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Cancer Biology & Therapy Volume 22, 2021 - Issue 10-12
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Ibrutinib’s off-target mechanism: cause for dose optimization

Sara M. ZimmermanClinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAORCID Iconhttps://orcid.org/0000-0002-9007-8455View further author information
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Cody J. PeerClinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAView further author information
&
William D. FiggClinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USACorrespondence[email protected]
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Pages 529-531 | Received 14 Apr 2021, Accepted 24 Aug 2021, Published online: 10 Oct 2021

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Dan Jiang, Zaiwei Song, Yang Hu, Fei Dong & Rongsheng Zhao. (2022) Risk of bleeding associated with BTK inhibitor monotherapy: a systematic review and meta-analysis of randomized controlled trials. Expert Review of Clinical Pharmacology 15:8, pages 987-996.
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Articles from other publishers (6)

Hyun-ju Lee & Hyang-Sook Hoe. (2023) Repurposing ibrutinib: therapeutic effects and implications for translational approaches in Alzheimer’s disease. Neural Regeneration Research 18:10, pages 2194.
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Huanan Rao, Xiaominting Song, Jieting Lei, Peng Lu, Guiying Zhao, Xin Kang, Duanna Zhang, Tingrui Zhang, Yali Ren, Cheng Peng, Yuzhi Li, Jin Pei & Zhixing Cao. (2022) Ibrutinib Prevents Acute Lung Injury via Multi-Targeting BTK, FLT3 and EGFR in Mice. International Journal of Molecular Sciences 23:21, pages 13478.
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Tingyu Cao, Zengguang Wang & Xiaodong Zhu. (2022) The Immunomodulatory Functions of BTK Inhibition in the Central Nervous System. Journal of Inflammation Research Volume 15, pages 6427-6438.
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Aqu Alu, Hong Lei, Xuejiao Han, Yuquan Wei & Xiawei Wei. (2022) BTK inhibitors in the treatment of hematological malignancies and inflammatory diseases: mechanisms and clinical studies. Journal of Hematology & Oncology 15:1.
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Gellért Balázs Karvaly, István Vincze, Alexandra Balogh, Zoltán Köllő, Csaba Bödör & Barna Vásárhelyi. (2022) A High-Throughput Clinical Laboratory Methodology for the Therapeutic Monitoring of Ibrutinib and Dihydrodiol Ibrutinib. Molecules 27:15, pages 4766.
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Fansheng Ran, Yun Liu, Chen Wang, Zhongyuan Xu, Yanan Zhang, Yang Liu, Guisen Zhao & Yong Ling. (2022) Review of the development of BTK inhibitors in overcoming the clinical limitations of ibrutinib. European Journal of Medicinal Chemistry 229, pages 114009.
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