoLinhong SuXiaoxia Hu. (2023) Identification of immunogenic cell death-related subtypes used for predicting survival and immunotherapy of endometrial carcinoma through a bioinformatics analysis. Medicine 102:31, pages e34571.
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Fukang Shi, Xing Huang, Zhengtao Hong, Na Lu, Xin Huang, Lingyue Liu, Tingbo Liang & Xueli Bai. (2023) Improvement strategy for immune checkpoint blockade: A focus on the combination with immunogenic cell death inducers. Cancer Letters 562, pages 216167.
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Eirik Høye, Vegar J Dagenborg, Annette Torgunrud, Christin Lund-Andersen, Åsmund A Fretland, Susanne Lorenz, Bjørn Edwin, Eivind Hovig, Bastian Fromm, Else M Inderberg, Victor Greiff, Anne H Ree & Kjersti Flatmark. (2023) T cell receptor repertoire sequencing reveals chemotherapy-driven clonal expansion in colorectal liver metastases. GigaScience 12.
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Sebastian Meltzer, Anne Negård, Kine M. Bakke, Hanne M. Hamre, Christian Kersten, Eva Hofsli, Marianne G. Guren, Halfdan Sorbye, Kjersti Flatmark & Anne Hansen Ree. (2022) Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer. British Journal of Cancer 127:12, pages 2227-2233.
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Phoenix D Bell & Reetesh K Pai. (2022) Immune response in colorectal carcinoma: a review of its significance as a predictive and prognostic biomarker. Histopathology 81:6, pages 696-714.
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Kellsye P. Fabian, Joshua T. Kowalczyk, Sandy T. Reynolds & James W. Hodge. (2022) Dying of Stress: Chemotherapy, Radiotherapy, and Small-Molecule Inhibitors in Immunogenic Cell Death and Immunogenic Modulation. Cells 11:23, pages 3826.
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Yujie Wang, Peng Gao, Zhibin Hao, Ling Chen, Xiaoxiao Li, Yuan Jiao, Jingyu Liu, Jie Li, Yingyi Zhang, Xiaobo Peng, Beifang Ning & Xianbao Zhan. (2022) The effect of neoadjuvant chemotherapy on the tumor immune microenvironment in gastrointestinal tumors. Frontiers in Oncology 12.
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Yangsong He, Yanan Han, A-hui Fan, Danxiu Li, Boda Wang, Kun Ji, Xin Wang, Xiaodi Zhao & Yuanyuan Lu. (2022) Multi-perspective comparison of the immune microenvironment of primary colorectal cancer and liver metastases. Journal of Translational Medicine 20:1.
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Ashish Manne & Anne Noonan. 2022. Contemporary Management of Metastatic Colorectal Cancer. Contemporary Management of Metastatic Colorectal Cancer 231 246 .
Kellsye P. Fabian, Benjamin Wolfson & James W. Hodge. (2021) From Immunogenic Cell Death to Immunogenic Modulation: Select Chemotherapy Regimens Induce a Spectrum of Immune-Enhancing Activities in the Tumor Microenvironment. Frontiers in Oncology 11.
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Vegar Johansen Dagenborg, Serena Elizabeth Marshall, Krzysztof Grzyb, Åsmund Avdem Fretland, Marius Lund-Iversen, Gunhild Mari Mælandsmo, Anne Hansen Ree, Bjørn Edwin, Sheraz Yaqub & Kjersti Flatmark. (2021) Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer. Frontiers in Oncology 11.
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Yongjiu Dai, Wenhu Zhao, Lei Yue, Xinzheng Dai, Dawei Rong, Fan Wu, Jian Gu & Xiaofeng Qian. (2021) Perspectives on Immunotherapy of Metastatic Colorectal Cancer. Frontiers in Oncology 11.
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Karianne Giller Fleten, J. Johannes Eksteen, Brynjar Mauseth, Ketil André Camilio, Terje Vasskog, Baldur Sveinbjørnsson, Øystein Rekdal, Gunhild M. Mælandsmo & Kjersti Flatmark. (2021) Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer. Scientific Reports 11:1.
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Alessandra Rigamonti, Friedrich Feuerhake, Matteo Donadon, Massimo Locati & Federica Marchesi. (2021) Histopathological and Immune Prognostic Factors in Colo-Rectal Liver Metastases. Cancers 13:5, pages 1075.
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Parul Agarwal, Dung T. Le & Patrick M. Boland. 2021. Novel Approaches to Colorectal Cancer. Novel Approaches to Colorectal Cancer 137 196 .

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