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Cancer Biology & Therapy Volume 21, 2020 - Issue 5
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Research Paper

APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis

Erik S. BlomainDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USACorrespondence[email protected]
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Jeffrey A. RappaportDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USAView further author information
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Amanda M. PattisonDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USAView further author information
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Babar BashirDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USAORCID Iconhttps://orcid.org/0000-0002-6843-1179View further author information
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Ellen CaparosaDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USAView further author information
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Jonathan StemDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USAView further author information
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Adam E. SnookDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USAORCID Iconhttps://orcid.org/0000-0001-9216-4560View further author information
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Scott A. WaldmanDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USACorrespondence[email protected]
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Pages 441-451 | Received 29 Jul 2019, Accepted 20 Jan 2020, Published online: 09 Feb 2020

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Ariana A. Entezari, Adam E. Snook & Scott A. Waldman. (2021) Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential. Expert Opinion on Therapeutic Targets 25:5, pages 335-346.
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Amanda N. Lisby, John C. Flickinger$suffix/text()$suffix/text(), Babar Bashir, Megan Weindorfer, Sanjna Shelukar, Madison Crutcher, Adam E. Snook & Scott A. Waldman. (2021) GUCY2C as a biomarker to target precision therapies for patients with colorectal cancer. Expert Review of Precision Medicine and Drug Development 6:2, pages 117-129.
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Jeffrey A. Rappaport & Scott A. Waldman. (2020) An update on guanylyl cyclase C in the diagnosis, chemoprevention, and treatment of colorectal cancer. Expert Review of Clinical Pharmacology 13:10, pages 1125-1137.
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Amanda M. Pattison, Joshua R. Barton, Ariana A. Entezari, Alicja Zalewski, Jeff A. Rappaport, Adam E. Snook & Scott A. Waldman. (2020) Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity. Cancer Biology & Therapy 21:9, pages 799-805.
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Articles from other publishers (5)

Moein Piroozkhah, Ali Aghajani, Pooya Jalali, Arvin Shahmoradi, Mobin Piroozkhah, Younes Tadlili & Zahra Salehi. (2023) Guanylate cyclase-C Signaling Axis as a theragnostic target in colorectal cancer: a systematic review of literature. Frontiers in Oncology 13.
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Matthew D. Di Guglielmo, Jennifer Holbrook, Deborah Stabley, Katherine M. Robbins, Bobbie Boyce, Heather Hardy & Adebowale Adeyemi. (2023) The Intestinal Tract Brush Border in Young Children Uniformly Expresses Guanylate Cyclase C. Applied Immunohistochemistry & Molecular Morphology 31:3, pages 154-162.
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Adi Caspi, Ariana A Entezari, Madison Crutcher, Adam E Snook & Scott A Waldman. (2022) Guanylyl cyclase C as a diagnostic and therapeutic target in colorectal cancer. Personalized Medicine 19:5, pages 457-472.
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Jeffrey A. Rappaport, Ariana A. Entezari, Adi Caspi, Signe Caksa, Aakash V. Jhaveri, Timothy J. Stanek, Adam Ertel, Joan Kupper, Paolo M. Fortina, Steven B. McMahon, James B. Jaynes, Adam E. Snook & Scott A. Waldman. (2022) A β-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. Cellular and Molecular Gastroenterology and Hepatology 13:4, pages 1276-1296.
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John C FlickingerJrJr, Jeffrey A Rappaport, Joshua R Barton, Trevor R Baybutt, Amanda M Pattison, Adam E Snook & Scott A Waldman. (2021) Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies. Biomarkers in Medicine.
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